Serum cytokines in patients with Brazilian pemphigus foliaceus (fogo selvagem)

Zeoti, D. M.; Figueiredo, José Fernando de Castro; Chiossi, Maria Paula do Valle; Roselino, Ana Maria Ferreira

doi:10.1590/s0100-879x2000000900012

Cited by 19 publications

(17 citation statements)

References 12 publications

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“…Interestingly, many other GC alterations can be reversible in culture but sustained with cytokine co-incubation, suggesting that cytokine secretion may contribute to the acquired GR defect found in asthma steroid resistant [23]. In addition, while pemphigus is an antibody mediated disease, the role of T cells in its pathogenesis is being increasingly recognized [14,42]. Therefore, increased production of cytokines can be associated not only with pemphigus pathogenesis but also can represent another possible mechanism of GC resistance in pemphigus.…”

Section: Discussionmentioning

confidence: 99%

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Glucocorticoid Sensitivity and Proinflammatory Cytokines Pattern in Pemphigus

2012

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Glucocorticoids (GC) represent the main treatment for pemphigus; however, some patients show GC resistance. GC sensitivity was evaluated in 19 pemphigus patients and 41 controls by the number of binding sites [B max (fmol/mg protein)] and the affinity of GC receptor [Kd (nM)] to dexamethasone (DEX) as well as by the pattern of cytokine by DEXmediated inhibition of concanavalin-A (Con-A)-stimulated PBMC proliferation. The Kd (15.7±2.8 vs.8.1±1.3) and Bmax (6.5±0.9 vs. 3.9±0.3) were higher in pemphigus than controls (p00.002). Considering the values above the 95th percentile of normal group as a cut-off (K d >24.9 nM and B max >8.1 fmol/mg protein), elevated K d and B max were observed in 9.8% and 2.4% of controls and 15.8% and 36.8% of patients (p00.02). PBMC proliferation was stimulated by Con-A and inhibited by DEX (p<0.001) in both pemphigus and control groups. IL-6 and TNFα (pg/mL) basal production were higher in patients than controls. There was an increment of these cytokines after Con-A stimulation, and they were inhibited by DEX (p00.002) in controls and remained elevated in pemphigus (p<0.02). Patients and controls showed no difference in basal and stimulated production of IL-8 and IL-10. There is an alteration on GC sensitivity in pemphigus patients and a higher production of proinflammatory cytokines. Therefore, in pemphigus patients, proinflammatory cytokines might be involved in the mechanism of GC resistance and/or in its maintenance.

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Section: Discussionmentioning

confidence: 99%

“…Few studies have been undertaken to measure serum cytokine levels in patients with pemphigus [14,42,43]. In these studies, while IL-6 and TNF-α levels were increased, low to undetectable levels of IL-8 and IFN-γ were found in serum of pemphigus patients.…”

Section: Discussionmentioning

confidence: 99%

Glucocorticoid Sensitivity and Proinflammatory Cytokines Pattern in Pemphigus

2012

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“…It was demonstrated that after treatment, IL-4 level decreased in both mild and server patients [50]. In contrast, Zeoti et al [51] detected lower IL-4 in PF patients as compared to the controls. In addition to IL-4 level in serum, the presence of high level of IL-4 was also confirmed in perilesional skin biopsies [52].…”

Section: Il-4 Cytokine Level In Pv and Pf Patientsmentioning

confidence: 99%

Interleukin 4 inhibition as a potential therapeutic in pemphigus

Tavakolpour

2016

Cytokine

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“…3 - 5 Our research group has studied certain aspects of pemphigus pathogenesis which environmental factors allied to genetic predisposition need to be determined. 6 - 10 Treatment consists mainly of systemic corticosteroids, administered orally or by venous pulse therapy, associated, or not, with cyclophosphamide. 11,12 Due to the introduction of rituximab, it is now possible to avoid corticosteroids and minimize their side effects.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Metabolic Syndrome and its components in a Brazilian sample of pemphigus patients

Ambiel

Roselino

2014

An. Bras. Dermatol.

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BACKGROUNDPemphigus foliaceus and pemphigus vulgaris are endemic in the northeastern region of São Paulo State, Brazil. They are treated mainly with systemic corticosteroids, which may provoke osteoporosis; atherosclerosis, higher blood pressure, insulin resistance, glucose intolerance, hyperlipidemia and abdominal obesity. These side effects of corticoids also constitute criteria for the diagnosis of metabolic syndrome.OBJECTIVEThe prevalence of metabolic syndrome and each component of metabolic syndrome in Pemphigus foliaceus and pemphigus vulgaris groups was compared with Brazilian casuistic samples.METHODSData of 147 patients (pemphigus foliaceus 48.9% and pemphigus vulgaris 51.1%) were compiled from medical records regarding metabolic syndrome and its components, and included in the analysis.RESULTSThere was no significant difference regarding the prevalence of metabolic syndrome in pemphigus groups compared with the Brazilian casuistic samples. The analysis of each component of metabolic syndrome showed a higher prevalence of: higher blood pressure in male subjects with pemphigus vulgaris, and in pemphigus foliaceus in both genders; diabetes mellitus in both genders for pemphigus vulgaris and pemphigus foliaceus; obesity in females for pemphigus vulgaris and pemphigus foliaceus, and hypertriglyceridemia in both genders for pemphigus vulgaris and pemphigus foliaceus groups that were statistically significant compared to the Brazilian reports. Furthermore, the study noted a higher incidence of cardiovascular events in both genders in pemphigus foliaceus and pemphigus vulgaris groups than in Brazilian casuistic samples.CONCLUSIONThe components of metabolic syndrome are more numerous in pemphigus when compared with Brazilian casuistic samples. Future studies are necessary to assure that metabolic syndrome may be associated with pemphigus per se, including a greater casuistic sample of patients who have not taken corticoids.

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Serum cytokines in patients with Brazilian pemphigus foliaceus (fogo selvagem)

Cited by 19 publications

References 12 publications

Glucocorticoid Sensitivity and Proinflammatory Cytokines Pattern in Pemphigus

Glucocorticoid Sensitivity and Proinflammatory Cytokines Pattern in Pemphigus

Interleukin 4 inhibition as a potential therapeutic in pemphigus

Prevalence of Metabolic Syndrome and its components in a Brazilian sample of pemphigus patients

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