Endocrine disrupting chemicals: harmful substances and how to test them

Olea-Serrano, Nicolás; Fernández-Cabrera, M.; Pulgar-Encinas, Rosa; Olea‐Serrano, F.

doi:10.1590/s0102-311x2002000200013

Cited by 10 publications

(3 citation statements)

References 3 publications

(4 reference statements)

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“…These compounds interfere with the development of the endocrine system and affect the functioning of organs that respond to hormonal signals. The endocrinal and reproductive effects of endocrine disruptors may be a consequence of their ability to: (a) mimic natural hormones, (b) antagonize their action, (c) alter their pattern of synthesis and metabolism, or (d) modify the expressions of specific receptors [31][32][33].…”

Section: Additives Of Concernmentioning

confidence: 99%

A Detailed Review Study on Potential Effects of Microplastics and Additives of Concern on Human Health

Campanale

Massarelli

Savino

et al. 2020

IJERPH

870

372

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The distribution and abundance of microplastics into the world are so extensive that many scientists use them as key indicators of the recent and contemporary period defining a new historical epoch: The Plasticene. However, the implications of microplastics are not yet thoroughly understood. There is considerable complexity involved to understand their impact due to different physical–chemical properties that make microplastics multifaceted stressors. If, on the one hand, microplastics carry toxic chemicals in the ecosystems, thus serving as vectors of transport, they are themselves, on the other hand, a cocktail of hazardous chemicals that are added voluntarily during their production as additives to increase polymer properties and prolong their life. To date, there is a considerable lack of knowledge on the major additives of concern that are used in the plastic industry, on their fate once microplastics dispose into the environment, and on their consequent effects on human health when associated with micro and nanoplastics. The present study emphasizes the most toxic and dangerous chemical substances that are contained in all plastic products to describe the effects and implications of these hazardous chemicals on human health, providing a detailed overview of studies that have investigated their abundance on microplastics. In the present work, we conducted a capillary review of the literature on micro and nanoplastic exposure pathways and their potential risk to human health to summarize current knowledge with the intention of better focus future research in this area and fill knowledge gaps.

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Section: Additives Of Concernmentioning

confidence: 99%

A Detailed Review Study on Potential Effects of Microplastics and Additives of Concern on Human Health

Campanale

Massarelli

Savino

et al. 2020

IJERPH

870

372

View full text Add to dashboard Cite

show abstract

“…Despite the increased interest in this type of pollutant that has arisen in the scientific community and the extensive work performed over the last two decades, important aspects, including the need to predict effects beyond the simply observed hormonal action that is implicated in the pathogeny of endocrine-related diseases, the level of exhibition of the general population, the identification of the threshold level of the effect, and the mechanisms of action and their adverse effects, have not been thoroughly investigated [7]. In conclusion, although a great deal of research related to the hazard assessment and regulation of EDCs has been published, a large number of uncertainties remain with respect to their actions.…”

Section: Introductionmentioning

confidence: 99%

Analytical Methodologies for the Determination of Endocrine Disrupting Compounds in Biological and Environmental Samples

Sosa‐Ferrera

Mahugo-Santana

Santana‐Rodríguez

2013

BioMed Research International

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Endocrine-disruptor compounds (EDCs) can mimic natural hormones and produce adverse effects in the endocrine functions by interacting with estrogen receptors. EDCs include both natural and synthetic chemicals, such as hormones, personal care products, surfactants, and flame retardants, among others. EDCs are characterised by their ubiquitous presence at trace-level concentrations and their wide diversity. Since the discovery of the adverse effects of these pollutants on wildlife and human health, analytical methods have been developed for their qualitative and quantitative determination. In particular, mass-based analytical methods show excellent sensitivity and precision for their quantification. This paper reviews recently published analytical methodologies for the sample preparation and for the determination of these compounds in different environmental and biological matrices by liquid chromatography coupled with mass spectrometry. The various sample preparation techniques are compared and discussed. In addition, recent developments and advances in this field are presented.

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“…A agência de proteção ambiental dos Estados Unidos (USEPA) cita aproximadamente 87.000 substâncias que deveriam ser avaliadas quanto aos seus potenciais efeitos sobre o sistema endócrino (Sadik & Witt, 1999). O Parlamento Europeu, através da sua diretoria geral de meio ambiente (DGENV), apresentou uma lista de 560 compostos cujas interferências têm sido comprovadas em sistemas hormonais (Serrano et al, 2002), sendo o rol continuamente revisado e ampliado à medida que novos dados estão disponíveis.…”

Section: Introductionunclassified

Hormônios estrógenos no rio do Monjolinho, São Carlos - SP: uma avaliação da problemática dos desreguladores endócrinos ambientais

Filho¹,

Wagner²

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The environmental endocrine disruption is among the main problems arrived with the modern society way of life. The hormonal systems of several organisms are injured by a number of chemicals disposal on hydric bodies in erroneous way. These compounds causes reproductive disturbs, and studies pointed it be cancer inductors. The Brazilian National Environmental Council (CONAMA) do not regulated standards for discharges and concentrations of these substances. This work aims to investigate the probable presence and effects of sexual estrogens hormones, one of the most powerful groups of endocrine disruptors (EDCs), at the Monjolinho River. This small urban river is placed in São Carlos; a town located in the São Paulo state, Southwest Brazil, and receives concentrated and diffuse sewage effluents as industrials as domestics. Samples of water and sediments were analyzed by liquid chromatography, and male fishes captured were investigated to survey the vitellogenin protein (Vtg), a biomarker of exposition. To complement the study, ecotoxicological tests with different approaches were considered. Moreover an environmental risk analyze delineation was made because hormones concentrations, mainly the synthetic ethynilestradiol (EE2), VTG induction, and positive effects in ecotoxicity tests were found.

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Endocrine disrupting chemicals: harmful substances and how to test them

Cited by 10 publications

References 3 publications

A Detailed Review Study on Potential Effects of Microplastics and Additives of Concern on Human Health

A Detailed Review Study on Potential Effects of Microplastics and Additives of Concern on Human Health

Analytical Methodologies for the Determination of Endocrine Disrupting Compounds in Biological and Environmental Samples

Hormônios estrógenos no rio do Monjolinho, São Carlos - SP: uma avaliação da problemática dos desreguladores endócrinos ambientais

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