Gender-dependent effects of aging on the kidney

Gava, Agata L.; Freitas, Flávia Vitorino; Meyrelles, Silvana S.; Silva, I.V.; Graceli, Jones Bernardes

doi:10.1590/s0100-879x2011007500101

Cited by 27 publications

(34 citation statements)

References 58 publications

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“…19 The equivalent rate of ADRs in both genders of elderly patients in this database may be partially explained by potentially smaller differences in hormone levels, renal function, and body composition between females and males with advancing age. 20,21 Other studies involving a number of different pharmacological agents have reported that female gender as a risk factor for ADRs persists for elderly patients, 22,23 while an American prospective cohort study found no influence of age or gender on ADR rates in multivariate analyses of ambulatory patients. 24 Therefore, further research may be required to fully elucidate the role of female gender on susceptibility for ADRs generally, and specifically, with regard to contrast media reactions rather than those to pharmacological agents.…”

Section: Discussionmentioning

confidence: 99%

Gadobutrol for contrast-enhanced magnetic resonance imaging in elderly patients: review of the safety profile from clinical trial, post-marketing surveillance, and pharmacovigilance data

2015

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AIM: To assess the safety of gadobutrol administration in elderly patients (!65 years) by comparing the incidence of adverse drug reactions (ADRs) following gadobutrol-enhanced magnetic resonance imaging (MRI) procedures in elderly patients with that in adults aged 18e64 years.MATERIALS AND METHODS: Safety data on gadobutrol administration from clinical trials, post-marketing surveillance (PMS) studies, and pharmacovigilance reports were collected in three databases. In each dataset, absolute and relative frequencies of ADRs between age groups were analysed, along with odds ratios and 95% confidence intervals. Logistic regression was used to identify significant influencing factors on ADRs in the PMS and pharmacovigilance data.RESULTS: Rates of reported ADRs were lower in elderly patients versus adults aged <65 years due to a reduced incidence of non-serious ADRs; this was statistically significant for the clinical trials and pharmacovigilance populations, with a trend in the PMS database. Serious ADRs occurred infrequently in the clinical trials and PMS populations (too low for statistical comparison), and pharmacovigilance data demonstrated a low incidence (<0.005%) in both age groups.CONCLUSIONS: This evaluation involving three large databases demonstrated no greater incidence of ADRs following gadobutrol-enhanced MRI in elderly patients (!65 years) compared with younger adults, with gadobutrol having a favourable safety profile in both age groups.

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Section: Discussionmentioning

confidence: 99%

Gadobutrol for contrast-enhanced magnetic resonance imaging in elderly patients: review of the safety profile from clinical trial, post-marketing surveillance, and pharmacovigilance data

2015

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“…Furthermore, it has been reported that ND promotes hypertrophy of the proximal and distal convoluted tubules in females, an effect attributed to the androgen receptors expressed in the kidney (Hoseinia et al 2009). As reviewed by Gava et al 2011, testosterone may have negative effect on the kidney. Although we cannot exclude the direct action of ND on the androgen receptor to induce the kidney fibrosis A C C E P T E D M A N U S C R I P T…”

Section: Discussionmentioning

confidence: 99%

Nandrolone decanoate induces cardiac and renal remodeling in female rats, without modification in physiological parameters: The role of ANP system

et al. 2015

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“…Several investigations have shown that E 2 and P 4 modify body fluids and electrolytes (5,6,10,19). Female sex hormones have been shown to regulate the expression of different transporters in different tissues in rats, such as renal tissue (7,8).…”

Section: Discussionmentioning

confidence: 99%

“…E 2 , in vitro , increases the expression of the NaCl cotransporter and Na + -K + -ATPase in renal distal tubule cells in culture by non-genomic mechanisms (8). Investigations showed that the kidneys control the expression of nuclear ERs (ER-α and ER-β) and the transmembrane GPR30 (10,11). This effect in the proximal tubules could be mediated directly via its receptors, or it could also act indirectly though the renin-angiotensin-aldosterone system (32).…”

Section: Discussionmentioning

confidence: 99%

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Roles of estrogen and progesterone in modulating renal nerve function in the rat kidney

Graceli

Cicilini

Bissoli

et al. 2013

Braz J Med Biol Res

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The maintenance of extracellular Na+ and Cl- concentrations in mammals depends, at least in part, on renal function. It has been shown that neural and endocrine mechanisms regulate extracellular fluid volume and transport of electrolytes along nephrons. Studies of sex hormones and renal nerves suggested that sex hormones modulate renal function, although this relationship is not well understood in the kidney. To better understand the role of these hormones on the effects that renal nerves have on Na+ and Cl- reabsorption, we studied the effects of renal denervation and oophorectomy in female rats. Oophorectomized (OVX) rats received 17β-estradiol benzoate (OVE, 2.0 mg·kg-1·day-1, sc) and progesterone (OVP, 1.7 mg·kg-1·day-1, sc). We assessed Na+ and Cl- fractional excretion (FENa+ and FECl-, respectively) and renal and plasma catecholamine release concentrations. FENa+, FECl-, water intake, urinary flow, and renal and plasma catecholamine release levels increased in OVX vs control rats. These effects were reversed by 17β-estradiol benzoate but not by progesterone. Renal denervation did not alter FENa+, FECl-, water intake, or urinary flow values vs controls. However, the renal catecholamine release level was decreased in the OVP (236.6±36.1 ng/g) and denervated rat groups (D: 102.1±15.7; ODE: 108.7±23.2; ODP: 101.1±22.1 ng/g). Furthermore, combining OVX + D (OD: 111.9±25.4) decreased renal catecholamine release levels compared to either treatment alone. OVE normalized and OVP reduced renal catecholamine release levels, and the effects on plasma catecholamine release levels were reversed by ODE and ODP replacement in OD. These data suggest that progesterone may influence catecholamine release levels by renal innervation and that there are complex interactions among renal nerves, estrogen, and progesterone in the modulation of renal function.

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Gender-dependent effects of aging on the kidney

Cited by 27 publications

References 58 publications

Gadobutrol for contrast-enhanced magnetic resonance imaging in elderly patients: review of the safety profile from clinical trial, post-marketing surveillance, and pharmacovigilance data

Gadobutrol for contrast-enhanced magnetic resonance imaging in elderly patients: review of the safety profile from clinical trial, post-marketing surveillance, and pharmacovigilance data

Nandrolone decanoate induces cardiac and renal remodeling in female rats, without modification in physiological parameters: The role of ANP system

Roles of estrogen and progesterone in modulating renal nerve function in the rat kidney

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