Concentração de lactato sérico em ovelhas e cordeiros mestiços (1/2 Suffolk) nascidos em eutocia

Silva, L. p.; Lourenço, Maria Lúcia Gomes; Grandi, Marina Cecília; Ulian, Carla Maria Vela; Sudano, Mateus José; Chiacchio, Simone Biagio

doi:10.1590/s0102-09352013000400008

Cited by 3 publications

(2 citation statements)

References 22 publications

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“…As in other species such as human beings, horses, and cattle this elevation during parturition in ewes is physiological and due to the generalized stimulation of the sympathetic nervous system with adrenaline and cortisol release during and after birth, promoting the increase of lactate and globular volume, glucose, and free fatty acids (Comline & Silver 1972). Similarly to this study, Silva et al (2013) reported higher lactate levels in Suffolk crossbred ewes at the time of eutocic parturition (3.0±0.5mmol/L).…”

Section: Resultssupporting

confidence: 80%

Comparison of electrolyte and acid-base balances of Dorper breed ewes between single and twin pregnancies

et al. 2019

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During pregnancy there are modifications in the metabolic profile of sheep that may predispose to the occurrence of metabolic disorders, of which pregnancy toxaemia (PT) is highlighted. Blood gas analysis is detects changes in acid-base and electrolyte balance effectively. The objectives of this study were to study the acid-base and electrolyte balance of sheep during gestation and in the immediate peripartum (up to 48 hours postpartum), comparing single gestation with twins. Sixty healthy sheep of Dorper breed, two to five years old were raised in a semi-intensive system and were divided in two experimental groups: Group 1: 30 ewes, with ultrasonographic diagnosis of single fetus gestation; Group 2: 30 ewes, with ultrasonographic diagnosis of twin pregnancy. The experimental moments were defined as: MI-immediately after artificial insemination (control); MG30 - 30 days of gestation; MG90 - 90 days of gestation; MG120 - 120 days of gestation; MG130 - 130 days of gestation; MG140 - 140 days of gestation; MP - lambing; MPP1 - 24h postpartum; MPP2 - 48h postpartum. At all times 1mL of blood was collected per jugular vein puncture for blood gas evaluation in a portable equipament (I-Stat®). The pH, carbon dioxide pressure (PCO2), bicarbonate (HCO3-), base excess (BE), sodium (Na+), potassium (K+), chloride (Cl-), ionized calcium (Ca+2), lactate, anion gap (AG) were mensured and strong ion difference (SID) were calculed. This work showed that there were changes in acid-base and electrolyte balance in pregnant ewes, due to the decrease in BE, HCO3-, TCO2 and increase of lactate and AG during gestation, but the pH remained normal and did not present any difference among moments in both groups. Comparing the groups, single-gestation ewes presented higher alkaline expenditure at delivery than twin-gestation, evidenced by lower levels of BE and HCO3-. Lower Na+ levels were observed in prepartum; drop in K+ values with advancing gestation; hyperchloremia and hypocalcemia during gestation according to the reference standards for species; decreased iCa+2 levels in the final third of gestation in both groups. It was concluded that the ewes of this study were healthy until the last moment analyzed (48h postpartum), although have shown greater consumption of the alkaline reserve in the peripartum, being more explicit in the single gestation animals. In addition, this situation can be physiological and result in increased energy demand during gestation, more exacerbated by peripartum.

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Section: Resultssupporting

confidence: 80%

Comparison of electrolyte and acid-base balances of Dorper breed ewes between single and twin pregnancies

et al. 2019

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“…Neonatal hyperlactatemia has been shown to be physiological in several studies (Comline & Silver 1972, Peternelli Silva 2012, Silva 2012, Silva et al 2013, Regazzi 2015. In this study, it was demonstrated the production of lactate in the placenta and its distribution to the fetus, as shown by Sparks et al (1983).…”

Section: Discussionsupporting

confidence: 54%

Assessment of serum lactate levels, blood glucose values and blood gas values in sheep, newborn lambs and placenta

et al. 2018

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RESUMO.-[Avaliação da concentração de lactato sérico, glicemia e hemogasometria de ovelhas, cordeiros recém-nascidos e placenta.] Os principais desafios da transição fetal-neonatal são a estabilização do equilíbrio ácido-básico, glicemia e oxigenação ao longo das primeiras 24 horas de vida. Falhas nesse sistema são a maior causa de morte nesse período e os estudos de viabilidade neonatal tem se concentrado nas avaliações destas variáveis. O objetivo do presente estudo foi avaliar a comparação da lactatemia materna, placentária e neonatal ao nascimento e, ainda, observar o comportamento do lactato, glicemia e hemogasometria nas primeiras 24 horas de vida do neonato ovino. Para tanto, as avaliações foram realizadas ao nascimento, 4, 8, 12 e 24 horas após. A lactatemia neonatal se mostrou próxima à placentária (p=0,991) e significativamente diferente da materna (p=0,011), o que sugere uma influência da produção de lactato pela placenta na lactatemia neonatal ao nascimento. Ao longo das 24 horas de vida foi possível observar a depuração de lactato pelo organismo do neonato, aproximando assim dos valores de referência para a espécie. Na hemogasometria foi possível observar discreta acidose metabólica, com normalização já nas primeiras 4 horas e estabilização completa do equilíbrio ácido-básico ao final das 24 horas de vida. ABSTRACT.-Peternelli Silva L., Lourenço M.L.G., Paula R.A., Verdugo M.R., Pereira K.H.N.P. & Chiacchio S.B. 2018. Assessment of serum lactate levels, blood glucose values and blood gas values in sheep, newborn lambs and placenta. Pesquisa Veterinária Brasileira 38 (9):1878-1884. Newborn animals, in the fetal-to-neonatal transition, usually face several challenges in their first 24 hours, including issues with acid-base balance, glycemic levels and oxygenation. Difficulties to overcome such issues have caused several deaths among newborns. Therefore, studies have been carried out in order to evaluate them. The main purpose of this study is to evaluate the correlation between the serum lactate level in the mother, in the placenta and in the newborn. Moreover, the study measured the lactate level, blood glucose level and blood gas level in the first 24 hours. Tests were carried out right after birth, and at 4, 8, 12 and 24 hours after. Lactate levels were quite similar to the placental levels (p=0.991) which, in turn, were significantly different from the mother's (p=0.011). Results showed that, shortly after birth, the production of lactate in the placenta is part of the issue. Along the first 24 hours, the study observed a reduction of the levels of lactate in newborns; the levels were closer to the normal index levels for the species. Regarding the blood gas test results, we observed mild metabolic acidosis at birth; acid-base balance was completely stable at the end of the period.Pesq. Vet. Bras. 38(9):1878-1884, setembro 2018 Assessment of serum lactate levels, blood glucose values and blood gas values in sheep, newborn lambs and placenta

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Influence of prenatal corticosteroid therapy on neonatal vitality and utility as a labor-inducing agent in Santa Inês ewes

Santos,

Bittencourt,

Xavier

et al. 2024

Anim. Reprod.

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Concentração de lactato sérico em ovelhas e cordeiros mestiços (1/2 Suffolk) nascidos em eutocia

Cited by 3 publications

References 22 publications

Comparison of electrolyte and acid-base balances of Dorper breed ewes between single and twin pregnancies

Comparison of electrolyte and acid-base balances of Dorper breed ewes between single and twin pregnancies

Assessment of serum lactate levels, blood glucose values and blood gas values in sheep, newborn lambs and placenta

Influence of prenatal corticosteroid therapy on neonatal vitality and utility as a labor-inducing agent in Santa Inês ewes

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