Correlação entre o padrão de expressão tecidual e os valores séricos do antígeno carcinoembrionário em doentes com câncer colorretal

Rev bras. colo-proctol.

Alfredo

et al. 2008

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Section: Introductionunclassified

Proporção de linfonodos metastáticos como variável independente de prognóstico no câncer colorretal

Rev bras. colo-proctol.

Alfredo

et al. 2008

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“…The variability in clinical and biological behavior has aroused interest in identifying factors associated with disease progression and prognosis. Recently, clinical, histopathologic, molecular and genetic variables have been associated with survival outcome in CRC patients (1,3,9,10,14,15,20,22,24,29,35,45,46) . Factors such as deep tumor infiltration into the colon wall, lymph node infiltration, metastasis and histological degree have been investigated as prognostic markers (23,35) .…”

Section: Discussionmentioning

confidence: 99%

“…There are an estimated 153,760 new cases each year in the United States and over 50,000 patients died from this disease in 2007 (39) . In recent years, clinical, histopathologic, molecular and genetic variables have been identified that are associated with CRC patient survival (1,3,9,10,14,15,20,24,37,39,45) . These include early diagnosis (37) , age (3) , neoplastic site (46) , degree of histological differentiation (14) deep wall intestinal invasion, (10) lymph node invasion (1,9) , mucus production (15) , carcinoembryonic antigen (CEA) serum levels (24) angiolymphatic invasion (21) and genomic expression profiles (45) .…”

Section: Introductionmentioning

confidence: 99%

“…All the specimens were classified using Dukes (9) and TNM (18) staging. The immunohistochemical study was performed using a previously described technique with anti-CEA monoclonal antibodies and streptavidin-biotin-peroxidase-complex (24) . The distribution patterns of staining were categorized according to the protein distribution tissue pattern and extent of protein polarization in the cells.…”

Section: Introductionmentioning

confidence: 99%

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Morphofunctional malignancy grading is a valuable prognostic factor for colorectal cancer

Piovesan

et al. 2010

Arq. Gastroenterol.

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-Context -Novel strategies are needed to identify more efficient biomarkers to accurately diagnose prognose and improve the treatment outcome of colorectal cancer. Objectives -To analyze the functional and morphological features of colorectal cancer to identify the neoplastic patterns that affect patient survival. Methods -Forty-five patients with colorectal cancer were followed for a minimum of 3 years. Blood levels of carcinoembryonic antigen (CEA) were measured by chemiluminescence and immunohistochemical analysis of tissue expression followed by computer-assisted image processing. Tumors were assigned to three morphofunctional classes. The morphofunctional classification was based on combination between histological differentiation and cell polarization. The functional characterization was based on the CEA cell polarization. The tissue polarization of CEA was classified in well-polarized, moderately polarized or nonpolarized cells. Morphofunctional staging was defined by the association between morphofunctional class (polarization and histological differentiation) and TNM by score given to each one classification. Results -There was an association between increased CEA tissue expression and loss of histological differentiation (P = 0.01) or loss of polarization capacity (P = 0.03). There was a progressive increase in tissue CEA quantities in accordance with the proposed morphofunctional grading system. Plasma levels of CEA were increased in advanced tumor stages. Blood levels of CEA were increased in advanced morphofunctional stages (P = 0.001). There was a relationship between survival outcome and morphofunctional staging (P = 0.005). Conclusion -Morphofunctional staging is a valuable prognostic factor for colorectal cancer and it correlates with plasma CEA levels.

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“…Código A-115). 31 Considerou-se positiva a presença do CEA no tecido quando a imunocoloração identificou granulação homogênea acastanhada tanto no tecido normal quanto neoplásico. A análise microscópica das lâminas foi realizada com o auxílio de um microscópio óptico comum, com ajuda de lente objetiva de 100x e com magnificação final de 400x.…”

Section: Métodounclassified

Proposta para estadiamento do câncer colorretal baseada em critérios morfofuncionais: correlação com níveis séricos do antígeno carcinoembrionário

Rev bras. colo-proctol.

Piovesan

et al. 2007

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