Effects of chronic corticosterone and imipramine administration on panic and anxiety-related responses

Effects of chronic treatment with corticosterone and imipramine on fos immunoreactivity and adult hippocampal neurogenesis

“…It is noteworthy that a previous study by our research group showed increases in fos-ir in the lateral septum of animals submitted to the avoidance task of the ETM [28]. Also, consistent with the increases in fos-ir observed after CORT treatment in the ventrolateral septum, the behavior exhibited by pellet-implanted animals in the ETM [19] critically differs from the behavior of sham animals. From their first exposure to the ETM, CORT animals already take a significantly longer time to leave the enclosed arm, thus showing higher levels of anticipatory anxiety (or an increased reaction to novelty) [19].…”

“…Also, consistent with the increases in fos-ir observed after CORT treatment in the ventrolateral septum, the behavior exhibited by pellet-implanted animals in the ETM [19] critically differs from the behavior of sham animals. From their first exposure to the ETM, CORT animals already take a significantly longer time to leave the enclosed arm, thus showing higher levels of anticipatory anxiety (or an increased reaction to novelty) [19]. Since ETM avoidance models GAD, it is thus possible to suggest that CORT-implanted animals may be used for the study of this subtype of pathological anxiety.…”

“…A previous study by our research group [19] has shown that chronic treatment with corticosterone (CORT) facilitates ETM avoidance performance, an anxiogenic effect, while leaving escape unchanged. Imipramine significantly reversed the anxiogenic effects of CORT.…”

“…In order to understand the neurobiological mechanisms responsible for the behavioral effects obtained in the ETM [19], in the present study c-fos protein immunoreactivity (fos-ir) was used to map areas activated by chronic CORT (200 mg Page 5 of 36 A c c e p t e d M a n u s c r i p t 5 pellets, 21-day release) and imipramine (15 mg/kg, IP) administration (Experiment 1).…”

Effect of Imipramine, Paroxetine, and Lithium Carbonate on Neurobehavioral Changes of Streptozotocin in Rats: Impact on Glycogen Synthase Kinase-3 and Blood Glucose Level

“…Such a result reflects the sedative action of imipramine. This finding is in accordance with other reports [41,42]. Imipramine resulted in a significant reduction in the immobility behavior associated with a significant increase in the swimming behavior without modifying the climbing behavior in FST.…”