Antitrichomonal and antioxidant activities of Dorstenia barteri and Dorstenia convexa

Omisore, N. O.; Adewunmi, C. O.; Iwalewa, E. O.; Ngadjui, Bonaventure T.; Adenowo, TK; Abegaz, Berhanu M.; Ojewole, John A. O.; Watchueng, Jean

doi:10.1590/s0100-879x2005000700012

Cited by 50 publications

(40 citation statements)

References 26 publications

(26 reference statements)

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“…In order to increase the reliability of the antioxidant results more than one protocols were used. However, in accordance with the criteria for evaluation of in vitro antioxidant activities of natural products [23,30,31], in this report we propose the following cutoff points;…”

Section: Resultsmentioning

confidence: 77%

“…The methanol extract of the flowering aerial parts of Echinops galalensis (Asteraceae), its fractions and the isolated compounds (25)(26)(27)(28)(29)(30)(31)(32)(33) have been reported for their hepatoprotective effects agaisnt CCl 4 induced cell damage in an in vitro assay on human hepatoma cell line (Huh7). The extract and isolated compounds (25)(26)(27)(28)(29)(30)(31)(32)(33) at 100 μg/mL prior to CCl 4 challenge protected against cell injury by decreasing the level of AST, ALT, MDA and increasing the activities of SOD [102].…”

Section: Echinops Galalensismentioning

confidence: 99%

“…The extract and isolated compounds (25)(26)(27)(28)(29)(30)(31)(32)(33) at 100 μg/mL prior to CCl 4 challenge protected against cell injury by decreasing the level of AST, ALT, MDA and increasing the activities of SOD [102]. The protective effects of E. galalensis methanolic extract, its fractions as well as the isolated compounds is at least partly due to their antioxidant activities as evidenced by the reduction in MDA level and the increase in SOD activity.…”

Section: Echinops Galalensismentioning

confidence: 99%

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African natural products with potential antioxidants and hepatoprotectives properties: a review

et al. 2016

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Free radicals are highly reactive molecules generated during oxidation reactions which in turn initiate chain reactions resulting to cellular damage. There is substantial evidence implicating free radicals especially reactive oxygen species (ROS) in the etiology of more than one hundred degenerative disorders in humans including, arthritis, atherosclerosis, ischemia and reperfusion injury of many tissues, gastritis, diabetics, central nervous system injury, acquired immunodeficiency syndrome (AIDS) and cancer. Scientific evidence postulates that bioactive compounds especially from natural products are capable of providing protection against free radicals. Consequently, few decades have witnessed a surfeit of research geared towards validating the antioxidant and hepatoprotective potential of the natural products. In this review, African natural products whose antioxidants activities were scientifically validated either in their crude extracts and/or derived products have been discussed. A total 1076 plants species representing 287 family, 132 isolated compounds and 7 insect/mollusk secreation were found. The plant species from the following families; Fababceae, Asteraceae, Lamiaceae, Moraceae, Euphorbiaceae, Combretaceae and Malvaceae have received more scientific attention than others. Analysis of the reports revealed that Combretum apiculatum, Telfaria occidentalis, Acalypha racemosa, Garcinia lucida were the most active plant extracts from African flora. The most active ROS-detoxifying phytochemicals were moracin T, U, S and R (84-87), oleanolic acid (54), 5,7,4′-trihydroxy-3,8,3′,5′-tetramethoxyflavone (89), 5,7,3′-trihydroxy-3,8,4′,5′-trimethoxyflavone (88), luteolin (3′,4′,5,7-tetrahydroxy flavone) (117) and genistein (4′,5,7-trihydroxyisoflavone) (116). The significant antioxidant potential demonstrated by some crude extracts and their constituent compounds render them good candidates for the development of new drugs. Although, the study of the mechanisms of actions as well as clinical validation of some of these isolated compounds is lacking. It is hoped that pertinent scientist and stakeholders will look further into some of these compounds for detailed authentification and subsequent commercialization.

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Section: Resultsmentioning

confidence: 77%

Section: Echinops Galalensismentioning

confidence: 99%

Section: Echinops Galalensismentioning

confidence: 99%

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African natural products with potential antioxidants and hepatoprotectives properties: a review

et al. 2016

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“…Due to their anti-inflammatory, antioxidant, and cytotoxic activities, it is supposed that the prenylflavonoids might be efficient on protecting plants from attacking insects. While several studies implied that the larvicidal activity may not mainly result from this kind of compound, Omisore et al (2005) studied several compounds extracted from Dorstenia barteri var. (Moraceae) and D. convexa against Trichomonas gallinarum, and the order of the anti-trichomonal activity at 24 h turned to be quercetin (0.121 mg/ml)4quercitrin (0.244 mg/ml) !…”

Section: Larvicidal Activitymentioning

confidence: 99%

A systematic review on biological activities of prenylated flavonoids

Chen

Mukwaya

Wong

et al. 2013

Pharmaceutical Biology

181

124

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Context: Prenylated flavonoids are a unique class of naturally occurring flavonoids that exist especially for the plant's self-defensive strategy. This special class of flavonoids increases the bioactivities of their backbone flavonoids with non-prenylation; therefore, prenylated flavonoids have more potential to be developed and utilized. Objective: The number, position and type of the prenyl group on the flavonoids backbone structure may have close relationships with the bioactivities of flavonoids. Methods: PubMed and WEB OF KNOWLEDGEÕ were used to search articles published in English between 1 January 2002 and 31 December 2012, which discuss the structure-activity relationship between prenylated flavonoids and their bioactivities. Results: It is proposed that the prenyl-moiety makes the backbone compound more lipophilic, which leads to its high affinity with cell membranes. The prenylation brings the flavonoids with enhancement of antibacterial, anti-inflammatory, antioxidant, cytotoxicity, larvicidal as well as estrogenic activities. However, it is reported that the prenyl-moiety decreases the bioavailability and plasma absorption of prenylated flavonoids. Conclusion: The prenyl group affects the bioactivities of flavonoids in certain ways, while the action mechanisms and the structure-activity relationship as well as more in vivo studies even clinical validation trials need to be further investigated.

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“…The molecular mechanism of chronic inflammation, its prevention and mitigation with phytomedicines have been intensively evaluated by our group over the past ten years (McGaw et al, 1997;Eloff et al, 2001;McGaw et al, 2001;Iwalewa et al, 2003;Omisore et al, 2004;Iwalewa and Agbani, 2004;Iwalewa et al, 2005;Omisore et al, 2005;Iwalewa et al, 2006;Idowu et al, 2006;Naidoo et al, 2006;Angeh et al, 2007). Epidemiological data suggest that lower incidences of certain chronic dis-*Corresponding author.…”

Section: Introductionmentioning

confidence: 99%

Inflammation: the foundation of diseases and disorders. A review of phytomedicines of South African origin used to treat pain and inflammatory conditions.

Iwalewa¹,

McGaw²,

Naidoo³

et al. 2007

Afr. J. Biotechnol.

152

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Great interest in herbal medicine as a potential source of phytopharmaceuticals has created the need to review common factors responsible for major diseases and body disorders. This review shows one such common factor in inflammation and the role herbal medicine can play. Traditional medicinal herbal remedies in the southern African region have long been used to treat various pain-or inflammation-related symptoms. Although the precise mechanisms of action of many herbal drugs have yet to be determined, some of them have been shown to exert anti-inflammatory and/or antioxidant effects in a variety of cells in the human and animal bodies. There is increasing evidence to indicate that both peripheral and central nervous system cells play a prominent role in the chronic inflammatory responses in the body system and anti-inflammatory herbal medicine and its constituents are being proved to be a potent protector against various pro-inflammatory mediators in diseases and disorders. These mediators have therefore been suspected of being the functional basis of diseases and disorders. The structural diversity of these medicinal herbs makes them a valuable source of novel lead compounds against the therapeutic molecular targets, cytokines and mediators, that have been newly discovered by the platforms of genomics, proteomics, metabolomics and highthroughput technologies. This article reviews the basic mechanisms of inflammation and the potential of 123 southern African plant species to be effective as chronic inflammatory disease preventive agents. With one third of these species there are no indications of the chemical composition, indicating possible subjects for further research.

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Antitrichomonal and antioxidant activities of Dorstenia barteri and Dorstenia convexa

Cited by 50 publications

References 26 publications

African natural products with potential antioxidants and hepatoprotectives properties: a review

African natural products with potential antioxidants and hepatoprotectives properties: a review

A systematic review on biological activities of prenylated flavonoids

Inflammation: the foundation of diseases and disorders. A review of phytomedicines of South African origin used to treat pain and inflammatory conditions.

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