Effects of topical levobunolol or fixed combination of dorzolamide-timolol or association of dorzolamide-levobunolol on intraocular pressure, pupil size, and heart rate in healthy cats

Abstract

The effects of topical levobunolol with the fixed combination of 2% dorzolamide-0.5% timolol and the association of 2% dorzolamide with 0.5% levobunolol on intraocular pressure (IOP), pupil size (PS), heart rate (HR), and conjunctival hyperemia in eighteen halthy cats were investigated and compared. IOP, PS, HR, and conjuntival hyperemia were daily recorded at three times (9a.m., 2p.m., and 6p.m.). Three groups were formed (n=6), and one eye of each animal was randomly selected and treated with topical levobunolol (L), or commercial combination of dorzolamide-timolol (DT), or the association of dorzolamide with levobunolol (DL). The first day (0)

Comparison of effects of topical levobunolol to a combination of timolol-dorzolamide on intraocular pressure and pulse rate of healthy dogs

“…Recent studies have showed levobunolol to be as effective at reducing IOP in healthy cats a fixed combination of timololol-dorzolamide (Ribeiro et al 2007). Our results recorded in the dog have showed 0.5% levobunolol to be effective at decreasing IOP, but the effects of levobunolol alone were lower than the timolol-dorzolamide combination.…”

Effects of confinement on physiological and psychological responses and expression of interleukin 6 and brain derived neurotrophic factor mRNA in primiparous and multiparous weaning sows

“…The latency and relative contraction amplitude mainly reflected the parasympathetic function [ 9 ]. Conventional pupillary reflex studies were focused on the clinical studies of human disease [ 10 ], but few reported on animals. In our previous study, we first used the PLR method to evaluate sows’ psychological status and found that confined sows had longer pupillary light reflex time (PLRT) than those of grouped sows [ 5 ].…”

Effects of 0.5% Timolol Maleate Ophthalmic Solution on Heart Rate and Selected Echocardiographic Indices in Apparently Healthy Cats

“…Timolol is a nonselective beta‐blocker, commonly used in dogs and cats for the treatment of glaucoma . In 1 study, instillation of 1 drop of 0.5% timolol ophthalmic solution twice daily decreased heart rate (HR) in healthy cats by a mean of 17 bpm . Ophthalmic administration of timolol has been reported to decrease HR in healthy beagle dogs by 10%…”

“…17,18 In 1 study, instillation of 1 drop of 0.5% timolol ophthalmic solution twice daily decreased heart rate (HR) in healthy cats by a mean of 17 bpm. 19 Ophthalmic administration of timolol has been reported to decrease HR in healthy beagle dogs by 10%. 20 The aims of this study were to (i) evaluate the clinical effectiveness of topical timolol ophthalmic solution in HR reduction and (ii) identify its effects on selected echocardiographic parameters in clinically healthy cats.…”