Resultados do exame anátomo-patológico e "Polymerase Chain Reaction (PCR)" na forma clinica e subclinica da infecção anal pelo Papilomavirus Humano (HPV): estudo em quatro grupos de pacientes

Magi, João Carlos; Rodrigues, Marcos Ricardo da Silva; Guerra, Geanna Mara Lino e Silva de Resende; Costa, Cyro Paulino da; Costa, Antônio Gadelha da; Villa, Luísa Lina; Formiga, Galdino José Sitonio

doi:10.1590/s0101-98802006000400006

Cited by 4 publications

(3 citation statements)

References 10 publications

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“…O diagnóstico da forma subclínica é possível pela anuscopia de alta resolução que cora a área doente, possibilitando a biópsia dirigida, confirmando-se o diagnóstico pelo anatomopatológico. O exame anatomopatológico, além do diagnóstico do HPV nas formas clínica e subclínica, possibilita identificar a neoplasia intraepitelial, o carcinoma microinvasivo e o carcinoma invasivo (9) .…”

Section: Revisão Da Literaturaunclassified

É o exame anatomopatológico de rotina indispensável em cirurgias orificiais?

Neto¹,

Santiago²,

Prudente³

et al. 2010

Rev bras. colo-proctol.

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Introdução: O exame anatomopatológico é feito rotineiramente em cirurgias orificiais e é importante para diagnosticar doenças anais concomitantes, lesões malignas e doenças sexualmente transmissíveis não previstas anteriormente no exame clínico. O gasto com estes exames é bastante significativo para o serviço público o que evidencia a necessidade de avaliar o custo/benefício da sua utilização rotineira. Objetivos: Avaliar o tempo decorrido entre a entrega do material e a emissão do laudo, o nível de concordância entre a impressão diagnóstica e a conclusão do anatomopatológico, a importância clínica das patologias diagnosticadas secundariamente, o custo de realização dos exames e a relação custo/benefício dos mesmos. Metodologia: Estudo descritivo e retrospectivo de 173 exames anatomopatológicos de pacientes do Hospital Universitário de Aracaju realizados de 2005 a 2007, que foram submetidos à cirurgias orificiais. Resultados: O nível de concordância entre a impressão diagnóstica e a conclusão do anatomopatológico foi elevada e, dos laudos discordantes, poucos apresentaram relevância clínica, havendo somente um caso de neoplasia anorretal. Houve um atraso significativo na emissão dos laudos, sugerindo sobrecarga do serviço e o custo/benefício para realização dos exames foi desfavorável. Conclusão: Sugerimos triagem para um uso racional e criterioso do exame anatomopatológico em cirurgias orificiais baseada na história clínica e fatores de risco do paciente.

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Section: Revisão Da Literaturaunclassified

É o exame anatomopatológico de rotina indispensável em cirurgias orificiais?

Neto¹,

Santiago²,

Prudente³

et al. 2010

Rev bras. colo-proctol.

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“…The human papillomavirus (HPV) is the cause of one of the most prevalent sexually transmitted diseases in the world, and there are studies in the medical literature that correlate it with the development of adenocarcinoma in the colon 2 , 3 , 5 , 18 . However, it is most commonly related to the development of cancer of the anal canal 3 , 12 , 24 and especially the uterine cervix 15 , 16 , 21 , 26 , 27 .…”

Section: Introductionmentioning

confidence: 99%

Association between human Papillomavirus and colorectal adenocarcinoma and its influence on tumor staging and degree of cell differentiation

Junior

Oliveira²,

Freire³

et al. 2014

ABCD, arq. bras. cir. dig.

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BackgroundColorectal cancer is one of the most common types of neoplasia among the worldwide adult population. Among neoplasms of the gastrointestinal tract, it is ranked second in relation to prevalence and mortality, but its etiology is only known in around 5% of the cases. It is believed that 15% of malignant diseases are related to viral oncogenesis.AimTo correlate the presence of HPV with the staging and degree of cell differentiation among patients with colorectal adenocarcinoma.MethodsA retrospective case-control study was conducted on 144 patients divided between a test group of 79 cases of colorectal cancer and a control group to analyze 144 patients aged 25 to 85 years (mean, 57.85 years; standard deviation, 15.27 years and median, 58 years). Eighty-six patients (59.7%) were male. For both groups, tissue samples from paraffin blocks were subjected to DNA extraction followed by the polymerase chain reaction using generic and specific primers for HPV 16 and 18. Dot blot hybridization was also performed with the aim of identifying HPV DNA.ResultsThe groups were shown to be homogenous regarding sex, age and site of HPV findings in the samples analyzed. Out of the 41 patients with HPV, 36 (45.6%) were in the cases and five (7.7%) were in the control group (p<0.001). All the HPV cases observed comprised HPV 16, and HPV 18 was not shown in any of the cases studied. There were no significant differences in comparisons of sex, age and site regarding the presence of HPV in either of the groups. It was not observe any significant difference in relation to staging or degree of cell differentiation among the patients with colorectal cancer.ConclusionHuman papillomavirus type 16 is present in individuals with colorectal carcinoma. However, its presence was unrelated to staging or degree of differentiation.

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“…It is believed that HPV is involved in 10 to 15% of all human neoplasias 1,[9][10][11][12][13] . Considering the dimensions of the problem, it is necessary to efficiently contain the outbreak of HPV infection and its sequelae and immunization offers one such opportunity 5,[13][14][15][16][17][18][19] . Nowadays, the available vaccines against HPV prevent the types of HVP responsible for 90% of the warts, 70% of the high-grade carcinomas and precancerous lesions and 35 to 50% of the low-grade vulvar lesions 3,5,19 .…”

Section: Introductionmentioning

confidence: 99%

Level of behavior and knowledge concerning human papillomavirus among university students of a nursing college

Cirilo

Barbosa

Zambrano

2010

Rev. Soc. Bras. Med. Trop.

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Introduction: Human pappilomavirus is one of the most common sexually transmitted diseases, and persistent HPV infection is considered the most important cause of cervical cancer. It is detected in more than 98% of this type of cancer. This study aimed to determine the level of knowledge concerning human papillomavirus among nursing college students of a private educational institution located in the City of Bauru, SP, and correlate their knowledge according to the course year. Methods: A descriptive study with a quantitative approach, performed with a questionnaire that permitted the quantification of data and opinions, thus guaranteeing the precision of the results without distortions in analysis or interpretation. The survey was applied to randomly selected 1 st , 2 nd , 3 rd , and 4 th -year nursing college students. Twenty students from each level were selected during August 2009, totaling 80 students of both genders. Results: Observation revealed that 4

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Resultados do exame anátomo-patológico e "Polymerase Chain Reaction (PCR)" na forma clinica e subclinica da infecção anal pelo Papilomavirus Humano (HPV): estudo em quatro grupos de pacientes

Cited by 4 publications

References 10 publications

É o exame anatomopatológico de rotina indispensável em cirurgias orificiais?

É o exame anatomopatológico de rotina indispensável em cirurgias orificiais?

Association between human Papillomavirus and colorectal adenocarcinoma and its influence on tumor staging and degree of cell differentiation

Level of behavior and knowledge concerning human papillomavirus among university students of a nursing college

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