Gender differences in the activities of aspirin-esterases in rat tissues

Benedito, Marco Antonio Campana

doi:10.1590/s0100-879x1998000900002

Cited by 10 publications

(11 citation statements)

References 22 publications

(27 reference statements)

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“…The differences observed in this study demonstrated that sexual dimorphism in ASA-esterase activities is organ-specific and did not correspond to the sex differences already observed in rats, males showed higher enzyme activity in liver tissue and no difference in kidneys (14).…”

Section: Resultscontrasting

confidence: 95%

“…ASA metabolism initiates by hydrolysis promoted by esterases, releasing salicylic acid (SA) from the ester molecule found in different tissues of several species including humans (9)(10)(11)(12)(13). We have demonstrated a gender difference in the activity of ASA-esterases in rats (14). This difference is tissue specific and male rats show higher enzyme activity in liver tissue.…”

Section: Introductionmentioning

confidence: 99%

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Sex-dependent differences in the activities of acetylsalicylic acid-esterases in mouse kidneys

Benedito

1999

Braz J Med Biol Res

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Acetylsalicylic acid (ASA), the most used drug worldwide, is hydrolyzed to salicylic acid and acetate by esterases present in tissues of several species including humans. Sex differences in drug metabolism by rodent liver are documented in the literature. In this paper we report a difference in the activities of the esterases (ASA-esterase I and II) in the kidneys of male and female mice. In this species there is no difference between males and females in liver ASA-esterases (ASAesterase I: males 38.5 ± 7.9 (N = 5) and females 31.6 ± 7.6 (N = 5) nmol of salicylic acid formed min -1 mg protein -1 , P>0.05; ASA-esterase II: males 77.3 ± 17.4 (N = 5) and females 61.4 ± 15.1 (N = 5) nmol of salicylic acid formed min -1 mg protein -1 , P>0.05). However, in the kidneys males presented a much higher enzyme activity than females (ASA-esterase I: males 25.2 ± 6.3 (N = 5) and females 6.8 ± 0.6 (N = 5) nmol of salicylic acid formed min -1 mg protein -1 , P<0.0002; ASAesterase II: males 79.8 ± 10.1 (N = 5) and females 13.0 ± 1.1 (N = 5) nmol of salicylic acid formed min -1 mg protein -1 , P<0.0001). The difference between sexes observed in mouse kidneys could serve as a model to study the molecular basis of this sex difference and also to determine the possible involvement of pituitary and gonadal hormones in this difference in ASA-esterase activities since these hormones control the sex differences in rodent liver enzyme activity.

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Section: Resultscontrasting

confidence: 95%

Section: Introductionmentioning

confidence: 99%

Sex-dependent differences in the activities of acetylsalicylic acid-esterases in mouse kidneys

Benedito

1999

Braz J Med Biol Res

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“…In addition, some authors have proposed that the rate of ASA hydrolysis, and particularly its part governed by specific enzymes -aspirin-esterases (EC 3.1.1.55), may also play an important role in the pharmacokinetics of Aspirin ® [252][253][254][255][256]. Aspirin esterases-ascribed gender differences in ASA hydrolysis, as well as tissue-specific differences in the activity of these enzymes have been reported by some authors [254,255,[257][258][259], and one might expect an altered aspirin-esterase activity in various clinical states as the potential factors contributing to the altered blood platelets response to the Aspirin ® therapy.…”

Section: Aspirin Resistancementioning

confidence: 99%

Blood Platelet Reactivity and its Pharmacological Modulation in (People with) Diabetes Mellitus

Watała

2005

CPD

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Blood platelets play a crucial role in physiological haemostasis and in pathology of prothrombotic states, including atherosclerosis. In this paper, we review major factors underlying altered platelet reactivity, with special attention paid to abnormalities in platelet function in people with diabetes mellitus (DM). The overall picture of platelet abnormalities in DM, including altered adhesion and aggregation, is hypersensitivity of diabetic platelets to agonists. "Primed" diabetic platelets respond more frequently even to subthreshold stimuli, sooner become exhausted, consumed and finally hyposensitive, thus contributing to accelerated thrombopoiesis and release of 'fresh' hyperreactive platelets. In diabetes disturbed carbohydrate and lipid metabolism may lead to physicochemical changes in cell membrane dynamics, and consequently result in altered exposure of surface membrane receptors. These phenomena, together with increased fibrinogen binding, prostanoid metabolism, phosphoinositide turnover and calcium mobilisation often present in diabetic patients, contribute to enhanced risk of small vessel occlusions and accelerated development of atherothrombotic disease of coronary, cerebral and other vessels in diabetes. As platelet hypersensitivity in DM makes a major contribution to enhanced risk of thromboembolic macroangiopathy, and consequently enhanced morbidity and mortality, it validates use of antiplatelet agents in diabetic individuals. Platelet hyperreactivity may be cured with various antiplatelet drugs to a considerably large extent notwithstanding, evidence gathered from clinical and experimental surveys shows that this approach may not always be equally efficient in people with diabetes. Observations from clinical studies rather support the use of multifactorial strategy under such circumstances, like a combined therapy of aspirin plus either purinoreceptor blocker or GPIIb-IIIa antagonist.

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“…Метаболизм аспирина в организме начинается с гидролиза, стимулируемого ферментами эстеразами (аспирин-эстеразами), обнаруженными в нескольких тканях [18]. Салициловая кислота, продукт гидролиза аспирина, не обладает такими же фармакологическими свойствами, как аспирин.…”

Section: обзор литературных данныхunclassified

Analgesic and Anti-Inflammatory Effects of Acetylsalicylic Acid: Physiological Mechanisms

Черетаев

Khusainov

Chuyan

et al. 2020

Scientific Notes of V.I. Vernadsky Crimean Federal University. Biology. Chemistry

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Gender differences in the activities of aspirin-esterases in rat tissues

Cited by 10 publications

References 22 publications

Sex-dependent differences in the activities of acetylsalicylic acid-esterases in mouse kidneys

Sex-dependent differences in the activities of acetylsalicylic acid-esterases in mouse kidneys

Blood Platelet Reactivity and its Pharmacological Modulation in (People with) Diabetes Mellitus

Analgesic and Anti-Inflammatory Effects of Acetylsalicylic Acid: Physiological Mechanisms

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