The effect of captopril on the performance of the control strategies of BJUT-II VAD

Abstract

BackgroundWith the development of left ventricular assist device (LVAD), the long-term support has been paid more attention by various researchers. According to previous researches, the combination of LVAD and pharmacological therapy can significantly improve the heart rate recovery and survival rate of patient. However, the effect of pharmacological therapy on the cardiovascular hemodynamic states with LVAD support is still unclear.MethodsIn this study, pharmacokinetic model of captopril is established to describe the relationship between plasma–drug concentration and time. Then, combination model, consisting of pharmacokinetic model of captopril and lumped parameter model of cardiovascular system with BJUT-II VAD support, is established to mimic the effect of pharmacological therapy on cardiovascular hemodynamics. BAI control strategy and HR control strategy for BJUT-II VAD are chosen to evaluate their performance by the combination model.ResultsThe simulation results demonstrate that the concentration of captopril could affect the pressure and heart rate by changing the peripheral resistance, and then affect the performance of BJUT-II VAD in a short duration. Under the regulation of control strategies of BJUT-II VAD, the hemodynamic states of cardiovascular system returned to the standard value in 10 s.ConclusionThis study could provide useful information about how to design coupled strategy of LVAD support and pharmacological therapy.

Preface: Computational and experimental methods for biological research: cardiovascular diseases and beyond

“…Gu et al [21] studied the effect of captopril on the performance of the control strategies of BJUT-II VAD. Zhang et al [19] provided an optimization study of patient-specific design of flow diverters made from helix-like wires.…”