Correlation between MTP -493G>T polymorphism and non-alcoholic fatty liver disease risk: a meta-analysis

Abstract

ABSTRACT. Several studies have found that microsomal transfer protein (MTP) may be important in the development and progression of non-alcoholic fatty liver disease (NAFLD). In this meta-analysis, we evaluated the relationships between a common polymorphism (-493G>T, rs1800591 G>T) in the MTP gene and NAFLD risk. The PubMed, CISCOM, CINAHL, Web of Science, Google Scholar, EBSCO, Cochrane Library, and CBM databases were searched for relevant articles published before October 1, 2013 without any language restrictions. Meta-analysis was conducted using the STATA 12.0 software. Crude odds ratios (ORs) with 95% confidence intervals (95%CIs) were calculated. Eleven case-control studies were included in this meta-analysis. A total of 636 NAFLD patients and 918 healthy control subjects were examined in this meta-analysis. Our results indicate that the MTP -493G/T polymorphism increases the risk of NAFLD (G allele vs T allele: OR = 1.39, 95%CI = 1.17-1.65, P < 0.001; GG + GT vs TT: OR = 1.46, 95%CI = 1.02-2.09, P = 0.038, respectively). Subgroup analyses indicated that the MTP -493G/T polymorphism was associated with an increased risk of NAFLD in population-based, MTP -493G>T polymorphism and NAFLD risk hospital-based, polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), and large sample-size subgroups under the allele and dominant models (all P < 0.05). However, we found no association between non-PCR-RFLP polymorphism and small samplesize subgroups (all P > 0.05). Our findings indicate that the MTP -493G/ T polymorphism may contribute to the development of NAFLD. Thus, the MTP -493G/T polymorphism may be a biomarker for the early detection of NAFLD.

Genetic variation in the microsomal triglyceride transfer protein (−493G/T) is associated with hepatic steatosis in patients infected with hepatitis C virus

“…A functional SNP in the promoter region of MTTP (−493G/T) has been found to play an important role in the regulation of gene expression and influences the concentration of circulating LDL in the plasma of healthy individuals [10]. Zheng et al [11] and Li et al [12] conducted a meta-analysis and concluded that the MTTP -493G/T SNP is strongly associated with an increased risk of hepatic steatosis, which may contribute to the development of non-alcoholic fatty liver disease (NAFLD). Corroborating these data, Hsiao et al [13] found that MTTP SNPs, including MTTP -493G/T, could modulate lipid homeostasis and influence serum lipid levels and NAFLD risk.…”

Differences in the genetic backgrounds of patients with alcoholic liver disease and non‐alcoholic fatty liver disease

“…It is expressed in enterocytes and hepatocytes, affects lipid absorption, and is related to NAFLD and diabetes . A meta‐analysis showed that an MTP polymorphism (genotype GG) was associated with NAFLD development by reducing the export of lipids to serum and triggering the accumulation of lipids inside hepatocytes . Moreover, this polymorphism was associated with an atherogenic lipid profile in non‐alcoholic steatohepatitis (NASH) .…”

“…25 A meta-analysis showed that an MTP polymorphism (genotype GG) was associated with NAFLD development by reducing the export of lipids to serum and triggering the accumulation of lipids inside hepatocytes. 26 Moreover, this polymorphism was associated with an atherogenic lipid profile in non-alcoholic steatohepatitis (NASH). 27 In NAFLD, SNPs related to lipid metabolism might play a more important role, whereas SNPs related to ethanol metabolism might be more relevant in ALD.…”

The Association between Pediatric NAFLD and Common Genetic Variants

“…The literature reports several SNPs affecting its activity, with contrasting results. A recent meta-analysis confirmed that the promoter −493G > T polymorphism might be associated with NAFLD risk [70,71,72,73,74]. The minor allele (GG) has been linked to an increased postprandial lipid production and larger VLDL circulating levels.…”