Recebido em 29/7/08; aceito em 29/4/09; publicado na web em 6/10/09 INDOLOPYRIDOQUINAZOLINE ALKALOIDS FROM Esenbeckia grandiflora MART. (RUTACEAE). The chemical composition of two specimens of Esenbeckia grandiflora, collected in the south and northeast regions of Brazil, was investigated. In this study, three β-indolopyridoquinazoline alkaloids from the leaves (rutaecarpine, 1-hydroxyrutaecarpine) and roots (euxylophoricine D) were isolated for the first time in this genus. In addition, the triterpenes a-amyrin, β-amyrin, a-amyrenonol, β-amyrenonol, 3a-hydroxyursan-12-one, and 3a-hydroxy-12,13-epoxy-oleanane, the coumarins auraptene, umbelliferone, pimpinelin, and xanthotoxin, the furoquinoline alkaloids delbine and kokusaginine, and the phytosteroids sitosterol, stigmasterol, campesterol and 3β-O-β-Dglucopyranosylsitosterol were also isolated from the leaves, twigs, roots and stems of this species. Structures of these compounds were established by spectral analysis.