Alterações citológicas do sangue periférico e da medula óssea de cães com cinomose

Almeida, R.K.; Vasconcelos, A.C.; Carneiro, Rubens Antônio; Paes, Paulo Ricardo de Oliveira; Moro, Luciana

doi:10.1590/s0102-09352009000600001

Cited by 11 publications

(9 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This mild anaemia may be the result of inflammatory disease and, additionally, it reduces the erythrocyte lifespan and its responsiveness to the anaemia due to low erythropoietin synthesis and iron deficiency, thereby culminating in limited erythropoiesis (Almeida et al 2009). …”

Section: Discussionmentioning

confidence: 99%

Relation between anaemia and bone marrow features and serum erythropoietin in dogs with chronic kidney disease

et al. 2017

View full text Add to dashboard Cite

RESUMO.-[Relação entre anemia e achados de medula óssea e eritropoetina sérica em cães com doença renal crônica.] A anemia crônica é umas das complicações mais graves da doença renal crônica, contribuindo para a morbidade e mortalidade causada pela doença; Portanto, a avaliação citológica da medula óssea é necessária para monitorar a progressão da anemia. Assim, esse estudo objetivou correlacionar a anemia em cães em diferentes estágios da doença renal crônica aos achados de bioquímica sérica, mielograma e concentração sérica de eritropoietina. Sessenta e três cães foram agrupados de acordo com a classificação da International Renal Interest Society (IRIS) em estágios 1, 2, 3 e 4. Foram realizadas análises hematológicas, bioquímicas séricas e urinárias, e dosagem sérica de eritropoetina para comparação com os achados medulares obtidos por citologia aspirativa do manúbrio. Os achados citológicos de hipoplasia eritróide foram descritos em 93,65% dos cães, e a anemia foi observada em 84,1% dos cães. Os resultados hematológicos foram correlacionados com azotemia (p<0,05). Concluiu-se que a hipoplasia eritróide teve associação com a anemia persistente em cães em todas as fases de doença renal crônica, com deficiência de ferro em cães em fases iniciais e com a destruição periférica dos eritrócitos causada pela azotemia. Chronic anaemia is one of the most severe complications of chronic kidney disease, contributing to morbidity and mortality caused by the disease; therefore, bone marrow cytological evaluation is needed to monitor the progression of anaemia. This study aimed to correlate the anaemia in dogs at different stages of chronic kidney disease with their serum biochemistry, myelogram results and serum erythropoietin findings. Sixty-three dogs were grouped according to International Renal Interest Society (IRIS) classification in stages 1, 2, 3 and 4. Haematologic, serum and urinary biochemistry and serum erythropoietin were performed for comparison with the findings of bone marrow cytology obtained by aspiration of the manubrium. Cytological findings for erythroid hypoplasia were described in 93.65% of dogs, and the anaemia was observed in 84.1% of them. The haematological findings were correlated with azotaemia (p<0.05). It was concluded that the erythroid hypoplasia has correlation with persistent anaemia in dogs at all stages of chronic kidney disease, with iron deficiency in dogs in the early stages and with peripheral destruction of erythrocytes caused by azotaemia.

show abstract

Section: Discussionmentioning

confidence: 99%

Relation between anaemia and bone marrow features and serum erythropoietin in dogs with chronic kidney disease

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Contudo verificou-se que em 22,6% dos cães com cinomose apresentaram considerável leucopenia, e em apenas 13,2% foi observado leucocitose com neutrofilia. Acredita-se que a leucocitose esteja relacionada com infecções bacterianas oportunistas associadas à infecção pelo vírus da cinomose (Silva et al, 2007, Almeida et al, 2009 (Moro et al, 2003).…”

Section: Resultsunclassified

Parámetros hematológicos de perros presentando corpúsculos de Lentz en frotis sanguíneo

Silva

Araújo

Leite

et al. 2017

Pubvet

View full text Add to dashboard Cite

“…The neutrophil short half-life enhances the effect of a transient reduction in their production and may result in leukopenia (REBAR, 1993). Although there is hyperplasia, it is known that the canine distemper virus may lead to a high apoptotic index, culminating to peripheral blood cytopenias (ALMEIDA et al, 2009). …”

Section: Discussionmentioning

confidence: 99%

Quantitative analysis of bone marrow in pancytopenic dogs

Girardi

Campos

Pescador

et al. 2017

SCA

View full text Add to dashboard Cite

The pancytopenia can be associated with intra and extra medullary disorders. When the etiology is not obvious, the examination of bone marrow is necessary. The study aims to report and discuss quantitative amendments in bone marrow and their causes in dogs with pancytopenia. Bone marrow aspirate was obtained from 65 dogs with pancytopenia over a period of 13 consecutive months for preparation of smears stained by Giemsa and observed in light microscopy. Five hundred cells differential count was held; and assessed myeloid:erythroid ratio, cellularity, megakaryocytes and direct parasitological examination. The data were evaluated by the Chi-square statistical test. Blood tests of 3120 canines with several clinical changes were analyzed to identify pancytopenia, which accounted for 167 (5.4%) dogs. Interpretation of quantitative characteristics was carried out from the bone marrow smear in 65 pancytopenic dogs and the etiology was established in 40 (61.5%) of these, which included infection by E. canis and L. chagasi, idiopathic aplastic anemia, chronic renal failure and co-infections. In 17 (26.2%) animals were not observed medullary changes. The most bone marrow change was observed myeloid and erythroid hypoplasia in 17 (26.2%) dogs, followed by myeloid and erythroid hyperplasia (24.6%). The myelogram association to the blood cell count allowed the identification of medullary findings and its participation on the occurrence of pancytopenia cases. The number of cases resulting from infectious diseases was 38 (58.5%) in canine assessed: significant number due to its endemic characteristic of the study region. Key words: Cytology. Canine. Cytopenia. Hemoparasites. Myelogram. ResumoA pancitopenia pode estar associada a distúrbios intra e extra medulares. Quando a etiologia não é óbvia, o exame da medula óssea é necessário. Este estudo tem como objetivo relatar e discutir alterações quantitativas na medula óssea e suas causas em cães com pancitopenia. De 65 cães pancitopêncicos atendidos durante um período de 13 meses consecutivos, foram realizados aspirados de medula óssea, corados com Giemsa, e observados em microscopia de luz. Quinhentas células foram observadas para contagem diferencial, razão mieloide: eritróide, celularidade, megacariócitos e exame parasitológico direto. Os dados foram avaliados pelo teste estatístico Qui-quadrado. Hemograma de 3120 caninos com diversas alterações clínicas foram analisadas para identificar a pancitopenia, encontrada em 167 (5,4%) cães. A interpretação das características quantitativas foi realizada a partir do esfregaço de medula óssea em 65 cães pancitotopênicos e a etiologia foi estabelecida em 40 (61,5%), incluindo infecção por

show abstract

Alterações citológicas do sangue periférico e da medula óssea de cães com cinomose

Cited by 11 publications

References 12 publications

Relation between anaemia and bone marrow features and serum erythropoietin in dogs with chronic kidney disease

Relation between anaemia and bone marrow features and serum erythropoietin in dogs with chronic kidney disease

Parámetros hematológicos de perros presentando corpúsculos de Lentz en frotis sanguíneo

Quantitative analysis of bone marrow in pancytopenic dogs

Contact Info

Product

Resources

About