Composição química dos frutos de Campomanesia xanthocarpa Berg-Myrtaceae

Vallilo, Maria Isabel; Moreno, Paulo Roberto Hrihorowitsch; Oliveira, Elisabeth de; Lamardo, Leda C.A.; Garbelotti, Maria Lima

doi:10.1590/s0101-20612008000500035

“…A recent article describes the fruits of C. xanthocarpa as rich in nutritional compounds and monoterpenes constituting their essential oil. 26 Antimicrobial activity against S. aureus, Salmonella choleraesuis, and Candida albicans has already been described in gabiroba leaf extract. 27 The fruit extract formed inhibition zones against all bacteria tested, except B. subtilis, but the MICs were higher than the maximum concentration tested.…”

Section: Resultsmentioning

confidence: 99%

“…[17][18][19] The extract was dissolved in sterile water to a concentration of 60 mg/mL. Thirty adult female albino Swiss mice (Mus domesticus domesticus), weighing [24][25][26][27][28][29][30] . On the day of the test, the animals were divided into three groups of 10 mice each.…”

Section: Methodsmentioning

confidence: 99%

Antidiarrheal Activity ofCampomanesia xanthocarpaFruit

Souza-Moreira

¹

,

Salvagnini

²

,

Santos

³

et al. 2011

Journal of Medicinal Food

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The growing list of drug-resistant microorganisms and the persistence of deaths due to diarrhea are compelling reasons to study plants in search of new therapeutic agents. The chemical constitution and popular use of the edible fruits of Campomanesia xanthocarpa O. Berg motivated this study to assess the antimicrobial and antidiarrheal properties of the fruits. An extract in 70% ethanol was prepared, and its antimicrobial activity was tested against several strains of bacteria by the agar diffusion and microdilution methods. Antidiarrheal activity was analyzed by testing intestinal motility in an animal model. Preliminary phytochemical study indicated the presence of flavonoids, saponins, and tannins in the hydroalcoholic extract. Antimicrobial activity was significant, but the minimum inhibitory concentration proved to be higher than the maximum extract concentration tested. The extract did not show significant activity for intestinal motility. Although this fruit extract did not show great results as an antimicrobial or antidiarrheal agent, the study contributes to the search for new plant agents and could be referred to as a research protocol by investigators in this area.

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“…Furthermore, the fruits of Campomanesia spp. have great economic potential, either as in natural food or in the preparation of sweets, ice cream and home-made liqueurs (Vallilo et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Genotoxic effects ofCampomanesia xanthocarpaextracts onAllium cepavegetal system

Pastori

¹

,

Flôres

²

,

Boligon

³

et al. 2013

Pharmaceutical Biology

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Context: Campomanesia xanthocarpa Berg. (Myrtaceae), popularly known in Brazil as guabiroba, is a plant used as antidiarrheic, anti-inflammatory and antirheumatic agents, and in stomach and hepatic disorders. Objective: The antiproliferative and genotoxic effects of aqueous extracts and essential oil of C. xanthocarpa were evaluated. Materials and methods: Cytotoxicity and genotoxicity of the aqueous extracts (6 and 30 mg/mL) and essential oil (0.25%, v/v) obtained from leaves of C. xanthocarpa were evaluated using the Allium cepa L. (Amaryllidaceae) assay. Mitotic index was calculated as the percentage of dividing cells of total cells observed; chromosome abnormalities were observed and counted during cell division. Additionally, the composition of the essential oil and the quantification of the main compounds of the extracts were determined by gas chromatography/mass spectrometry and high performance liquid chromatography coupled with diode array detector, respectively. Results and discussion: Aqueous extracts (6 and 30 mg/mL) led to a reduction of 67.7% and 34.1% of the mitotic index, respectively, whereas the treatment with essential oil caused a 48.2% reduction in the mitotic index, when compared with negative control. Chromosomal mutations were observed and included anaphase bridges, delay chromosome, break chromosome, as well as metaphase with disorganized chromosomal and binuclear cells. The main compounds of the essential oil were b-caryophyllene (8.87%), viridiflorol (6.40%), spathulenol (5.16%), d-cadinene (4.92%), linalool (4.46%) and a-cadinol (4.25%). Gallic acid (3.19%), chlorogenic acid (1.04%), quercetin (2.97%) and rutin (4.82%) were identified in an aqueous extract (30 mg/mL). Conclusion: Our results demonstrated that genotoxic and antiproliferative activities are present in C. xanthocarpa infusions using the in vivo onion root-tip cell test.

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“…A recent article describes the fruits of C. xanthocarpa as rich in nutritional compounds and monoterpenes constituting their essential oil. 26 Antimicrobial activity against S. aureus, Salmonella choleraesuis, and Candida albicans has already been described in gabiroba leaf extract. 27 The fruit extract formed inhibition zones against all bacteria tested, except B. subtilis, but the MICs were higher than the maximum concentration tested.…”

Section: Resultsmentioning

confidence: 99%

“…[17][18][19] The extract was dissolved in sterile water to a concentration of 60 mg/mL. Thirty adult female albino Swiss mice (Mus domesticus domesticus), weighing [24][25][26][27][28][29][30] . On the day of the test, the animals were divided into three groups of 10 mice each.…”

Section: Methodsmentioning

confidence: 99%

Natural Products fromGarcinia brasiliensisasLeishmaniaProtease Inhibitors

Pereira

¹

,

Assis

²

,

Juliano

³

et al. 2011

Journal of Medicinal Food

View full text Add to dashboard Cite

The growing list of drug-resistant microorganisms and the persistence of deaths due to diarrhea are compelling reasons to study plants in search of new therapeutic agents. The chemical constitution and popular use of the edible fruits of Campomanesia xanthocarpa O. Berg motivated this study to assess the antimicrobial and antidiarrheal properties of the fruits. An extract in 70% ethanol was prepared, and its antimicrobial activity was tested against several strains of bacteria by the agar diffusion and microdilution methods. Antidiarrheal activity was analyzed by testing intestinal motility in an animal model. Preliminary phytochemical study indicated the presence of flavonoids, saponins, and tannins in the hydroalcoholic extract. Antimicrobial activity was significant, but the minimum inhibitory concentration proved to be higher than the maximum extract concentration tested. The extract did not show significant activity for intestinal motility. Although this fruit extract did not show great results as an antimicrobial or antidiarrheal agent, the study contributes to the search for new plant agents and could be referred to as a research protocol by investigators in this area.

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Composição química dos frutos de Campomanesia xanthocarpa Berg-Myrtaceae

Cited by 44 publications

References 9 publications

Antidiarrheal Activity ofCampomanesia xanthocarpaFruit

Antidiarrheal Activity ofCampomanesia xanthocarpaFruit

Genotoxic effects ofCampomanesia xanthocarpaextracts onAllium cepavegetal system

Natural Products fromGarcinia brasiliensisasLeishmaniaProtease Inhibitors

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