The importance of accurate anatomic assessment for the volumetric analysis of the amygdala

Bonilha, Leonardo; Kobayashi, Eliane; Cendes, Fernando; Li, L.M.

doi:10.1590/s0100-879x2005000300012

Cited by 12 publications

(7 citation statements)

References 32 publications

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“…Volume values obtained by MRI with a section thickness of one mm and threedimensional analysis should be preferred. Such results are similar to those of post-mortem studies [25].…”

Section: Discussionsupporting

confidence: 91%

A comparative evaluation of bilateral hippocampus and amygdala volumes with ADC values in pediatric primary idiopathic partial epilepsy patients

Taskent¹,

Danışan²,

Yıldırım³

2019

Journal of Surgery and Medicine

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“…Volume values obtained by MRI with a section thickness of one mm and threedimensional analysis should be preferred. Such results are similar to those of post-mortem studies [25].…”

Section: Discussionsupporting

confidence: 91%

A comparative evaluation of bilateral hippocampus and amygdala volumes with ADC values in pediatric primary idiopathic partial epilepsy patients

Taskent¹,

Danışan²,

Yıldırım³

2019

Journal of Surgery and Medicine

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“…Coronal T1-IR (3 mm thick, flip angle 120˚, repetition time 6800 ms, echo time 129 ms, matrix 2526328, field of view 21623 cm) images were analysed using anatomical guidelines obtained from a standardised protocol 33 for manual segmentations of hippocampal and total brain volumes (fig 1). Quantification and analysis were carried out by one investigator (ADC) blind to the patients' clinical data.…”

Section: Mri Acquisitionmentioning

confidence: 99%

Hippocampal atrophy in systemic lupus erythematosus

Appenzeller

Carnevalle²,

Li³

et al. 2006

Annals of the Rheumatic Diseases

103

107

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Objectives: To determine the frequency and progression of hippocampal atrophy in systemic lupus erythematosus (SLE) and the clinical, laboratory and treatment features associated with its occurrence. Methods: 150 patients with SLE and 40 healthy volunteers were enrolled in our study. A complete clinical, laboratory and neurological evaluation was performed. Magnetic resonance imaging was carried out using a 2T scanner (Elscint Prestige) and coronal T1-weighted images were used for manual volumetric measurements. Atrophy was defined as values ,2 standard deviations from the means of controls. Results: At entry into the study, the mean right and left hippocampal volumes of patients were significantly smaller than the hippocampal volumes of controls (p,0.001). After the follow-up magnetic resonance imaging, a significant progression of reduction in right and left hippocampal volumes in patients was observed (p,0.001). At entry, atrophy was identified in 43.9% and at follow-up in 66.7% of patients with SLE. Hippocampal atrophy was related to disease duration (p,0.001) total corticosteroid dose (p = 0.01) and history of central nervous system (CNS) manifestations (p = 0.01). Progression of atrophy was associated with cumulative corticosteroid dose (p = 0.01) and number of CNS events (p = 0.01). Patients with cognitive impairment had more severe hippocampal atrophy than those without. Conclusion: Disease duration, total corticosteroid dose and greater number of CNS manifestations were associated with hippocampal atrophy in patients with SLE. A significant progression of hippocampal atrophy related to total corticosteroid dose and number of CNS events was observed. Further studies are necessary to confirm these findings.

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“…Anatomical guidelines for outlining the hippocampus followed a specific protocol previously described. 6,31 Once the outline had been defined, the slice area was calculated automatically by the computer program. We then calculated the total volumes (mm 3 ) as the sum of each area multiplied by the slice thickness.…”

Section: Hippocampi Volumesmentioning

confidence: 99%

Abnormality in hippocampal signal intensity predicts atrophy in patients with systemic lupus erythematosus

Lapa

Pedro

Francischinelli

et al. 2016

Lupus

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Objectives To quantify signal abnormalities in the hippocampus (Hsig) of patients with systemic lupus erythematosus (SLE) and to determine if Hsig predict hippocampal atrophy (HA) in SLE. Methods We included all SLE patients and healthy age- and sex-matched individuals with two magnetic resonance imaging (MRI) scans performed with a minimum of 1 year interval. All individuals underwent a standardized neuropsychological evaluation. Individual results were converted into standard scores and compared to normative data. SLE patients were additionally assessed for disease activity (SLE Disease Activity Index (SLEDAI)), damage (Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (SDI)), and the presence of antiphospholipid antibodies. MRI was performed on an Elscint 2 T scanner and T1 inversion recovery and T2 coronal images were used for analysis. Volumetric (HV) and signal quantification (Hsig) were determined by standardized protocols. Results We included 54 SLE patients (48 women; mean age 32.2 ± 10.56 years). Hsig were found at study entry in 15 (45.5%) patients. Hsig in the body and tail of non-atrophic hippocampi correlated with progression of volume loss during the follow-up period ( r = 0.8, p < 0.001). The presence of Hsig in the head of atrophic hippocampi correlated with progression of HA ( r = 0.73, p = 0.005) during the same period. No correlation of Hsig and disease activity or prednisone dose was observed. Conclusion HA is frequently observed in SLE patients and volume loss is progressive in a subgroup of patients. The evaluation of Hsig is an easy tool to determine patients that may have progressive hippocampal volume loss and should be followed more closely with MRI and cognitive evaluation.

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The importance of accurate anatomic assessment for the volumetric analysis of the amygdala

Cited by 12 publications

References 32 publications

A comparative evaluation of bilateral hippocampus and amygdala volumes with ADC values in pediatric primary idiopathic partial epilepsy patients

A comparative evaluation of bilateral hippocampus and amygdala volumes with ADC values in pediatric primary idiopathic partial epilepsy patients

Hippocampal atrophy in systemic lupus erythematosus

Abnormality in hippocampal signal intensity predicts atrophy in patients with systemic lupus erythematosus

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