Chemical and physiological aspects of isomers of conjugated fatty acids

Carvalho, Eduardo Elias Vieira de; Melo, Illana Louise Pereira de; Mancini‐Filho, Jorge

doi:10.1590/s0101-20612010000200002

Cited by 32 publications

(35 citation statements)

References 78 publications

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“…Although several other isoforms of CLAs have been identified (t9,t11, c9,c11, t10,t11 and c10,c12), the c9,t11 and t10,c12 isomers appear to be the most biologically active. 4,27 Researches indicate that these isomers possess different functions in the human body. For example c9,t11 is effective against cancer and t10,c12 possesses anti-carcinogenic, anti-obesity and antidiabetic properties.…”

Section: Resultsmentioning

confidence: 99%

“…3 Many researches indicate that there is an antioxidant molecular mechanism, preventing tumor DNA generation, suppressing carcinogenesis activation, producting immunostimulatory effects and possessing antithrombotic, anti-obesity and anti-diabetic properties. 4 Milk contains essential fatty acids (FA) from the omega-6 (n-6) and omega-3 (n-3) group, which are respectively: the linoleic acid (LA) and the alpha-linolenic acid (LNA). Both are necessary to keep cell membranes, cerebral functions and nerve impulse transmissions under normal conditions.…”

Section: Introductionmentioning

confidence: 99%

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Absolute quantification of fatty acid and proximate composition of cow and goat powdered milks

Batiston¹,

Maruyama²,

Gomes³

et al. 2012

J. Braz. Chem. Soc.

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Este trabalho investigou a qualidade lipídica de leites processados por quantificação de ácidos graxos. Dez amostras de leite em pó integral de vaca e duas de cabra foram submetidas à extração de lipídios totais e à preparação dos ésteres metílicos de ácidos graxos. Estes foram separados em cromatógrafo a gás. A variação da quantidade de ácidos graxos por gramas de lipídios para compostos poliinsaturados, ômega 6, ômega 3 e ácido linoléico conjugado, foi respectivamente: 25,67, 12,45,1,,65 e 7,77-11,60 mg g -1 . A razão n-6/n-3 foi menor para os leites em pó de vaca (2,85-6,07) em relação aos de cabra (11,75) e a quantidade de ácidos graxos trans variou de 0,09 a 0,17 g por porção de 26 g. As amostras apresentaram ácidos graxos essenciais ômega 6 e ômega 3, isômeros do ácido linoléico conjugado e quantidade de ácidos graxos trans em conformidade com a legislação brasileira.This work investigated of the lipid quality of processed milks by fatty acid quantification. Ten samples of dry whole milk from cow and two from goat were submitted to total lipid extraction and to fatty acid methyl ester synthesis. Then, the synthesized products were separated in a gas chromatograph. The variation of the fatty acid per total lipid gram for polyunsaturated compounds, omega-6, omega-3 and conjugated linoleic acid, was 25.20-46.67, 12.82-31.45, 1.77-7.65 and 7.77-11.60, respectively. The n-6/n-3 ratio for the cow powdered milk samples (2.85-6.07) was lesser reagarding goat milk samples (11.31-12.75) and the trans fatty acid amount varied from 0.09 to 0.17 g per 26 g portion. Essential fatty acids from the omega-3 and omega-6 groups were present in every sample, besides conjugated linoleic acid isomers. The trans fatty acid contents of the samples is in accordance with the Brazilian legislation.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Absolute quantification of fatty acid and proximate composition of cow and goat powdered milks

Batiston¹,

Maruyama²,

Gomes³

et al. 2012

J. Braz. Chem. Soc.

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“…Among a great variety of plant seed oils, oils with conjugated fatty acid moieties are of special interest because of their high biological activity [1][2][3][4][5][6][7]. One type of these acids includes isomeric octadecadienoic acids found mostly in the meat and dairy products derived from ruminants (conjugated linoleic acids, CLA) [8].…”

Section: Introductionmentioning

confidence: 99%

“…Development of relative retention analysis [16] was directed to escape the dependence upon mobile phase composition. In this approach, retention of solute has two parametric dependence: logk(i) = a 0 + a 1 logk(A) (1) where k(i) is capacity factors of solute, while k(A) is that of reference solute A. Increment approach implies to use group contribution factor to calculate the solute retention alteration for the exchange of two fatty acids in pair of TGs is the other two moieties remain unchanged:…”

Section: Introductionmentioning

confidence: 99%

Comparison of Separation of Seed Oil Triglycerides Containing Isomeric Conjugated Octadecatrienoic Acid Moieties by Reversed-Phase HPLC

et al. 2017

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Abstract:Relative retention analysis and increment approach were applied for the comparison of triglycerides (TGs) retention of a broad set of plant seed oils with isomeric conjugated octadecatrienoic acids (CLnA) by reversed-phase HPLC for "propanol-2-acetonitrile" mobile phases and Kromasil 100-5C18 stationary phase with diode array detection (DAD) and mass spectrometric (MS) detection. The subjects of investigation were TGs of seed oils: Calendula officinalis, Catalpa ovata, Jacaranda mimosifolia, Centranthus ruber, Momordica charantia, Trichosanthes anguina, Punica granatum, Thladiantha dubia, Valeriana officinalis, and Vernicia montana. It was found that a sequence of elution of TGs of the same types is the same without any inversions for full range of mobile phase compositions: punicic (C18:3 9Z11E13Z ) < jacaric (C18:3 8Z10E12Z ) < catalpic (C18:3 9E11E13Z ) < α-eleostearic (C18:3 9Z11E13E ) < calendic (C18:3 8E10E12Z ) < β-eleostearic (C18:3 9E11E13E ) < all-E calendic (C18:3 8E10E12E ) acids. TGs and fatty acid compositions were calculated for all oil samples. Regularities of solute retentions as a function of isomeric conjugated octadecatrienoic acid moiety structure are discussed. Thus, it was proven that it is possible to differentiate TGs of complex composition with moieties of all natural CLnA by retention control accomplished by electronic spectra comparison, even though there are only three types of electronic-vibration spectra for seven isomeric CLnA.

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“…Among the several milk bioactive lipid components conjugated linoleic acids (CLA) has gained more importance to nutritionists and researchers in recent years due to enhancement of health benefits, which includes anticarcinogenic, antidiabetic and antiatherogenic (Benjamin and Spener, 2009;Carvalho et al, 2010;Reynolds and Roche, 2010). The beneficial effects of milk CLA in dietary are mainly attributed to two CLA isomers which include cis-9, trans-11 (c9, t11-CLA) and trans-10, cis-12 (t10, c12-CLA), their structure is shown in Fig.…”

Section: Introductionmentioning

confidence: 99%

Bioactive Conjugated Linoleic Acid (CLA) in Milk

Kee¹,

Ganesan²,

Kwak³

2010

Korean Journal for Food Science of Animal Resources

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Conjugated linoleic acid (CLA) isomers are found naturally in foods, such as milk, milk products, beef and others, from biohydrogenation of vegetable oils. They are heterogenous group of isomers of linoleic acid in the family of polyunsaturated fatty acids. Among the isomers of linoleic acid cis9, trans11-CLA (c9, t11-CLA) and trans10, cis12-CLA (t10, c12-CLA) are found to be biologically active isomers. These biologically active isomers either individual or combined found to be health beneficial in various diseases, such as cancer, diabetes, obesity, and atherosclerosis, conclusive participation in physiological processes are necessary. This review focused on the current study of CLA in prevention of disease, such as cancer, diabetes and atherosclerosis, and their effective function in body fat reduction, improvement of bone and muscle mass at a cellular, clinical and systematic level.

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Chemical and physiological aspects of isomers of conjugated fatty acids

Cited by 32 publications

References 78 publications

Absolute quantification of fatty acid and proximate composition of cow and goat powdered milks

Absolute quantification of fatty acid and proximate composition of cow and goat powdered milks

Comparison of Separation of Seed Oil Triglycerides Containing Isomeric Conjugated Octadecatrienoic Acid Moieties by Reversed-Phase HPLC

Bioactive Conjugated Linoleic Acid (CLA) in Milk

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