Prognosis of colorectal cancer with liver metastasis: value of a prognostic index

Wang, Y.; Liu, Y.F.; Yu, Changhong; Yi, Dehui; Li, P.; Song, W.Q.; Fu, Danyang; Wang, X.

doi:10.1590/s0100-879x2010007500103

Cited by 21 publications

(21 citation statements)

References 21 publications

(18 reference statements)

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“…Figure describes the search results. The scientific literature review and web‐based search identified 53 tools predicting survival in colon or rectal cancer, reported across 63 articles . Two articles reported on the development of two tools each .…”

Section: Resultsmentioning

confidence: 99%

Personalizing prognosis in colorectal cancer: A systematic review of the quality and nature of clinical prognostic tools for survival outcomes

Mahar

Compton

Halabi

et al. 2017

Journal of Surgical Oncology

106

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Integrating diverse types of prognostic information into accurate, individualized estimates of outcome in colorectal cancer is challenging. Significant heterogeneity in colorectal cancer prognostication tool quality exists. Methodology is incompletely or inadequately reported. Evaluations of the internal or external validity of the prognostic model are rarely performed. Prognostication tools are important devices for patient management, but tool reliability is compromised by poor quality. Guidance for future development of prognostication tools in colorectal cancer is needed.

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Section: Resultsmentioning

confidence: 99%

Personalizing prognosis in colorectal cancer: A systematic review of the quality and nature of clinical prognostic tools for survival outcomes

Mahar

Compton

Halabi

et al. 2017

Journal of Surgical Oncology

106

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show abstract

“…A further meta-analysis used a cut-off value of 200 ng/mL to stratify the two groups and also demonstrated an improved survival time with a lower CEA level [13]. The literature also includes cut-off values of 20 ng/mL and 100 ng/mL, highlighting the limitations of comparing these different studies [14]. It is important to acknowledge that other studies have failed to identify a significant survival disadvantage of a raised preoperative CEA level [15]- [18].…”

Section: Introductionmentioning

confidence: 99%

“…Other prognostic factors for long-term survival have been identified previously for colorectal cancer patients with liver metastases. These include degree of primary tumour differentiation, resection margin, nodal involvement, tumour grade and size, number of liver metastases and resection of the liver metastases or not [13] [14]. Other serum tumour markers, including CA19-9 have been studied, as well as markers of proliferative activity (TK, TPS, TPA), however, CEA is the marker that most often used as a prognostic indicator [20].…”

Section: Introductionmentioning

confidence: 99%

Carcinoembryonic Antigen as a Prognostic Factor in Colorectal Cancer with Liver Metastases

McNally¹,

Lloyd²,

Grondona³

2015

JCT

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Aim: The objective of this study was to investigate the prognostic value of serum carcinoembryonic antigen (CEA) level in colorectal cancer patients with liver metastases. The serum CEA level was recorded at the point of metastasis diagnosis, differing from the majority of literature looking at preoperative metastasectomy CEA level. Methods: From January 2010 to December 2014, 138 patients with a diagnosis of colorectal cancer and liver metastases were included in the study-population from Buenos Aires, Argentina. Patients with both resectable and unresectable liver metastases were followed up over a 4-year period. Kaplan Meier survival analysis was used to produce survival curves that were compared by log-rank test. Results: The overall survival for all patients studied with a CEA < 100 ng/ml was significantly longer compared to patients with CEA ≥ 100 ng/ mL (p < 0.001). The 1-, 2-, and 3-year overall survival rates for the whole cohort were 73.6, 56.6 and 53.8% respectively. For patients with unresectable metastases, a low CEA level (<100 ng/mL) was also associated with the increased overall survival (p = 0.036). Conclusions: In our patient cohort, this study indicated that a low CEA level (<100 ng/mL) measured at metastasis diagnosis was a good prognostic indicator for improving survival in patients with colorectal liver metastases. These findings highlight the importance of measuring serum CEA levels in this group of patients at the time of liver metastasis diagnosis.

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“…In recent decades, claims have been made of numerous variables being related to survival. The extent of bowel wall penetration, lymph node metastases, distant metastases, tumor differentiation and tumor stage have been regarded as factors of the utmost prognostic importance; and they have been the basis of most staging systems [13][14][15][16][17][18][19][20][21][22][23][24][25][26][27] . Despite numerous attempts to detect cancer at an early stage, the overall long-term outcome of patients curatively resected has not significantly changed in the last decade, the 5-year survival rate being approximately 60 percent.…”

Section: Introductionmentioning

confidence: 99%

“…More than half of colorectal adenocarcino-mas are still diagnosed only when the disease involves regional or distant structures [22] . Many studies have been performed, using univariate and multivariate methods to define the prognostic significance of various clinical and pathologic factors [13][14][15][16][17][18][19][20][21][23][24][25][26][27][28][29][30][31][32][33] . However, the accurate determination of prognostic factors for colorectal cancer remains a problem.…”

Section: Introductionmentioning

confidence: 99%

An overview of colorectal cancer survival rates and prognosis in Asia

Moghimi-Dehkordi

Safaee²

2012

WJGO

155

100

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Colorectal cancer is a rapidly rising trend in Asia. The incidence in many Asian countries is on par with the West. Several studies have provided data regarding the survival of patients with colorectal cancer. In Asia, the overall cure rate of colorectal cancer has not improved dramatically in the last decade, 5-year survival remaining at approximately 60%. Colorectal cancer survival time has increased in recent years, but mortality rate remains high. Although studies have determined a number of factors that can predict survival of patients after diagnosis, life expectancy has not been increased dramatically. It seems that among the prognostic factors explored so far, the most important are those that relate to early diagnosis of cancer. Primary detection is feasible since efficient screening modalities are available. Colonoscopic surveillance is needed, especially in subjects at higher risk.

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Prognosis of colorectal cancer with liver metastasis: value of a prognostic index

Cited by 21 publications

References 21 publications

Personalizing prognosis in colorectal cancer: A systematic review of the quality and nature of clinical prognostic tools for survival outcomes

Personalizing prognosis in colorectal cancer: A systematic review of the quality and nature of clinical prognostic tools for survival outcomes

Carcinoembryonic Antigen as a Prognostic Factor in Colorectal Cancer with Liver Metastases

An overview of colorectal cancer survival rates and prognosis in Asia

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