MTP -493G/T gene polymorphism is associated with steatosis in hepatitis C-infected patients

Siqueira, Érika Rabelo Forte de; Oliveira, Cláudia Pinto Marques Souza de; Côrrea-Giannella, Maria Lúcia; Stefano, J.T.; Cavaleiro, Ana Mercedes; Fortes, Maria Angela Henriques Zanella; Muniz, Maria Tereza Cartaxo; Silva, F.S.; Pereira, Leila Maria Moreira Beltrão; Carrilho, Flair José

doi:10.1590/s0100-879x2011007500160

Cited by 13 publications

(11 citation statements)

References 39 publications

(39 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, in a study with 174 Brazilian patients from the northeastern region, the G allele was more often present in patients infected with genotype 1 who had higher levels of fibrosis. Additionally, the GG and GT genotypes were considered independent protective factors against steatosis in patients with chronic hepatitis C and HCV genotype 1 and non-1 [32]. Finally, Saad et al [9] also studied this polymorphism, although not in relation to steatosis, and they reported an association between the GT and TT genotypes and severe fibrosis and cirrhosis ( P = 0.0001).…”

Section: Discussionmentioning

confidence: 99%

Genetic variation in the microsomal triglyceride transfer protein (−493G/T) is associated with hepatic steatosis in patients infected with hepatitis C virus

et al. 2017

View full text Add to dashboard Cite

BackgroundIn chronic hepatitis C, the fibrosis progression rates are extremely variable and can be influenced by factors associated with the host, virus and environment. Among the associated metabolic factors, hepatic steatosis is characterized by an accumulation of triglycerides in hepatocytes. In the host, genetic determinants of hepatic steatosis are observed, such as single-nucleotide polymorphisms (SNPs) in the microsomal triglyceride transfer protein (MTTP) gene. The MTTP -493G/T SNP appears to play an important role in the regulation of gene expression and influences the plasma concentration of circulating low-density lipoprotein (LDL). The present study investigated the influence of this SNP in the development of hepatic steatosis in patients with chronic hepatitis C and evaluated the association of hepatic steatosis with certain characteristics of these patients and the hepatitis C virus (HCV).MethodsTwo hundred thirty-nine patients with chronic hepatitis C were genotyped for the MTTP -493G⁄T SNP by a polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay. The association between hepatic steatosis and selected characteristics of the patient and virus was evaluated using bivariate and multivariate analyses.ResultsThe most prevalent MTTP -493G/T genotype was GG (46%) followed by GT (43.5%) and TT (10.5%). Multivariate analysis of the total cohort revealed associations between the presence of hepatic steatosis and inflammatory activity of moderate to high intensity (P < 0.001), advanced age (P = 0.010), elevated gamma glutamyl transpeptidase (GGT) levels (P = 0.010) and low LDL levels (P = 0.022). Hepatic steatosis was also associated with the TT/GT genotype of the MTTP -493G⁄T SNP in patients infected with HCV genotype 3 (P < 0.001).ConclusionsIn chronic hepatitis C patients infected with HCV genotype 3 and with the TT/GT genotype of the MTTP -493G/T SNP, a significant increase in hepatic steatosis was observed, which may indicate that this SNP has a significant influence on the accumulation of triglycerides in hepatocytes. Furthermore, associations were observed between hepatic steatosis and inflammatory activity of moderate to high intensity, advanced age, elevated GGT and low LDL levels.

show abstract

Section: Discussionmentioning

confidence: 99%

Genetic variation in the microsomal triglyceride transfer protein (−493G/T) is associated with hepatic steatosis in patients infected with hepatitis C virus

et al. 2017

View full text Add to dashboard Cite

show abstract

“…In a study involving women treated with a western type diet, higher fasting levels for plasma cholesterol (but not synthesis) and high-absorption status were demonstrated in TT homozygote women compared with G carriers (36). The presence of the G allele of MTTP -493G/T has an association with lower hepatic MTTP expression, which protects against steatosis in chronic hepatitis (37). Now, it is universally acknowledged that the MTTP -493G>T polymorphism is correlated with the risk of NAFLD.…”

Section: Microsomal Triglyceride Transfer Protein (Mttp)mentioning

confidence: 97%

Development of gene polymorphisms in meditators of nonalcoholic fatty liver disease

Wang

Gong

2017

Biomedical Reports

View full text Add to dashboard Cite

Abstract. Nonalcoholic fatty liver disease (NAFLD) is the most prevalent liver disease worldwide, the morbidity of which closely correlates with diversity of ethnicity, minority, family and location. Its histology spans from simple steatosis, to nonalcoholic steatohepatitis, which ultimately results in fibrosis, cirrhosis and hepatocellular carcinoma. The accelerating prevalence of NAFLD is due to an incremental incidence of metabolic syndrome that is distinguished by dyslipidemia, glucose impairment, obesity, excessive oxidative stress and adipocytokine impairment. Additionally, the pathogenesis of NAFLD is thought to be a multifactorial and complicated disease associated with lifestyle habits, nutritional factors and genetics. However, the pathogenesis and underlying mechanism in the development of NAFLD caused by genetics remains unclear. People have been increasingly emphasizing on the relationship between NAFLD and gene polymorphisms in recent years, with the aim of having a comprehensive elucidation of associated gene polymorphisms influencing the pathogenesis of the disease. In the current article, the authors attempted to critically summarize the most recently identified gene polymorphisms from the facets of glucose metabolism, fatty acid metabolism, oxidative stress and related cytokines in NAFLD that contribute to promoting the progression of the disease.

show abstract

“…We reviewed the titles and abstracts of all articles and excluded 20 articles; full-texts and data integrity were also reviewed, and 16 additional articles were excluded. Finally, 11 case-control studies that met all of the inclusion criteria were included in this meta-analysis (Namikawa et al, 2004;Petit et al, 2006;Gambino et al, 2007;Zampino et al, 2008;Mirandola et al, 2009;Carulli et al, 2009;Oliveira et al, 2010;Musso et al, 2007Musso et al, , 2010El-Koofy et al, 2011;Siqueira et al, 2012). Publication years ranged from 2004-2012.…”

Section: Baseline Characteristics Of Studies Includedmentioning

confidence: 99%

“…The MTP -493G>T polymorphism results from a G>T substitution in the intron region of NM_000253.2. Several previous studies have suggested that the MTP -493G>T polymorphism plays critical roles in the pathogenesis of NAFLD (Namikawa et al, 2004;Musso et al, 2007;Gambino et al, 2007;Zampino et al, 2008;Mirandola et al, 2009;Oliveira et al, 2010;Musso et al, 2010;El-Koofy et al, 2011;Siqueira et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Correlation between MTP -493G>T polymorphism and non-alcoholic fatty liver disease risk: a meta-analysis

L¹,

Sj²,

Shi³

et al. 2014

Genet. Mol. Res.

View full text Add to dashboard Cite

ABSTRACT. Several studies have found that microsomal transfer protein (MTP) may be important in the development and progression of non-alcoholic fatty liver disease (NAFLD). In this meta-analysis, we evaluated the relationships between a common polymorphism (-493G>T, rs1800591 G>T) in the MTP gene and NAFLD risk. The PubMed, CISCOM, CINAHL, Web of Science, Google Scholar, EBSCO, Cochrane Library, and CBM databases were searched for relevant articles published before October 1, 2013 without any language restrictions. Meta-analysis was conducted using the STATA 12.0 software. Crude odds ratios (ORs) with 95% confidence intervals (95%CIs) were calculated. Eleven case-control studies were included in this meta-analysis. A total of 636 NAFLD patients and 918 healthy control subjects were examined in this meta-analysis. Our results indicate that the MTP -493G/T polymorphism increases the risk of NAFLD (G allele vs T allele: OR = 1.39, 95%CI = 1.17-1.65, P < 0.001; GG + GT vs TT: OR = 1.46, 95%CI = 1.02-2.09, P = 0.038, respectively). Subgroup analyses indicated that the MTP -493G/T polymorphism was associated with an increased risk of NAFLD in population-based, MTP -493G>T polymorphism and NAFLD risk hospital-based, polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), and large sample-size subgroups under the allele and dominant models (all P < 0.05). However, we found no association between non-PCR-RFLP polymorphism and small samplesize subgroups (all P > 0.05). Our findings indicate that the MTP -493G/ T polymorphism may contribute to the development of NAFLD. Thus, the MTP -493G/T polymorphism may be a biomarker for the early detection of NAFLD.

show abstract

MTP -493G/T gene polymorphism is associated with steatosis in hepatitis C-infected patients

Cited by 13 publications

References 39 publications

Genetic variation in the microsomal triglyceride transfer protein (−493G/T) is associated with hepatic steatosis in patients infected with hepatitis C virus

Genetic variation in the microsomal triglyceride transfer protein (−493G/T) is associated with hepatic steatosis in patients infected with hepatitis C virus

Development of gene polymorphisms in meditators of nonalcoholic fatty liver disease

Correlation between MTP -493G>T polymorphism and non-alcoholic fatty liver disease risk: a meta-analysis

Contact Info

Product

Resources

About