Correlação entre a depuração plasmática de creatinina utilizando urina coletada durante 24 horas e 12 horas

Abstract

Introduction: Creatinine concentration in plasma has been used to evaluate renal function. However, the endogenous creatinine clearance (CrCl) is more sensitive to this goal. Objective: Correlate the CrCl calculated from urinary collects of 12 h and 24 h. Methods: Ninety five volunteers (34-64 y) collected the urine for 24 h into two bottles: night, from 7 am to 7 pm and day, from 6 am to 7 pm. A fasting blood sample was used to measure plasma creatinine. Correlation between variables was determined by Pearson method (r) and the agreement between night and 24 h CrCl was determined by the Bland-Altman plot. Results: Urines of 4 individuals were discarded because of collect errors. In the final sample (n = 91; 42 males), hypertension was found in 23 and diabetic in 5. The CrCl (mL/min/1.73 m 2 ) was slightly lower in females in the night (77.8 ± 22.7 versus 88.4 ± 23.6; p < 0.05) and similar in males (91.2 ± 22.9 versus 97.3 ± 30.9; p > 0.05). Strong correlations were observed between the CrCl calculated from the night and day urines and the 24 h (r = 0.85 and 0.83; respectively). Agreement between the CrCl calculated from night or day urine and the 24 h urine was observed, respectively, to 85 and 83 individuals. Conclusion: The 12 h urine, mainly obtained at night, gives CrCl values similar to those obtained in the 24 h collect. Since urine collect is easier to outpatients at night, this period should be chosen in the clinical evaluation of the glomerular filtration rate.

Assessment of different detection methods of chronic kidney disease and their importance for an early diagnosis

“…This is slightly softened by using the CG-corrected formula for the body surface. Sodré et al (2007) reported a good correlation between kidney function and the results of the CG formula; however, Silva et al (2010) found a moderate coefficient of correlation between the GFR measured by collecting urine for 24 h and the GFR calculated by the CG formula, which is similar to the results of the present study, in which the CG formula exhibited a lower correlation and agreement with creatinine clearance than all of the other formulae.…”

Performance of creatinine-based equations for estimating glomerular filtration rate compared to endogenous creatinine clearance

“…ClCr is widely used as a measure of renal function in clinical practice, but it tends to overestimate GFR 8 , 14 , mainly due to the proximal tubular secretion of 10% to 40% of urinary creatinine. Another relevant problem with ClCr is the high probability of error in urine collection within 24 hours 14 , despite the lack of quantitative data in the literature 15 - 17 . Our study found that 46% of the measurements had inadequate urine collection.…”

Reconsideration of the current models of estimated kidney function‐based drug dose adjustment in older adults: The role of biological age

“…Measurement of creatinine clearance (Cl cr ) is challenging to carry out due to difficulties with 24‐h urine collections 40 . Some studies have suggested that shorter collecting times, like 12‐ and 2‐h urine collections, may be comparable to 24‐h Cl cr measurements 41,42 . Other variables, such as diet, exercise, and disease conditions, can affect creatinine production, which confounds our interpretation of Cl cr .…”