Pesquisa de linfonodo-sentinela em pacientes com adenocarcinoma de cólon

Freitas, Antônio Hilário Alves; Nunes, Tarcizo Afonso; Wainstein, Alberto Julius Alves; Barroso, Adelanir Antonio; Ricardo-Filho, Omar de Paula; Dias, Marco Antônio; Dias-Filho, Marco A.; Penna, Waldemar Nascimento Brandão

doi:10.1590/s0101-98802008000200004

Cited by 3 publications

(3 citation statements)

References 31 publications

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“…The results showed the superiority of radioisotope over the dye. 17 Vital staining has been used by most authors, because the radiopharmaceuticals add high costs (600 dollars each exam) and logistics complex.…”

Section: Bookmarksmentioning

confidence: 99%

Ex vivo sentinel lymph node investigation in colorectal cancer

Freitas¹,

Wainstein²,

Nunes

2013

Journal of Coloproctology

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Introduction In Brazil, about 26,000 cases of colorectal cancer are diagnosed per year. Pa- tients considered at the early stage of disease (without lymph node) evolve with tumor relapse or recurrence in up to a quarter of cases, probably due to understaging. Objective Research on ex vivo sentinel lymph node in patients with colorectal adenocarcinoma. Materials and methods We studied 37 patients who underwent curative surgical resection. The marker used to identify lymph nodes was patent blue dye injected into the peritu- moral submucosa of the open surgical specimen immediately after its removal from the abdominal cavity. Results Ex vivo identification of sentinel lymph node with marker occurred in 13 (35.1%) patients. The sensitivity was 40% and 60% false negative. The detailed histological examina- tion of sentinel lymph nodes with multilevel section and immunohistochemistry showed metastasis in one (4.3%) individual, considered ultra-staging. Conclusion The ex vivo identification of sentinel lymph node had questionable benefits, and worse results when include patients with rectal cancer. Restaging of one patient was possible after multilevel section and immunohistochemistry of the sentinel lymph node, but more research is needed to evaluate the role of micrometastases in patients with colorectal cancer.

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Section: Bookmarksmentioning

confidence: 99%

Ex vivo sentinel lymph node investigation in colorectal cancer

Freitas¹,

Wainstein²,

Nunes

2013

Journal of Coloproctology

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“…Due to the dye's affinity for lymphatic pathways, it progresses through the channels, and the uptake of the dye by the macrophages in the lymph nodes allows their visual identification (Freitas 2007). This process is due to two basic principles of lymphatic physiology, the existence of an orderly and predictable pattern of drainage to a regional lymph node and the characteristic filtering function that the first ganglion performs (Tanis et al 2001).…”

Section: Introductionmentioning

confidence: 99%

Uterine lymphangiography: comparison of two methods for locating the medial iliac lymph node

et al. 2014

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ABSTRACT.-Justino R.C., Cardoso G.S., Trautwein L.G.C., Dessunti G.T., Oliveira D.V., Bernardes R. & Martins M.I.M. 2014. Uterine lymphangiography: comparison of two methods for locating the medial iliac lymph node. Pesquisa Veterinária Brasileira 34(11):1121-1126. Departamento de Clínicas Veterinárias, Universidade Estadual de Londrina, Rodovia Celso Garcia, Londrina, PR 86061-900, Brazil. E-mail: imartins@uel.br Different methods for lymphatic mapping in dogs, such as infusing tissues with vital dyes or radioactive substances, have been studied, aiming at the early detection of lymph node metastasis. Thus, one could anticipate therapeutic measures and, consequently, prolong the survival and improve the quality of life of the patients. The objectives of this experiment were to locate the nodes responsible for draining the uterine body and horns and to try to establish the relationship between the uterus and the medial iliac lymph nodes to contribute to the early diagnosis and prognosis of uterine disorders. We studied 15 female dogs divided into two groups (5 dead and 10 intraoperative ovariohysterectomy bitches). The dye used was patent blue V (Patent Bleu V ® ). It was observed that the iliac lymph node chain receives much of the uterine (horns) drainage. This method should be considered for safer studies of uterine sanity. This information suggests that evaluating these lymph nodes will allow correlating changes in their physiological status with uterine pathologies.INDEX TERMS: Sacral lymph node, aortic lymph node, vital dye, bitches.

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“…Colorectal cancer (CRC) is the fourth most common malignant neoplasm in the world, and also the most frequent in the digestive tract, presenting with high mortality rates -about half a million deaths per year 1,2 . According to Andrade and Pereira, the adenocarcinoma responds for 90% of the CRC cases 1 .…”

Section: Introductionmentioning

confidence: 99%

Cutaneous metastases from colonic adenocarcinoma: case report

Gomes¹,

Bin²,

Klug³

et al. 2012

J. Coloproctol. (Rio J.)

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Gomes CMCN; Bin FC; Klug WA; Valois T; Preza MTG. Cutaneous metastases from colonic adenocarcinoma -case report. J Coloproctol, 2012;32(3): 297-300. ABSTRACT:The presence of cutaneous metastases (CM) from a digestive tract cancer is infrequent, appearing in less than 5% of the cases. Given the low incidence of metastasis from colon adenocarcinoma, an unusual case that occurred in the Colorectal Surgery Department of Santa Casa de São Paulo is described in this report, and a brief review of literature is presented. A 78-year-old female patient who underwent right hemicolectomy, developed a tumor with approximately 8 cm in diameter in her gluteus eight months later, which was surgically resected, and the histological diagnosis was metastatic adenocarcinoma of the right colon. Although the literature estimated short survival in cases of CM, the patient developed no signs of tumor recurrence five months after the onset of metastasis in the gluteus, with significant improvement in her quality of life.Keywords: colonic neoplasms; adenocarcinoma; neoplasm metastasis; skin; neovascularization, pathologic. RESUMO: Metástase cutânea de adenocarcinoma de cólon -relato de caso.A presença de metástase cutânea (MC) de neoplasia de trato digestivo é um evento pouco frequente, presente em menos de 5% dos casos da doença. Tendo em vista a baixa incidência da metástase cutânea de adenocarcinoma de cólon, será descrito no presente relato um caso incomum que ocorreu no Serviço de Coloproctologia do Departamento de Cirurgia da Irmandade da Santa Casa de São Paulo e será feita uma breve revisão de literatura. Uma paciente do sexo feminino, 78 anos, submetida à hemicolectomia direita, desenvolveu após oito meses tumoração de aproximadamente 8 cm de diâmetro em sua nádega, que foi ressecada cirurgicamente, tendo diagnóstico histológico de metástase de adenocarcinoma de cólon direito. Apesar de ser estimada pela literatura uma sobrevida curta nos casos de MC, a paciente evolui sem sinais de recidiva do tumor após cinco meses do surgimento da metástase em

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Pesquisa de linfonodo-sentinela em pacientes com adenocarcinoma de cólon

Cited by 3 publications

References 31 publications

Ex vivo sentinel lymph node investigation in colorectal cancer

Ex vivo sentinel lymph node investigation in colorectal cancer

Uterine lymphangiography: comparison of two methods for locating the medial iliac lymph node

Cutaneous metastases from colonic adenocarcinoma: case report

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