Resistência do Mycobacterium tuberculosis às drogas em pacientes HIV+ em cinco municípios da Baixada Santista, São Paulo, Brasil

Rozman, Luciana Martins; Santo, Augusto Hasiak; Rozman, Mauro Abrahão

doi:10.1590/s0102-311x2007000500007

Cited by 14 publications

(15 citation statements)

References 29 publications

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“…Such a finding deserves comment. The prevalence of TB-HIV co-infection in MDR-TB cases in our study was higher than that reported in other studies conducted in SP (Melo et al 2003, Telles et al 2005), but was similar to that found in another study in the metropolitan area of Santos (Rozman et al 2007). These inconsistencies may be explained by the fact that Santos is a port city and has one of the highest rates of HIV/AIDS in SP (SES 2010).…”

Section: Discussionsupporting

confidence: 85%

A study of multidrug-resistant tuberculosis in risk groups in the city of Santos, São Paulo, Brazil

Coelho

Zamarioli

Telles

et al. 2012

Mem. Inst. Oswaldo Cruz

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Monitoring the extent of and trends in multidrug-resistant tuberculosis (MDR-TB) is a priority of the Brazilian National Tuberculosis Control Programme. The current study aimed to estimate the incidence of MDR-TB, describe the profile of TB drug resistance in risk groups and examine whether screening for MDR-TB adhered to the recommended guidelines. A descriptive study that examined diagnosed cases of pulmonary TB was conducted in the city of Santos, Brazil, between 2000–2004. Of the 2,176 pulmonary TB cases studied, 671 (30.8%) met the criteria for drug sensitivity testing and, of these cases, 31.7% (213/671) were tested. Among the tested cases, 9.4% were resistant to one anti-TB drug and 15% were MDR. MDR was observed in 11.6% of 86 new TB cases and 17.3% of 127 previously treated cases. The average annual incidence of MDR-TB was 1.9 per 100,000 inhabitants-years. The extent of known MDR-TB in the city of Santos is high, though likely to be underestimated. Our study therefore indicates an inadequate adherence to the guidelines for MDR-TB screening and suggests the necessity of alternative strategies of MDR-TB surveillance.

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Section: Discussionsupporting

confidence: 85%

A study of multidrug-resistant tuberculosis in risk groups in the city of Santos, São Paulo, Brazil

Coelho

Zamarioli

Telles

et al. 2012

Mem. Inst. Oswaldo Cruz

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“…Considering the magnitude of TB as a public health issue, the economic importance of the city of Santos and the few published studies addressing this issue, (5) we aimed to describe the behavior of pulmonary TB (PTB) in the city of Santos, based on data obtained from the TB surveillance database. The principal objectives of the present study were to estimate incidence rates, mortality rates, retreatment rates and hospitalization rates, as well as the principal treatment outcomes (treatment abandonment, cure and death).…”

Section: Introductionmentioning

confidence: 99%

Características da tuberculose pulmonar em área hiperendêmica: município de Santos (SP)

et al. 2009

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Objective: To characterize the profile of patients with pulmonary tuberculosis (PTB) in the city of Santos, Brazil, according to biological, environmental and institutional factors. Methods: Descriptive study, using the TB surveillance database, including patients with PTB, aged 15 years or older, residing in the city of Santos and whose treatment was initiated between 2000 and 2004. Results: We identified 2,176 cases, of which 481 presented a history of TB. Of those 481 patients, 29.3% were cured, and 70.7% abandoned treatment. In 61.6% of the cases, the diagnosis was confirmed by sputum smear microscopy, whereas it was confirmed based on clinical and radiological criteria in 33.8%; 69.0% were male; and 69.5% were between 20 and 49 years of age. There were 732 hospitalizations, and the mean length of hospital stay was 32 days (first hospitalization). The prevalence of alcoholism, diabetes and TB/HIV coinfection was, respectively, 11.7%, 8.2% and 16.2%. The prevalence of TB/HIV coinfection decreased from 20.7% to 12.9% during the study period. The treatment outcome was cure, abandonment, death from TB and death attributed to TB/HIV coinfection in 71.0%, 12.1%, 3.9% and 2.5%, respectively. The directly observed treatment, short-course (DOTS) was adopted in 63.4% of cases, and there were no significant differences between DOTS and the conventional treatment approach in terms of outcomes (p > 0.05). The mean annual incidence of PTB was 127.9/100,000 population (range: 72.8-272.92/100,000 population, varying by region). The mean annual mortality rate for PTB was 6.9/100,000 population. Conclusions: In areas hyperendemic for TB, DOTS should be prioritized for groups at greater risk of treatment abandonment or death, and the investigation of TB contacts should be intensified.Keywords: Tuberculosis, pulmonary; Epidemiology, descriptive; Control. ResumoObjetivo: Caracterizar o perfil dos pacientes com tuberculose pulmonar (TBP) no município de Santos (SP) segundo fatores biológicos, ambientais e institucionais. Métodos: Estudo descritivo, com dados obtidos na vigilância da TB, abrangendo pacientes com TBP maiores de 15 anos de idade, residentes em Santos (SP) e com tratamento iniciado entre 2000 e 2004. Resultados: Foram identificados 2.176 casos, e 481 apresentavam história prévia de TB. Desses, 29,3% curaram-se no episódio anterior, e 70,7% abandonaram o tratamento. Em 61,6% e em 33,8% dos casos, o diagnóstico foi confirmado por baciloscopia e por critérios clínico-radiológicos, respectivamente; 69.0% eram homens, e 69,5% situavam-se entre 20 a 49 anos. Houve 732 hospitalizações, com tempo médio de permanência de 32 dias na primeira internação. A prevalência de alcoolismo, diabetes e coinfecção TB/HIV foi de, respectivamente, 11,7%, 8,2% e 16,2%, com declínio dessa última de 20,7% para 12,9% no período de estudo. O desfecho do tratamento para 71,0%, 12,1%, 3,2% e 3,3% foi, respectivamente, cura, abandono, óbito por TB e óbito por TB/HIV. O tratamento supervisionado de curta duração foi aplicado em 63,4% dos ca...

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“…2007; Davoudi et al. 2008), CD4 + lymphocyte cell counts do not always correlate with the chance of developing tuberculosis, as observed for other infectious diseases (Rozman et al. 2007).…”

Section: Discussionmentioning

confidence: 79%

“…This points to the need of establishing measures of local hospital mycobacteria surveillance, because HB as the regional reference centre for HIV/AIDS diagnosis and treatment deals with a great number of potentially TB‐co‐infected patients. Although tuberculosis is the most common opportunistic infection in HIV‐seropositive persons and CD4 + T lymphocytes are most important in the protective response against M. tuberculosis (Rozman et al. 2007; Davoudi et al.…”

Section: Discussionmentioning

confidence: 99%

Mycobacterium tuberculosis in a HIV‐1‐infected population from Southeastern Brazil in the HAART era

Pedro

Pereira

Goloni

et al. 2010

Tropical Med Int Health

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Summary Objective To evaluate retrospectively the microbiological profile of Mycobacterium species isolated from HIV‐infected patients attending the HIV/TB reference health care units in São José do Rio Preto, Brazil. Method Retrospective evaluation of all HIV‐1 positive patients whose IAL‐SJRP laboratorial analysis was positive for Mycobacterium sp. after diagnosis of HIV Infection, from January 2000 to December 2006. Results Of 198 patients, acid‐fast staining detected mycobacteria early in 41%. Culture revealed 52.5% to be infected with Mycobacterium tuberculosis (MT). 42.4% had non‐tuberculous mycobacteria (NTM) and 5.1% had MT/NTM positive cultures. Eleven per cent of MT strains were resistant to at least one of the antimycobacterial drugs and 3.1% were multidrug resistant. 39.4% of isolated mycobacteria were NTM species. Conclusion Our data may serve as a starting point for further comparisons with other Brazilian regions and other developing countries. The data may provide important clues to the future understanding, prevention and control of such co‐infections around the world.

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Resistência do Mycobacterium tuberculosis às drogas em pacientes HIV+ em cinco municípios da Baixada Santista, São Paulo, Brasil

Cited by 14 publications

References 29 publications

A study of multidrug-resistant tuberculosis in risk groups in the city of Santos, São Paulo, Brazil

A study of multidrug-resistant tuberculosis in risk groups in the city of Santos, São Paulo, Brazil

Características da tuberculose pulmonar em área hiperendêmica: município de Santos (SP)

Mycobacterium tuberculosis in a HIV‐1‐infected population from Southeastern Brazil in the HAART era

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