Generic drugs in Brazil: known by many, used by few

Bertoldi, Andréa Dâmaso; Barros, Aluísio J D; Hallal, Pedro Curi

doi:10.1590/s0102-311x2005000600029

Cited by 37 publications

(38 citation statements)

References 4 publications

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“…Meanwhile, the unnecessary use of prescription and non-prescription drugs is also a significant factor that increases the risk of poisonings 11 . The risks are thus obviously related to the level of information on medications among patients, prescribers, and dispensers 12,13,14 .…”

Section: Introductionmentioning

confidence: 99%

Acute intentional and accidental poisoning with medications in a southern Brazilian city

Margonato

Thomson²,

Paoliello

2009

Cad. Saúde Pública

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The expansion of the pharmaceutical market in the 20th century led to important changes in the consumption of medications worldwide. The objective of the current study was to analyze acute intentional and accidental poisoning with medications according to factors related to the individual, the poisoning, and the drug involved. This was a cross-sectional study that collected secondary data on all cases of acute poisoning with medications reported from 2003 to 2004 by the Poison Control Center at the Regional University Hospital in Maringá, Paraná State, Brazil. We studied a total of 546 cases of acute poisoning with medications. Females predominated among intentional cases (79.8%), and the 0-9-year age bracket was the most common among accidental cases (51.9%). The most frequently involved drugs were those acting on the central nervous system (57.2%), predominantly those requiring controlled prescriptions, especially among the intentional cases (66.2%). The results demonstrate the characteristics of acute poisoning from medications in Maringá, confirming the need for preventive measures that contribute to the rational use of medications.

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Section: Introductionmentioning

confidence: 99%

Acute intentional and accidental poisoning with medications in a southern Brazilian city

Margonato

Thomson²,

Paoliello

2009

Cad. Saúde Pública

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“…In Brazil, the manufactured drugs are classified as reference drugs, generic and similar medicines (BERTOLDI; BARROS; HALLAL, 2005) and may have different excipients, since since they have to presente pharmaceutical bioequivalence. Due to this, it is important to have a method for determining secnidazole tablet wherein the excipients do not interfere with the analysis.…”

Section: Secnidazolementioning

confidence: 99%

Determination and validation of secnidazole in tablets by UV spectrophotometric

Marcílio¹,

Raiser²,

Fumagalli³

et al. 2017

Biosci. J.

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Secnidazole, a 5-nitroimidazole, is a drug used in the treatment against protozoa, and several bacterial infections. This study purpose was to develop and validate a UV spectrophotometric method to determine secnidazole in pharmaceutical tablet dosage forms once there is no method reported in the pharmacopoeia yet. The quantification was performed using methanol as solvent at 325 nm (maximum wavelength) and three kinds of products marketed in Brazil (reference, generic and similar tablets) containing 1g of secnidazole. The method obeyed Beer's law in the concentration range of 4 -20 µgmL -1 respectively. The method was validated according to the International Conference on Harmonization (ICH) and Brazil National Health Surveillance Agency (ANVISA) guidelines, showing accuracy, precision, selectivity, robustness and linearity. Tests such as weight range, friability, disintegration, hardness and dissolution were carried out to check tablets' quality and all the trials showed to be in accordance with the general test guidelines of the Brazilian Pharmacopoeia. The dissolution test was carried out and the developed method was applied. The method developed is suitable for the estimation of secnidazole in tablets without any interference from the excipients and can be used for routine in quality control. Still, it's a simple, fast and low cost method.

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“…In pharmacies in Oslo, some of 22 patients who had already made use of antihypertensive generic and brand name drugs mentioned experiencing more side effects and weaker effects upon drug substitution 24 . In two studies conducted in Southern Brazil (2002 and 2011), it was observed that 70% of 3,182 respondents and 64.3% of 374 respondents considered the quality of generic drug products to be similar to brand name drug 16,25 .…”

Section: Generic Drugs Have An Overall Worse Quality Than Brand Name mentioning

confidence: 99%

Perception of the value of generic drugs in São Paulo, Brazil

Nardi

Ferraz

2016

Cad. Saúde Pública

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The objective of this study was to assess the perceptions of opinion-leaders, patients and their accompanying family members or carers about generic drugs. Three groups of participants were surveyed: (i) 50 customers while they were visiting commercial pharmacies located in São Paulo city, Brazil, (ii) 25 patients and 25 companions while they were waiting at the university outpatient clinic, and (iii) 50 healthcare opinion-leaders from government, hospitals, health plans, academia, and pharmaceutical companies. The questions explored socio-demographic characteristics and perceptions regarding value attributes of generic drugs compared to brand name drugs. Respondents had an average age of 52 years and 53% were women. Respondents believed generic drugs to be cheaper than brand name drugs (97%), and 31% thought generic drugs to be less effective than brand name drugs. Also, generic drugs were perceived by 54% of respondents to be as safe as brand name drugs and 74% would prefer brand name drugs if there was no price difference. In conclusion, multiple factors may contribute to the decision to buy generic drugs; among these, perceived effectiveness, safety and price appear to be the most important factors.

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Generic drugs in Brazil: known by many, used by few

Cited by 37 publications

References 4 publications

Acute intentional and accidental poisoning with medications in a southern Brazilian city

Acute intentional and accidental poisoning with medications in a southern Brazilian city

Determination and validation of secnidazole in tablets by UV spectrophotometric

Perception of the value of generic drugs in São Paulo, Brazil

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