Doença de Crohn e farmacobezoar intestinal: relato de caso

Trece, Adriana Santos Neves; Netto, Luciana Paes Peixoto; Trece, Rafael Lima; Bravo, Fernando Pinto; Júnior, Paulo Cesar Castro; Paulo, Francisco Lopes

doi:10.1590/s0101-98802010000200014

Cited by 4 publications

(6 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…With 92% sensibility and 71% specificity, it identifies all the aforementioned findings, besides showing parietal thickening of the site affected by the disease, presence of intraluminal foreign body, signals of inflammatory activity in the mesenterium and complications such as abscesses and fistula 2,3,6,7 , Due to the advancements in imaging diagnostic tests and the poor response to drug therapy, the surgical approach for the fibrostenotic behavior of CD has been indicated earlier for two decades. Trece et al 4 , in 2010, reported a case of pharmacobenzoars with mesalazine pills which, associated to the present description, points to the importance of using the medications properly according to its pharmacological conditions, as well as to their adequate state of conservation, so that their active principle may indeed function to control the disease.…”

Section: Discussionmentioning

confidence: 54%

“…There are few reports in literature concerning bowel obstruction in patients with Crohn's disease caused by medications in form of pills 1 . The formation of pharmacobezoars is related to the chemical and pharmacological properties of the pills, with formulas covered with late absorption or continuous liberation, besides individual predisposing factors, such as inflammatory, tumoral or post-surgical strictures 4 .…”

Section: Discussionmentioning

confidence: 99%

“…Pharmacobezoars may be formed in any portion of the GIT and are frequently associated with predisposing anatomical and functional factors or other concomitant affections 4 . The pharmacological properties of the drugs can contribute with the physiopathology of the formation of bezoars 4 . In literature, cases of bowel obstruction associated with undissolved pills above the stenosis are rare.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Bezoar by mesalazine tablets: cause of intestinal obstruction in Crohn's disease

Albuquerque¹,

Carvalho²,

Batista³

et al. 2012

J. Coloproctol. (Rio J.)

View full text Add to dashboard Cite

The stricturing and fistulizing forms of Crohn's disease (CD) exhibit many different results to clinical treatment and good response to surgical therapy. The prevalence of strictures in CD ranges from 12 to 54% and they are more frequently in patients with longer disease duration, and the terminal ileum is the most commonly affected location. The pharmacobezoars can be formed in any part of the gastrointestinal tract and are often associated with factors predisposing anatomic, functional or other concomitant conditions. The pharmacological properties of drugs may contribute to the pathophysiology of bezoars. The objective of this case report is to alert for the importance of the quality of prescribed medications that are used by patients with CD, through the finding of more than 350 tablets of mesalazine during the surgical treatment of a patient with the fibrostenotic pattern.ReSumo: As formas estenosante e fistulizante da doença de Crohn (DC) apresentam resultado variável ao tratamento medicamentoso e boa resposta à terapia cirúrgica. A prevalência da DC estenosante varia de 12 a 54%, mais frequente nos pacientes com maior tempo de doença, sendo o íleo terminal o local mais acometido. Os farmacobenzoares podem se formar em qualquer porção do trato gastrointestinal e frequentemente estão associados a fatores anatômicos predisponentes, funcionais ou outras afecções concomitantes. As propriedades farmacológicas dos medicamentos podem contribuir na fisiopatologia da formação dos benzoares. O objetivo deste trabalho é alertar para a importância da qualidade dos fármacos prescritos e utilizados pelos pacientes com DC, por meio do achado de mais de 350 comprimidos de mesalazina

show abstract

Section: Discussionmentioning

confidence: 54%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Bezoar by mesalazine tablets: cause of intestinal obstruction in Crohn's disease

Albuquerque¹,

Carvalho²,

Batista³

et al. 2012

J. Coloproctol. (Rio J.)

View full text Add to dashboard Cite

show abstract

“…Crohn's disease (CD) is a chronic inflammatory bowel disease that affects any part of the gastrointestinal system, being more common between 15 and 40 years of age [1]. Classic symptomatology includes diarrhea, vomiting, weight loss, abdominal pain, fever and malnutrition.…”

Section: Introductionmentioning

confidence: 99%

“…The diagnosis is made through clinical data, radiological and histological findings, even without any characteristic that alone makes up the diagnosis of specific inflammatory bowel disease [1]. gastrointestinal tract.…”

Section: Introductionmentioning

confidence: 99%

Intestinal Obstruction Associated with Pharmacobezoar in a Patient with Crohn’s Disease: A Case Report

Epstein¹,

Garbato²,

Maccapani³

et al. 2023

View full text Add to dashboard Cite

Crohn's disease might result from a complex interplay between genetic susceptibility, environmental factors, and altered gut microbiota, leading to dysregulated innate and adaptive immune responses. The reported case presents a patient with intestinal subocclusion associated with a pharmacobezoar who had a good evolution with clinical treatment. This case report aims to demonstrate the complexity of diagnostic search, even with the classic version of the disease. And it also comes to show the need for a thorough medical history and differential diagnosis investigation.

show abstract