Effect of D-alpha-tocopherol on tubular nephron acidification by rats with induced diabetes mellitus

Gomes, Guiomar Nascimento; Barbosa, Fernando Policarpo; Radaeli, R. F.; Cavanal, M. F.; Aires, Margarida de Mello; Gil, Frida Zaladek

doi:10.1590/s0100-879x2005000700007

Cited by 11 publications

(6 citation statements)

References 42 publications

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“…There are reports glomerular hypertrophy being inhibited through consumption of herbal antioxidants extracts such as garlic, ginger [ 38 ], and Ginkgo biloba [ 39 ] in diabetic animals. In addition, glomerular hypertrophy has been inhibited by antioxidants such as vitamin E and α-tochopherol in diabetic rats [ 40 , 41 ]. Anthocyanins are widely distributed in human diets, suggesting that we ingest large amounts of anthocyanins from plant-based foods.…”

Section: Discussionmentioning

confidence: 99%

Myrciaria cauliflora extracts attenuate diabetic nephropathy involving the Ras signaling pathway in streptozotocin/nicotinamide mice on a high fat diet

Hung

Shin

et al. 2016

Journal of Food and Drug Analysis

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Diabetic nephropathy (DN) is a major cause of end-stage renal disease and its mortality is continuously increasing worldwide. Previous studies indicate that reactive oxygen species play an important role in high glucose-induced renal injury. Myrciaria cauliflora has been reported as a functional food rich in anthocyanins possessing anti-oxidative and anti-inflammatory properties. This study examined whether M. cauliflora extracts (MCE) can attenuate diabetic nephropathy progression in type 2 diabetes mellitus mice. First, the composition of the anthocyanins and polyphenols of MCE were determined by high-performance liquid chromatography and spectrophotometry. One hundred mg/kg of streptozotocin and 240 mg/kg nicotinamide were administered to C57BL/6J mice fed a high fat diet and varied concentrations of MCE. The plasma glucose concentration, body weight, oral glucose tolerance, blood pressure, renal ultrasound ultrasonic wave were monitored every 2 weeks. Following euthanasia, the kidneys of the mice were analyzed using hematoxylin-eosin, periodic acid Schiff, Masson's trichrome, and immunohistochemistry staining. The results showed that MCE stabilized the plasma glucose and indirectly improved insulin sensitivity in diabetic mice. In addition, diabetes-caused glomerular atrophy, accumulation of saccharide, and formation of collagen IV were recovered or reduced under treatment with MCE in diabetic mice. Our results indicate that MCE has beneficial effects in DN and the mechanism has been confirmed to inhibit Ras/PI3K/Akt and kidney fibrosis related proteins. This work illustrates the potential of MCE rich in anthocyanins and polyphenols as a natural food to inhibit DN.

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Section: Discussionmentioning

confidence: 99%

Myrciaria cauliflora extracts attenuate diabetic nephropathy involving the Ras signaling pathway in streptozotocin/nicotinamide mice on a high fat diet

Hung

Shin

et al. 2016

Journal of Food and Drug Analysis

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“…[ 55 ] Studies in animal models have shown that antioxidant therapy has beneficial effects. [ 56,57 ] However, the results of antioxidant therapy in patients with DN are limited and partially conflicting. [ 15,17,32,58 ] Therefore, we collected data from 25 studies to evaluate the role of antioxidants in the treatment of DN.…”

Section: Discussionmentioning

confidence: 99%

Antioxidant for treatment of diabetic complications: A meta‐analysis and systematic review

Zhong

Wang

et al. 2022

J Biochem & Molecular Tox

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Antioxidants may provide a complementary treatment for patients with chronic diseases. Nevertheless, studies that have measured the effects of antioxidant on diabetes complications have provided conflicting results. This study aimed to elucidate the association between antioxidant and diabetic complications and to develop robust evidence for clinical decisions by systematic reviews and meta‐analysis. PubMed, Embase, The Cochrane Library, Web of Science, Scopus databases were searched to collect clinical studies related to the efficacy of antioxidants in the treatment of diabetes complications from inception to May 5, 2021. Statistical meta‐analyses were performed using the RevMan 5.4 software. Stata16 software was used to detect publication bias. The data of diabetic nephropathy (DN), diabetic nonalcoholic fatty liver disease (NAFLD), and diabetic periodontitis were collected to analyze the effect of antioxidant on diabetes and the above three complications. The meta‐analysis results showed that antioxidant treatment was associated with significantly changes in the fasting plasma glucose (FPG) (standardized mean difference [SMD]: − 0.21 [95% confidence interval [CI]: − 0.33, −0.10], p < 0.001), hemoglobin A1c (HbA1c) (MD: − 0.41 [95% CI: − 0.63, −0.18], p < 0.001), total antioxidant capacity (TAC) (SMD: 0.44 [95% CI: 0.24, 0.63], p < 0.001) and malondialdehyde (MDA) (SMD: − 0.82 [95% CI: − 1.24, −0.41], p < 0.001) than the control group. Antioxidant supplements have the potential to treat three complications of diabetes. In conclusion, the meta‐analysis results indicate that antioxidant treatment is effective clinically for diabetes mellitus and its complications.

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“…Hyperglycaemia increases reactive oxygen species (ROS) production and activates the RAS, which leads to further increases in ROS production. Previous studies using experimental diabetic models suggest positive effects of anti‐oxidant treatment on diabetic complications …”

Section: Introductionmentioning

confidence: 99%

Anti‐oxidative effect of the β‐blocker carvedilol on diabetic nephropathy in non‐obese type 2 diabetic rats

Yonekura

Fujii

Nakai

et al. 2015

Clin Exp Pharma Physio

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Oxidative stress plays an important role in the pathogenesis of diabetic nephropathy. The β-blocker carvedilol has been proven to have an anti-oxidant property. The aim of the present study was to elucidate the effects of carvedilol on diabetic nephropathy. At 20 weeks of age, male Spontaneously Diabetic Torii (SDT) rats were divided into three groups based on treatment: (i) an INS group (administered insulin); (ii) a CAR group (administered 10 mg/kg per day, p.o., carvedilol); and (iii) a diabetic (DM) group (administered vehicle). Rats were treated for a period of 10 weeks and were killed at 30 weeks of age. Urinary albumin excretion, renal histomorphology, and oxidative stress were evaluated. Urinary albumin excretion was significantly lower in the CAR than DM group (42.82 ± 3.94 vs 76.62 ± 13.74 mg/day respectively; P < 0.05). The mesangial index was lower in the CAR group than in the DM group. Urinary excretion of 8-hydroxydeoxyguanosine (8-OHdG), the number of 8-OHdG-positive cells in glomeruli, and the mRNA expression of NADPH oxidase p22 and p47 were also lower in the CAR than DM group. However, haemoglobin A1c (HbA1c) and blood pressure levels were comparable between the two groups. The results suggest that carvedilol could prevent the progression of diabetic nephropathy by suppressing oxidative stress.

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Effect of D-alpha-tocopherol on tubular nephron acidification by rats with induced diabetes mellitus

Cited by 11 publications

References 42 publications

Myrciaria cauliflora extracts attenuate diabetic nephropathy involving the Ras signaling pathway in streptozotocin/nicotinamide mice on a high fat diet

Myrciaria cauliflora extracts attenuate diabetic nephropathy involving the Ras signaling pathway in streptozotocin/nicotinamide mice on a high fat diet

Antioxidant for treatment of diabetic complications: A meta‐analysis and systematic review

Anti‐oxidative effect of the β‐blocker carvedilol on diabetic nephropathy in non‐obese type 2 diabetic rats

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