Highly sensitive C-reactive protein and male gender are independently related to the severity of coronary disease in patients with metabolic syndrome and an acute coronary event

Monteiro, Camila Nascimento; Pinheiro, Luiz; Izar, Maria Cristina; Barros, Sahana W.; Vasco, M; Fischer, Sven; Póvoa, Rms; Brandão, Sérgio Augusto Bueno; Santos, Ana Beatriz; Oliveira, Luciene de Lima; Carvalho, Antônio Carlos Camargo; Fonseca, Francisco A.

doi:10.1590/s0100-879x2010005000008

Cited by 12 publications

(10 citation statements)

References 35 publications

(26 reference statements)

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“…We were unable to replicate these findings in our study although we did not test as wide a range of variables as previous studies. We were, however, unable to demonstrate lower HDLC [30] and elevated hs-CRP [31] in relation to the 9β polymorphism to support the notion of a pro-inflammatory state.…”

Section: Discussioncontrasting

confidence: 86%

9β Polymorphism of the Glucocorticoid Receptor Gene Appears to Have Limited Impact in Patients with Addison’s Disease

et al. 2014

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BackgroundAddison’s disease (AD) has been associated with an increased risk of cardiovascular disease. Glucocorticoid receptor polymorphisms that alter glucocorticoid sensitivity may influence metabolic and cardiovascular risk factors in patients with AD. The 9β polymorphism of the glucocorticoid receptor gene is associated with relative glucocorticoid resistance and has been reported to increase the risk of myocardial infarction in the elderly. We explored the impact of this polymorphism in patients with AD.Materials and Methods147 patients with AD and 147 age, gender and ethnicity matched healthy controls were recruited. Blood was taken in a non-fasted state for plasma lipid determination, measurement of cardiovascular risk factors and DNA extraction.ResultsGenotype data for the 9β polymorphism was available for 139 patients and 146 controls. AD patients had a more atherogenic lipid profile characterized by an increase in the prevalence of small dense LDL (p = 0.003), increased triglycerides (p = 0.002), reduced HDLC (p<0.001) an elevated highly sensitive C-reactive protein (p = 0.01), compared with controls. The 9β polymorphism (at least one G allele) was found in 28% of patients and controls respectively. After adjusting for age, gender, ethnicity, BMI and hydrocortisone dose per metre square of body surface area in patients, there were no significant metabolic associations with this polymorphism and hydrocortisone doses were not higher in patients with the polymorphism.ConclusionsThis study did not identify any associations between the 9β polymorphism and cardiovascular risk factors or hydrocortisone dose and determination of this polymorphism is therefore unlikely to be of clinical benefit in the management of patients with AD.

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Section: Discussioncontrasting

confidence: 86%

9β Polymorphism of the Glucocorticoid Receptor Gene Appears to Have Limited Impact in Patients with Addison’s Disease

et al. 2014

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“…A proinflammatory state promotes insulin resistance and increases cardiovascular risk. 2,3,8,32 In addition, the presence of metabolic syndrome in patients with type 1 diabetes promotes insulin resistance and leads to increased insulin requirements, with subsequent deterioration of glycaemic control and weight gain. 33 Adiponectin concentrations were inversely correlated with BMI and proinflammatory cytokine (TNF-a and IL-6) and inflammatory marker (hs-CRP) concentrations in the present study.…”

Section: Discussionmentioning

confidence: 99%

Metabolic syndrome, adiponectin and proinflammatory status in patients with type 1 diabetes mellitus

Timar

Degeratu³

et al. 2014

J Int Med Res

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Objectives: To assess the prevalence of metabolic syndrome and evaluate proinflammatory status in patients with type 1 diabetes, and to analyse the relationship between inflammation, metabolic control and insulin resistance in these patients. Methods: Patients with type 1 diabetes were stratified according to the presence or absence of metabolic syndrome. Serum adiponectin, leptin, tumour necrosis factor (TNF)-a, interleukin (IL)-6 and high-sensitivity C-reactive protein (hsCRP) were quantified. Results: The prevalence of metabolic syndrome was 28.6% (22/77). Patients with metabolic syndrome had lower adiponectin concentrations and higher leptin, TNF-a, IL-6 and hsCRP concentrations compared with patients without metabolic syndrome. In addition, metabolic syndrome was associated with higher glycosylated haemoglobin and insulin dose, and increased insulin resistance. Conclusions: The proinflammatory state associated with metabolic syndrome in patients with type 1 diabetes leads to deterioration of glycaemic control and an increase in the required daily dose of insulin. Early and proactive diagnosis of metabolic syndrome in these patients will allow medication and lifestyle optimization, in order to prevent the occurrence of diabetes complications and improve health-related quality-of-life.

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“…[89] There are very few studies showing association of metabolic syndrome and number of its components with severity of disease in India. [810]…”

Section: Introductionmentioning

confidence: 99%

Association of metabolic syndrome with severity of coronary artery disease

Mahalle

Garg

Naik

et al. 2014

Indian J Endocr Metab

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Highly sensitive C-reactive protein and male gender are independently related to the severity of coronary disease in patients with metabolic syndrome and an acute coronary event

Cited by 12 publications

References 35 publications

9β Polymorphism of the Glucocorticoid Receptor Gene Appears to Have Limited Impact in Patients with Addison’s Disease

9β Polymorphism of the Glucocorticoid Receptor Gene Appears to Have Limited Impact in Patients with Addison’s Disease

Metabolic syndrome, adiponectin and proinflammatory status in patients with type 1 diabetes mellitus

Association of metabolic syndrome with severity of coronary artery disease

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