Minimal inhibitory concentration of azithromycin in Rhodococcus equi strains isolated from foals

Ribeiro, Márcio Garcia; Paes, Antônio Carlos; Listoni, Fernando José Paganini

doi:10.1590/s0102-09352006000600041

Cited by 2 publications

(1 citation statement)

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“…The main advantage of macrolides, rifampicin and other cell-penetrating drugs is the fact that they reach high intracellular concentration in alveolar macrophages and neutrophils (Ribeiro et al, 2006), which is essential for anti-rhodococcal activity. Drugs that inhibited R. equi growth in vitro, (such as combination of penicillin with gentamicin), but were not able to penetrate macrophages, were not effective in the treatment of foals (Giguère et al, 2011).…”

Section: Antimicrobial Susceptibility and Treatmentmentioning

confidence: 99%

Antimicrobial resistance in Rhodococcus equi.

et al. 2014

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Rhodococcus equi is an important etiologic agent of respiratory-and non-respiratory tract infections, diseases of animals and humans. Therapy includes the use of various group of chemotherapeutic agents, however resistance acquirement is quite common. To date there is no preferred treatment protocol for infections caused by isolates resistant to macrolides and rifampicin. The resistance acquirement is a result of many molecular mechanisms, some of which include alterations in the cell envelope composition and structure, activity of the efflux pumps, enzymatic destruction or inactivation of antibiotics, and changes in the target site. This paper contains an overview of antimicrobial susceptibility of R. equi, and explains the possible molecular mechanisms responsible for antimicrobial resistance in this particular microorganism.

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Section: Antimicrobial Susceptibility and Treatmentmentioning

confidence: 99%