Intestinal permeability in strongyloidiasis

Werneck-Silva, Ana Luiza; Sipahi, Aytan Miranda; Damião, Adérson Omar Mourão Cintra; Buchpigue, C.A.; Iriya, K; Laudanna, Antônio Atílio

doi:10.1590/s0100-879x2001000300009

Cited by 14 publications

(7 citation statements)

References 32 publications

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“…In this study, the intestinal permeability test was also undertaken in 11 healthy controls, and our results were similar with other Brazilian studies but greater than those in European studies [39,40]. After statistical treatment using the Student-Newman-Keuls test it was observed that urinary lactulose excretion showed different patterns in the three subgroups, and the same occurred with the lactulose/mannitol ratio, confirming that there was no complete normalization in the values of the negative AGA subgroup.…”

Section: Discussionsupporting

confidence: 89%

Intestinal Permeability and Antigliadin Antibody Test for Monitoring Adult Patients with Celiac Disease

et al. 2007

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Celiac disease causes chronic inflammation of the intestinal mucosa and reduces surface absorption; after the withdrawal of gluten from the diet, there are clinical and histologic improvements. The intestinal permeability test and serologic tests are useful for confirming the diagnosis and monitoring patients. The goal of this study is to compare the antigliadin antibody (AGA) test with the intestinal permeability test for celiac patients on a gluten-free diet. The sample consisted of 22 celiac patients who were antigliadin immunoglobulin A-positive before treatment. After 12 months on a gluten-free diet, AGA testing was repeated and the intestinal permeability test was performed. A control group was composed of 11 healthy individuals. AGA remained positive in 40.9% of celiac patients, and the mean urinary lactulose excretion was 10.27%, that of mannitol was 10.18%, and the lactulose/mannitol ratio was 1.02. In the subgroup in which antigliadin became negative (59.1%), the value for lactulose was 3.79%, that for mannitol was 11.12%, the lactulose/mannitol ratio was 0.38, and the p value was less than 0.0001, 0.66, and less than 0.0001, respectively. When the two celiac subgroups were compared with the control group, the urinary lactulose excretion and the lactulose/mannitol ratio was less in the control group, whereas urinary mannitol excretion was greater. The p values were less than 0.0001 for the three variables, suggesting persistent lesions in mucosa of both subgroups, although to a lesser degree for those that became AGA negative. It is concluded that intestinal permeability allows a more precise clinical physiopathologic correlation than antigliadin and offers more information for the monitoring of these patients.

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Section: Discussionsupporting

confidence: 89%

Intestinal Permeability and Antigliadin Antibody Test for Monitoring Adult Patients with Celiac Disease

et al. 2007

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“…Relevantly, decreased serum acetate level was also observed in strongyloidiasis in an endemic area 14 . Contradictory findings of acetate level between serum and fecal samples may be due to a variety of other factors related to SCFA production, not only S. stercoralis infection 16,[35][36][37] . In addition, Bacteroidaceae also harbors several mucin-degrading groups and several of the glycosyl hydrolases identified in Supplementary Table S4 degrade dietary components as well as mucin glycans 38,39 .…”

Section: Discussionmentioning

confidence: 99%

Chronic Strongyloides stercoralis infection increases presence of the Ruminococcus torques group in the gut and alters the microbial proteome

Tran

Chaidee

Surapinit

et al. 2023

Sci Rep

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We explored the impact of chronic Strongyloides stercoralis infection on the gut microbiome and microbial activity in a longitudinal study. At baseline (time-point T0), 42 fecal samples from matched individuals (21 positive for strongyloidiasis and 21 negative) were subjected to microbiome 16S-rRNA sequencing. Those positive at T0 (untreated then because of COVID19 lockdowns) were retested one year later (T1). Persistent infection in these individuals indicated chronic strongyloidiasis: they were treated with ivermectin and retested four months later (T2). Fecal samples at T1 and T2 were subjected to 16S-rRNA sequencing and LC–MS/MS to determine microbial diversity and proteomes. No significant alteration of indices of gut microbial diversity was found in chronic strongyloidiasis. However, the Ruminococcus torques group was highly over-represented in chronic infection. Metaproteome data revealed enrichment of Ruminococcus torques mucin-degrader enzymes in infection, possibly influencing the ability of the host to expel parasites. Metaproteomics indicated an increase in carbohydrate metabolism and Bacteroidaceae accounted for this change in chronic infection. STITCH interaction networks explored highly expressed microbial proteins before treatment and short-chain fatty acids involved in the synthesis of acetate. In conclusion, our data indicate that chronic S. stercoralis infection increases Ruminococcus torques group and alters the microbial proteome.

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“…This pig whipworm induces a less intense and persistent inflammatory response, although Williams et al[ 56 ] verified that T. suis can mature to adult size and reproduce in humans. That is why we see S. stercoralis as a more potentially useful nematode, as it has proven to significantly diminish the intestinal permeability in humans[ 23 ], altering the interleukin profile in a more systemic way[ 42 ]. The prolonged interaction between S. stercoralis and its host induces a greater immunomodulatory action.…”

Section: Discussionmentioning

confidence: 99%

“…When urinary clearance of 51 Cr-EDTA is decreased, this indicates decreased intestinal permeability. Werneck-Silva et al[ 23 ] demonstrated that infection with Strongyloides stercoralis can diminish intestinal permeability compared to healthy volunteers ( P = 0.0001). Intestinal infection with S. stercoralis led to abnormalities in mucus secretion and intestinal motility, as well as possible loss of macromolecules.…”

Section: Introductionmentioning

confidence: 99%

Helminths as an alternative therapy for intestinal diseases

Sipahi

Baptista

2017

WJG

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Animal models and clinical studies have shown that helminth infections exert immunomodulatory activity, altering intestinal permeability and providing a potential beneficial action on autoimmune and inflammatory disorders in human beings, such as inflammatory bowel disease (IBD) and celiac disease. This is consistent with the theory that intestinal microbiota is responsible for shaping human immunological responses. With the arrival of the immunobiologic era and the use of antibodies, we propose a distinctive pathway for treating patients with IBD and celiac disease. We have some evidence about the safety and tolerability of helminth use, but evidence about their impact on disease activity is lacking. Using worms to treat diseases could be a possible way to lower treatment costs, since the era of immunobiologic agents is responsible for a significant rise in expenses. Some questions remain to be investigated regarding the use of helminths in intestinal disease, such as the importance of the specific species of helminths used, appropriate dosing regimens, optimal timing of treatment, the role of host genetics, diet, environment, and the elucidation of the exact mechanisms of action. One promising approach is the use of helminth-derived anti-inflammatory molecules as drugs. Yet there are still many challenges with this method, especially with regard to safety. Studies on intestinal permeability point to Strongyloides stercoralis as a useful nematode for these purposes.

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Intestinal permeability in strongyloidiasis

Cited by 14 publications

References 32 publications

Intestinal Permeability and Antigliadin Antibody Test for Monitoring Adult Patients with Celiac Disease

Intestinal Permeability and Antigliadin Antibody Test for Monitoring Adult Patients with Celiac Disease

Chronic Strongyloides stercoralis infection increases presence of the Ruminococcus torques group in the gut and alters the microbial proteome

Helminths as an alternative therapy for intestinal diseases

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