Histoplasmose cutânea em gato: relato de caso

Carneiro, Rubens Antônio; Lavalle, Gleidice Eunice; Araújo, Rafael Barbosa de

doi:10.1590/s0102-09352005000800005

Cited by 11 publications

(16 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Histoplasmosis in humans and animals has a higher incidence in midwestern and the Atlantic United States and may be found in all regions in Brazil; however, in humans, the state of Rio de Janeiro is responsible for most of the microepidemics described (Aidé 2009, Brown et al 2012, Greene & Bromel 2012. In dogs and cats the disease is also found in all regions in Brazil (Silva-Ribeiro et al 1987, Carneiro et al 2005, Cordeiro et al 2011, Brilhante et al 2012, Souza et al 2015. Blastomycosis is endemic in humans and animals in the central and the southeastern United States, including Ohio and Mississippi Valleys, and in parts of Canada, Africa and India (Bromel & Sykes 2005, Brown et al 2012.…”

Section: Introductionmentioning

confidence: 99%

Fungal pneumonia in dogs and cats with pulmonary clinical signs in southern Brazil

et al. 2018

View full text Add to dashboard Cite

RESUMO.-[Pneumonia fúngica em cães e gatos do sul do Brasil com sinais clínicos pulmonares.] Pneumonia fúngica tem sido um diagnóstico diferencial em cães e gatos com sinais clínicos pulmonares, sendo também um risco de saúde pública para seus respectivos proprietários. Uma vez que uma fonte comum de exposição ambiental pode resultar em infecção, cães e gatos podem agir como sentinelas da doença para ambos, pessoas e animais. Assim, o presente estudo teve como objetivo avaliar a ocorrência de pneumonia fúngica em cães e gatos com sinais clínicos pulmonares, de maio de 2013 a fevereiro 2015 no sul do Brasil. Radiografias torácicas, exame de sangue e lavado broncoalveolar (LBA) não broncoscópico seguido de análise citológica e microbiológica foram realizados em todos os animais. Um cão foi positivo na cultura do fluido do LBA para um fungo patogênico (Cryptococcus neoformans) e outro cão para um fungo oportunista (Candida parapsilosis). Ambos os cães apresentaram tosse como sinal clínico principal e alterações radiológicas torácicas. Em conclusão, a ocorrência de pneumonia fúngica no sul do Brasil em cães e gatos por meio deste estudo foi relativamente baixa. A cultura do LBA pode possibilitar o diagnóstico de pneumonia fúngica causada por fungos oportunistas ou patogênicos e este diagnóstico diferencial deve ser uma preocupação em cães e gatos com sinais clínicos pulmonares.TERMOS DE INDEXAÇÃO: Pneumonia fúngica, cães, gatos, sul do Brasil, lavado broncoalveolar, saúde pública, micoses. INTRODUCTIONThe most common type of pneumonia detected in dogs and cats is caused by bacteria, however, fungal, parasitic and viral pneumonia require a differential diagnosis in patients with respiratory distress (Cohn 2009

show abstract

Section: Introductionmentioning

confidence: 99%

Fungal pneumonia in dogs and cats with pulmonary clinical signs in southern Brazil

et al. 2018

View full text Add to dashboard Cite

show abstract

“…A histoplasmose humana, também denominada de doença de Darling, é considerada zoonose pela Organização Mundial de Saúde (Carneiro et al, 2005 (Ferreira & Borges, 2009). …”

unclassified

“…Os sinais clínicos em gatos, como fraqueza, letargia, febre, anorexia, emaciação, sinais oculares, envolvimento esquelético e sinais respiratórios são frequentemente crônicos e inespecíficos apesar da doença disseminada (Brömel & Sykes, 2005;Carneiro et al, 2005). Os gatos infectados podem apresentar-se clinicamente sadios ou desenvolver doença disseminada.…”

unclassified

See 1 more Smart Citation

Disseminated feline histoplasmosis: a case report

Silveira¹,

Mottin²,

Ehlers³

et al. 2016

Pubvet

View full text Add to dashboard Cite

RESUMO:Descreve-se um caso de histoplasmose disseminada em um felino fêmea com dois anos de idade, que residia em um sítio no município de São Francisco de Paula, Rio Grande do Sul. O animal apresentava lesões ulceradas e nodulares nas junções mucocutâneas palpebral, oral, anal, na língua e palato duro a cerca de duas semanas. Foram executados: exame de sangue, radiografia torácica, biópsia incisional, cultura micológica e exame histopatológico. Ao exame histopatológico a lesão é constituída por reação inflamatória piogranulomatosa difusa com predomínio de macrófagos contendo numerosas formas fúngicas e caracterizada no exame micológico como Histoplasma capsulatum.Palavras chave: gato, histoplasmose, pneumonia fúngica, testes diagnósticos. Disseminated feline histoplasmosis: a case report ABSTRACT:We describe a case of disseminated histoplasmosis in a female cat with two-year-old, who lived on a farm in the municipality of San Francisco de Paula, Rio Grande do Sul. The animal had ulcerated and nodular lesions in the eyelid muco cutaneous junctions, oral, anal, tongue and hard palate about two weeks. Were performed: blood test, chest radiograph, incisional biopsy, mycological culture and histopathological examination. Histopatological injury examination consists of pyogranulomatous diffuse inflammatory reaction with predominance of macrophages containing numerous fungal forms and characterized in mycological examination as Histoplasma capsulatum.

show abstract

“…A histoplasmose é a segunda doença micótica sistêmica mais frequente em felinos nos Estados Unidos, contudo é pouco descrita em gatos no Brasil, onde não há casos de felinos com comprometimento pulmonar, confirmadamente associados ao Histoplasma capsulatum. Havendo assim uma escassez de estudos, que podem por sua vez refletir o subdiagnóstico da doença e a carência de métodos eficazes e seguros de tratamento [3,5,21,22].…”

Section: Introductionunclassified

Histoplasmose pulmonar grave em um gato doméstico: tratamento com Anfotericina B e Itraconazol

Jardim

Silva

Jesus

et al. 2018

Acta Scientiae. Vet.

View full text Add to dashboard Cite

Background: Histoplasmosis is a systemic mycosis whose etiologic agent is the fungus Histoplasma capsulatum. This fungal infection, which is the second most frequent systemic mycotic fungal disease in felines in the United States, has rarely been found in cats in Brazil. This paper reports on a case of acute pulmonary histoplasmosis in a domestic cat treated with oral itraconazole associated with amphotericin B administered subcutaneously. This treatment resulted in clinical remission of the patient’s symptoms, as evidenced by radiographic follow-ups.Case: A domestic cat suffering from acute dyspnea was taken to a veterinary clinic. The animal was subjected to emergency oxygen therapy, and kept at rest through sedation with midazolam. A physical examination revealed normally colored mucosa, 8% dehydration, bristly fur, body condition score 2/9, tachypnea with respiratory rate of 100 breaths per minute and expiratory dyspnea. The radiographic examination showed marked opacification of all the pulmonary fields, with a mixed pattern (interstitial and alveolar) of heterogeneous appearance and diffuse distribution, which are changes consistent with an inflammatory infectious process (pneumonia). A cytological analysis of the pleural fluid revealed round to oval-shaped intracytoplasmic structures, varying in size from 2 to 4 μm, inside foamy macrophages, consistent with Histoplasma capsulatum. Based on the diagnosis of pulmonary histoplasmosis, and in view of the patient’s acute respiratory distress, it was decided to treat the cat using itraconazole associated with amphotericin B. Itraconazole was administered orally at a dose of 100 mg/cat every 24 h, while amphotericin B was administered subcutaneously at a dose of 0.5 mg/kg, combined with 100 mL of sodium chloride 0.9% and 100 mL of 5% glycated serum, with monitoring of serum concentrations of symmetric dimethylarginine (SDMA). Amphotericin B was administered every 48 h up to the 7th dose, followed by three times a week up to the 11th dose, and then twice a week up to the 16th dose. The animal was released from the veterinary hospital 10 days after its admission, showing a considerably improved respiratory condition and a respiratory rate of 40 breaths per minute. Continuation of the antifungal treatment with itraconazole was prescribed, maintaining the same dose and frequency of administration until a new recommendation would be made, as well as frequent return visits for the administration of amphotericin B and reassessment of the animal. The administration of amphotericin B was discontinued when the animal’s respiratory condition stabilized; hence, the feline received a total of 16 doses of the drug. The animal showed remission of clinical respiratory symptoms, confirmed by follow-up chest X-rays, which revealed significantly less radiodense pulmonary parenchyma in response to treatment with itraconazole and amphotericin B. Five months after beginning its treatment, the cat is being treated orally with itraconazole (100 mg/cat, every 24 h), without recrudescence of the clinical symptoms.Discussion: To date, six cases of feline histoplasmosis have been reported in Brazil, only one of which had pulmonary involvement and was treated successfully. The use of oral itraconazole associated with subcutaneous amphotericin B has proved to be effective for the treatment of acute pulmonary histoplasmosis in domestic cats. Note that a rapid diagnosis of pulmonary disease is essential in order to immediately implement a combined drug therapy linked with monitoring to ensure the protocol is safe for the patient

show abstract

Histoplasmose cutânea em gato: relato de caso

Abstract: A case of a cutenous histoplasmosis in a three-year-old male Siamese cat is described. The diagnosis was based on clinical signs and laboratory exams. Dramatic remission of clinical signs was observed with cetoconazol therapy.

Cited by 11 publications

References 5 publications

Fungal pneumonia in dogs and cats with pulmonary clinical signs in southern Brazil

Fungal pneumonia in dogs and cats with pulmonary clinical signs in southern Brazil

Disseminated feline histoplasmosis: a case report

Histoplasmose pulmonar grave em um gato doméstico: tratamento com Anfotericina B e Itraconazol

Contact Info

Product

Resources

About