Antagonism of the acute hemodynamic effects of captopril in decompensated congestive heart failure by aspirin administration

Viecili, Paulo Ricardo Nazário; Pamplona, Daneiel Alberto; Park, M.; Silva, S.R.; Ramires, José Antônio Franchini; Luz, Protásio Lemos da

doi:10.1590/s0100-879x2003000600013

Cited by 4 publications

(3 citation statements)

References 27 publications

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“…Hence, the multi-dose pharmacokinetic model should be established. Also, Viecili [25] reported that captopril alone produced an increase in cardiac index and a decrease in systemic vascular resistance and pulmonary capillary wedge pressure. In the future, pressure of pulmonary can be considered for captopril.…”

Section: Discussionmentioning

confidence: 99%

The effect of captopril on the performance of the control strategies of BJUT-II VAD

Gao

Chang

et al. 2016

BioMed Eng OnLine

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BackgroundWith the development of left ventricular assist device (LVAD), the long-term support has been paid more attention by various researchers. According to previous researches, the combination of LVAD and pharmacological therapy can significantly improve the heart rate recovery and survival rate of patient. However, the effect of pharmacological therapy on the cardiovascular hemodynamic states with LVAD support is still unclear.MethodsIn this study, pharmacokinetic model of captopril is established to describe the relationship between plasma–drug concentration and time. Then, combination model, consisting of pharmacokinetic model of captopril and lumped parameter model of cardiovascular system with BJUT-II VAD support, is established to mimic the effect of pharmacological therapy on cardiovascular hemodynamics. BAI control strategy and HR control strategy for BJUT-II VAD are chosen to evaluate their performance by the combination model.ResultsThe simulation results demonstrate that the concentration of captopril could affect the pressure and heart rate by changing the peripheral resistance, and then affect the performance of BJUT-II VAD in a short duration. Under the regulation of control strategies of BJUT-II VAD, the hemodynamic states of cardiovascular system returned to the standard value in 10 s.ConclusionThis study could provide useful information about how to design coupled strategy of LVAD support and pharmacological therapy.

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Section: Discussionmentioning

confidence: 99%

The effect of captopril on the performance of the control strategies of BJUT-II VAD

Gao

Chang

et al. 2016

BioMed Eng OnLine

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“…The high systemic vascular resistance occurred despite the fact that the patients were taking a high dose of an ACE inhibitor (captopril: 134 mg/d). In fact, Parker et al observed a reduction in systemic vascular resistance in patients with severe heart failure who were taking ACE inhibitors; however, this resistance remained above the normal values (21,22). The cardiac index was normal; however, all patients were using intravenous inotrope.…”

Section: Hemodynamic Condition During Heart Failure Decompensationmentioning

confidence: 97%

Short-Term Add-On Therapy With Angiotensin Receptor Blocker for End-Stage Inotrope-Dependent Heart Failure Patients: B-Type Natriuretic Peptide Reduction in a Randomized Clinical Trial

Ochiai

Brancalhao

Puig

et al. 2012

Journal of Cardiac Failure

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OBJECTIVE:We aimed to evaluate angiotensin receptor blocker add-on therapy in patients with low cardiac output during decompensated heart failure. METHODS: We selected patients with decompensated heart failure, low cardiac output, dobutamine dependence, and an ejection fraction ,0.45 who were receiving an angiotensin-converting enzyme inhibitor. The patients were randomized to losartan or placebo and underwent invasive hemodynamic and B-type natriuretic peptide measurements at baseline and on the seventh day after intervention. ClinicalTrials.gov: NCT01857999. RESULTS: We studied 10 patients in the losartan group and 11 patients in the placebo group. The patient characteristics were as follows: age 52.7 years, ejection fraction 21.3%, dobutamine infusion 8.5 mcg/kg.min, indexed systemic vascular resistance 1918.0 dynes.sec/cm 5 .m 2 , cardiac index 2.8 L/min.m 2 , and B-type natriuretic peptide 1,403 pg/mL. After 7 days of intervention, there was a 37.4% reduction in the B-type natriuretic peptide levels in the losartan group compared with an 11.9% increase in the placebo group (mean difference, -49.1%; 95% confidence interval: -88.1 to -9.8%, p = 0.018). No significant difference was observed in the hemodynamic measurements. CONCLUSION: Short-term add-on therapy with losartan reduced B-type natriuretic peptide levels in patients hospitalized for decompensated severe heart failure and low cardiac output with inotrope dependence.

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“…26 Then when two drugs are combined, such as diuretics with calcium channel blockers, or aspirin with ACE inhibitors, the detrimental effects can even be compounded. 27,28 Although such observations have been gleaned fairly from the literature, they could easily be critiqued or dismissed by citing other studies. The point that should not be missed, however, is that the pros/cons of various drugs are always going to be debatable, as each new drug jockeys for a favored position in medicine's therapeutic armamentarium.…”

Section: The Hidden Costmentioning

confidence: 99%

Drugs And Acupuncture: The Energetic Impact of Antihypertensives

Greenwood¹

2007

Medical Acupuncture

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The issue of a patient's medications can be a matter of prime concern to medical acupuncturists. In this article, I use adverse effect profiles and pulse changes to explore the energetic effects of various antihypertensives and suggest that the intentional vector behind drug treatment for hypertension may be in direct opposition to that of acupuncture. Herein, I explore this issue and discuss four commonly used classes of drugs: ␤-blockers, angiotensin-converting enzyme inhibitors, calcium channel blockers, and diuretics.

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Antagonism of the acute hemodynamic effects of captopril in decompensated congestive heart failure by aspirin administration

Abstract: The concomitant use of angiotensin

Cited by 4 publications

References 27 publications

The effect of captopril on the performance of the control strategies of BJUT-II VAD

The effect of captopril on the performance of the control strategies of BJUT-II VAD

Short-Term Add-On Therapy With Angiotensin Receptor Blocker for End-Stage Inotrope-Dependent Heart Failure Patients: B-Type Natriuretic Peptide Reduction in a Randomized Clinical Trial

Drugs And Acupuncture: The Energetic Impact of Antihypertensives

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