Ansiedade experimental humana

Graeff, Frederico Guilherme

doi:10.1590/s0101-60832007000500008

Cited by 13 publications

(15 citation statements)

References 1 publication

(2 reference statements)

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“…The psychological measurements were performed through the application of do state-trait anxiety inventory (STAI), produced by Spielberg, Gorsuch and Lushene (1970) [17], translated and validated to Portuguese by Biaggio and Natalício (1979) [18]. STAI is a test compound by two self-assessment questionnaires trait anxiety inventory and the state anxiety inventory.…”

Section: Methodsmentioning

confidence: 99%

“…Considering all stages of SPS the analysis between the groups showed no significant differences of the ECS and ET (p> 0.05). (Figure 2) The STAI-T was evaluated only in the initial moment in each of the experimental groups, the analysis of the data shows that the same participants began the test with mild anxiety levels (40-60 points) [17]. There was no difference between groups (p> 0.05).…”

Section: Multiple Dosesmentioning

confidence: 98%

“…The STAI-T experiment was evaluated only in the initial moment in each of the experimental groups, the analysis of the data shows that the same participants began the tests with moderate levels of anxiety (33-49 points) [17] (Table 2). The comparisons between the groups showed no statistical differences (p> 0.05) compared to the scores of the STAI-E. …”

Section: Single Administrationmentioning

confidence: 99%

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Effects of the single supplementation and multiple doses of Passiflora incarnata L. on human anxiety: A Clinical Trial, Double-blind, Placebo-controlled, Randomized

Silva¹,

Costa²,

Alves³

et al. 2017

int arch med

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Object: This study aimed to investigate the effects of Passiflora incarnata L. on anxiety in humans. Method:The individuals were randomly assigned to one of the following groups: Placebo or experimental, n =30, single dose, as well as Placebo or Experimental, n =15, multiple dose. The experimental human anxiety was induced by simulated public speaking test in the following phases: Basal (B), stressful (A), speech 1 (S1), speech 2 (S2) and Final (F). We evaluated the Systolic Blood Pressure (SBP), and Diastolic (DBP), Heart Rate (HR), Electrical Conductance of Skin and extremities temperature (ET) and filled The state-trait anxiety inventory (STAI S e T).Results: During the single dose, the HR was reduced at the end of the speech (86±2.0 to 74±3.0 bpm) the experimental group compared to the placebo group (p<0.05); the STAI-S did not change. In the delineation of multiple doses, SBP was reduced, in mmHg, in the experimental group compared to the placebo group during all phases. Experimental: 106±1.0 (B), 111±1.0 (A), 121±2.0 (S1), 115±3 (S2), 104±2.0 (F) IntroductionAnxiety disorders reach over 25% prevalence, including the fear of public speaking [1]. Anxiety comprises emotional and behavioral factors through fear manifestation, insecurity, apprehensive anticipation, catastrophic thinking, increase in wakefulness or alert period and physiological, as activation of the hypothalamic-pituitary-adrenal (HPA) axis, leading neurovegetative symptoms such as insomnia, tachycardia, pallor, increased perspiration, muscle tension, trembling, dizziness, intestinal disorders, among others [2].The impact of anxiety on the individuals's health covers changes in blood pressure, heart rate and an increased risk of cardiovascular diseases such as coronary heart disease (risk tripled) and cerebrovascular [3].Therefore, researchers have invested in as natural forms taken to treat or ameliorate the symptoms of anxiety, such as the use of herbs. Plants that are most studied with anxiolytic potential are Kawa, the St. John's Wort and Passiflora spp. [4][5][6][7]. The Passiflora extract has been used in many researches, presenting in their chemical constitution polyphenols, polyunsaturated fatty acids, fiber and other substances, such as passiflorin, one indole alkaloid, being the last one associated with anxiolytic effects [3].The effects of Passiflora incarnata L on anxiety was previously assessed in animals [8,4] and in humans [9-10] with satisfactory results [7]. Epidemiological studies have shown that the fear of public speaking is one of the biggest phobias that affect people, being highly prevalent among students [11].The study proposal was to evaluate symptoms of anxiety of public speaking, under a single dose and multiple doses through the simulated public speaking (SPS) test through the intervention with the encapsulated dry extract of the whole plant Passiflora incarnata L. Materials and MethodsSubjects A study population consisted of university students, adults, healthy, between 24 and 31 years, of both sexes, wer...

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Section: Methodsmentioning

confidence: 99%

Section: Multiple Dosesmentioning

confidence: 98%

Section: Single Administrationmentioning

confidence: 99%

See 1 more Smart Citation

Effects of the single supplementation and multiple doses of Passiflora incarnata L. on human anxiety: A Clinical Trial, Double-blind, Placebo-controlled, Randomized

Silva¹,

Costa²,

Alves³

et al. 2017

int arch med

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“…In order to evaluate subjective experiences related to anxiety, the use of psychometric scales is considered a psychological measure [8].…”

Section: Psychological Measures For Anxiety Evaluationmentioning

confidence: 99%

“…Those which subject the individual to emotional stimulation or specific situations are classified as "psychological models". Those which involve drugs, generally with clarified mechanism of action or in controlled conditions, for induction of anxiety are classified as "chemical models" [7,8,9].…”

Section: Introductionmentioning

confidence: 99%

Clinical Models And Evaluation Measures In The Study Of Experimental Anxiety

Neto¹,

Braga²,

Trajano³

et al. 2017

int arch med

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Objectives: the following review aims to present accumulated evidence in the literature around the main human models for induction of anxiety and the measures frequently used for its evaluation. Method:It was made a bibliographic research having as source of research articles listed by Pubmed and Medline databases and research in specific books which have investigated the main human models for experimental anxiety induction and the measurements frequently used for its evaluation.Discussion: Both the psychological and chemical models for anxiety induction present ethical limits and are constituted of fundamental links between basic research and therapeutic tests done with the patients. The psychological and/or physiological measures for evaluating experimentally produced anxiety reflect body changes that express the level of the elicited anxiety. Conclusion:The use of clinical models and evaluation measures in the study of experimental anxiety makes possible, under the scientific research, understanding the neurobiological substrate of anxiety in its pathological manifestation, beyond evaluating drugs with anxyolitic potential.

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Anxiolytic Effect of Citrus aurantium L. on Patients with Chronic Myeloid Leukemia

Pimenta

Alves

Pimenta³

et al. 2016

Phytotherapy Research

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The bone marrow aspiration procedure is used in hematological diseases and consists of a painful, invasive procedure causing anxiety-associated symptoms. The present study assessed the effect of Citrus aurantium L. essential oil on the treatment of anxiety, in the moment that precedes the collection of medullary material in patients with chronic myeloid leukemia (CML). Volunteers from both sexes were divided into groups receiving either the C. aurantium essential oil through inhalation, diazepam (10 mg), or the placebo. The evaluation was performed through psychometric scales [State-Trait Anxiety Inventory (STAI)] and physiological measurements (blood pressure and cardiac and respiratory frequency). Inhalation of C. aurantium was associated with a decrease in the STAI-S scores, suggesting an anxiolytic effect. In support of these results, a change in all the physiological measurements was observed in the group exposed to C. aurantium. In the diazepam group, only the diastolic pressure decreased, and no effect was observed in the placebo group. Therefore, the results showed that C. aurantium exhibits an anxiolytic effect and reduces the signs and symptoms associated with anxiety in patients with CML.

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Ansiedade experimental humana

Cited by 13 publications

References 1 publication

Effects of the single supplementation and multiple doses of Passiflora incarnata L. on human anxiety: A Clinical Trial, Double-blind, Placebo-controlled, Randomized

Effects of the single supplementation and multiple doses of Passiflora incarnata L. on human anxiety: A Clinical Trial, Double-blind, Placebo-controlled, Randomized

Clinical Models And Evaluation Measures In The Study Of Experimental Anxiety

Anxiolytic Effect of Citrus aurantium L. on Patients with Chronic Myeloid Leukemia

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