Inhibition of rat microsomal lipid peroxidation by the oral administration of D002

Menéndez, Roberto; Amor, Ana María; González, Ricardo; Jiménez, Sònia; Más, Rosa

doi:10.1590/s0100-879x2000000100012

Cited by 27 publications

(31 citation statements)

References 18 publications

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“…Oral treatment with D-002, however, is gastroprotective, rather than gastrotoxic, through a mechanism that involves increased secretion and improved composition of the gastric mucus, and reduced lipid peroxidation in the gastric mucosa [14][15][16]. Antioxidant effects of D-002 have been demonstrated in experimental and clinical studies [21][22][23][24][25][26][27]. Keeping in mind this background, we believed that D-002 could improve OA symptoms.…”

Section: Introductionmentioning

confidence: 99%

Effects of D-002, a mixture of beeswax alcohols, on osteoarthritis symptoms: a randomized placebo-controlled study

Rodríguez¹

2012

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Section: Introductionmentioning

confidence: 99%

Effects of D-002, a mixture of beeswax alcohols, on osteoarthritis symptoms: a randomized placebo-controlled study

Rodríguez¹

2012

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“…Prevention of LDL oxidation was shown to be one of SCP cardioprotective properties. Animal (Menendez et al, 1999b;Menendez et al, 2000b) and human studies (Menendez et al, 2000b;Castano et al, 2002c) show decreased lipid peroxidation as a result of SCP treatment. In rabbits with exogenous hypercholesterolemia, policosanols had a dose-dependant protective effect on atherosclerotic lesions, as 25 and 200 mg/kg/day of SCP resulted in significantly less aortic fatty streaks with foam cells of macrophage origin (Arruzazabala et al, 1994).…”

Section: Effect Of Policosanols On Cholesterol Metabolismmentioning

confidence: 96%

“…Bridge 4 In addition to their cholesterol lowering action, SCP are thought to possess antioxidant properties (Menendez et al, 2000b;Castano et al, 2002c). LDL-oxidation is now known to be a major triggering step in the atherosclerotic process (Williams & Tabas, 1995), placing antioxidant agents at the forefront of natural health products for the prevention of cardiovascular diseases .…”

Section: Acknowledgementsmentioning

confidence: 99%

“…LDL-oxidation is now known to be a major triggering step in the atherosclerotic process (Williams & Tabas, 1995), placing antioxidant agents at the forefront of natural health products for the prevention of cardiovascular diseases . Extensive animal and human evidence originating from Cuba indicates reductions in conjugated diene production of up to 38% in human LDL as a result of treatment with SCP (Menendez et al, 1999b;Menendez et al, 2000b;Menendez et al, 2000c). On the other hand, the only independent study that has looked at the antioxidant power of SCP refuted antioxidant claims, reporting no changes in LDL oxidation in response to SCP (Ng et al, 2005).…”

Section: Acknowledgementsmentioning

confidence: 99%

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Evaluation of cholesterol-lowering and antioxidant properties of sugar cane policosanols in hamsters and humans

Kassis

2008

Appl. Physiol. Nutr. Metab.

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Atherosclerosis prevention is now a major focus of the scientific community and the pharmaceutical industry. Sugar cane policosanols (SCP) have gained increasing popularity over the last decade as a result of numerous studies conducted in Cuba considering SCP as the natural alternative to statin drugs. However, independent research on policosanols was not able to replicate cholesterol reductions reported by Cuban laboratories. No independent study to date has examined the cholesterol-lowering effect and antioxidant capacity of original SCP in humans. In addition, since independent research was criticized because of the use of alternative policosanol formulations, the source and composition of policosanol mixtures are now at the core of the policosanol controversy.The aim of the present thesis project was first to compare the composition and cholesterol-lowering effects of different SCP preparations in hamsters, and secondly to test the cholesterol-lowering efficacy, mechanism of action and antioxidant capacity of the original Cuban SCP in hypercholesterolemic humans.Study 1: Forty-eight male hamsters were randomly assigned to 4 groups for a period of 4 weeks (i) non-cholesterol control, (ii) cholesterol control, (iii) original SCP and (iv) alternative SCP. Hamsters were sacrificed and blood was collected at the end of the feeding period for lipid measurements.Study 2: Twenty-one hypercholesterolemic volunteers consumed 10 mg/day of SCP or a placebo for a period of 28 days in a crossover trial. Plasma lipid levels and LDL oxidation were measured at the start and end of supplementation phases. Cholesterol absorption and synthesis were assessed using single isotope single tracer technique and deuterium incorporation respectively.There was no significant difference in cholesterol-lowering efficacy between hamsters in the original and alternative SCP groups relative to control. Similarly, in hypercholesterolemic humans, original SCP supplementation did not significantly improve lipid parameters and no change in cholesterol absorption or synthesis was observed relative to control. In vivo assessment of LDL oxidation showed no significant changes in oxidized LDL concentration relative to baseline and control.

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“…Estudios experimentales y clínicos han demostrado que el D-002 presenta efectos antiinflamatorios, antioxidantes y gastroprotectores (10)(11)(12)(13)(14)(15)(16)(17) .…”

Section: Introductionunclassified

Efectos en ratas de los alcoholes de cera de abejas (D-002) sobre la colitis ulcerativa inducida por sulfato de dextrano y etanol

Molina-Cuevas

Ravelo-Calzado

Zamora-Rodríguez

et al. 2017

Rev Peru Med Exp Salud Publica

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RESUMENObjetivos. Investigar los efectos del D-002, mezcla de seis alcoholes alifáticos primarios de alto peso molecular, obtenida de la cera de abejas (Apis mellifera), sobre la colitis ulcerativa (CU) inflamatoria severa inducida por sulfato de dextrano (DSS) y etanol en ratas (Ratus ratus). Materiales y métodos. Las ratas se distribuyeron aleatoriamente en seis grupos: un control cero al que no se provocó daño, y cinco a los que se les indujo la CU: un control negativo (vehículo), tres tratados con D-002 (25, 100 y 400 mg/kg) y un control positivo con sulfazalacina (200 mg/kg) (sustancia de referencia). Se cuantificaron las manifestaciones clínicas (variación del peso corporal, presencia de diarrea y de sangrado rectal), el puntaje de daño macroscópico e histológico, y la actividad de mieoloperoxidasa (MPO). Resultados. El tratamiento oral con D-002 (25, 100 y 400 mg/kg) previno significativamente la disminución del peso corporal. La dosis de 400 mg/kg redujo la presencia de diarreas y sangrado rectal, aunque su comparación con el control negativo solo alcanzó significación estadística sobre las diarreas. El D-002 (25, 100 y 400 mg/kg) redujo significativamente el puntaje de las lesiones macroscópicas (40,0; 43,3 y 47,2% de inhibición, respectivamente), el puntaje de daño histológico (31,5; 53,7 y 67,1% de inhibición, respectivamente) y la actividad de MPO (73,2; 83,6 y 85,0% de inhibición, respectivamente), comparado con el grupo control negativo. La sulfazalacina redujo significativamente todas las variables estudiadas. Conclusiones. El D-002 (25, 100 y 400 mg/kg) protegió significativamente la mucosa colónica en ratas con CU inflamatoria severa inducida por DSS y etanol. Palabras clave: Abejas; Colitis ulcerosa; Ratas (Fuente: DeCS BIREME). EFFECTS IN RATS OF BEE-WAX ALCOHOLS (D-002) ON ULCERATIVE COLITIS INDUCED BY DEXTRAN SULFATE AND ETHANOL ABSTRACTObjectives. To investigate the effects of D-002, a mixture of 6 high molecular weight primary aliphatic alcohols, obtained from beeswax (Apis mellifera), on severe inflammatory ulcerative colitis (UC) induced by Dextran sulfate (DSS) and ethanol in rats (Ratus ratus). Materials and methods. Rats were randomly distributed in six groups: a zero control to which no damage was caused, and five to which the UC was induced: a negative control (vehicle), three treated with D-002 (25, 100 and 400 mg/kg) and a positive control with sulfasalazine (200 mg/kg) (reference substance). Clinical manifestations (body weight variation, diarrhea and rectal bleeding), macroscopic and histological damage score, and myeloperoxidase (MPO) activity were quantified. Results. The oral treatment with D-002 (25, 100 and 400 mg/ kg) significantly prevented the decrease in body weight. The dose of 400 mg/kg reduced the presence of diarrhea and rectal bleeding, although its comparison with the negative control only reached statistical significance on diarrhea. D-002 (25, 100 and 400 mg/kg) significantly reduced the score of macroscopic lesions (40.0; 43.3 and 47.2% inhibition, respectively...

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Inhibition of rat microsomal lipid peroxidation by the oral administration of D002

Cited by 27 publications

References 18 publications

Effects of D-002, a mixture of beeswax alcohols, on osteoarthritis symptoms: a randomized placebo-controlled study

Effects of D-002, a mixture of beeswax alcohols, on osteoarthritis symptoms: a randomized placebo-controlled study

Evaluation of cholesterol-lowering and antioxidant properties of sugar cane policosanols in hamsters and humans

Efectos en ratas de los alcoholes de cera de abejas (D-002) sobre la colitis ulcerativa inducida por sulfato de dextrano y etanol

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