Effects of acupuncture on behavioral, cardiovascular and hormonal responses in restraint-stressed Wistar rats

Guimarães, C.m.; Pinge, Marli Cardoso Martins; Yamamura, Ysao; Mello, Luiz Eugenio Araujo de Moraes

doi:10.1590/s0100-879x1997001200011

Cited by 20 publications

(10 citation statements)

References 9 publications

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“…These findings are consistent with previous studies showing that acupuncture can reduce expression of c-Fos and CREB, as a non-specific marker, in several stress-related structures after exposure to stress (Kim et al 2009; Liu et al 2005). Several studies have demonstrated that acupuncture plays an anxiolytic role in stress-induced neurochemical and behavioral responses (Guimaraes et al 1997; Lee et al 2004). Moreover, acupuncture attenuates stress-induced physiological responses via a central GABA pathway (Iwa et al 2006).…”

Section: Discussionmentioning

confidence: 99%

Effects of acupuncture on stress-induced relapse to cocaine-seeking in rats

et al. 2012

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Rationale Cocaine addiction is associated with high rates of relapse, and stress has been identified as a major risk factor. We have previously demonstrated that acupuncture reduces drug self-administration and dopamine release in the nucleus accumbens (NAc), a brain structure implicated in stress-induced reinstatement of drug-seeking behavior. Objective This study was conducted to investigate the effects of acupuncture on footshock-induced reinstatement of cocaine-seeking and the expression of c-Fos and the transcription factor cAMP response element-binding protein (CREB) in the NAc, used as markers of neuronal activation in conditions of stress-induced reinstatement to cocaine. Methods Male Sprague–Dawley rats were trained to self-administer cocaine (1.0 mg/kg) for 14 days, followed by extinction and then footshock stress. Acupuncture was applied at bilateral Shenmen (HT7) points for 1 min after footshock stress. Results and conclusions Acute footshock stress reinstated cocaine-seeking behavior and enhanced c-Fos expression and phosphorylated CREB (pCREB) activation in the NAc shell in cocaine pre-exposed rats. On the other hand, acupuncture at HT7, but not at control point (LI5), markedly reduced reinstatement of cocaine-seeking (86.5 % inhibition vs. control value), c-Fos expression (81.7% inhibition), and pCREB activation (79.3% inhibition) in the NAc shell. These results suggest that acupuncture attenuates stress-induced relapse by regulating neuronal activation in the NAc shell.

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Section: Discussionmentioning

confidence: 99%

Effects of acupuncture on stress-induced relapse to cocaine-seeking in rats

et al. 2012

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“…Actually, examples of such an influence, the somatovisceral reflex, have already been demonstrated (35) and comprise one of the proposed mechanisms of action of acupuncture (36)(37)(38). Therefore, it is reasonable to speculate that visceral function, particularly of the stomach in our experiment, is influenced by stimulation of the corresponding somatic area, thus preventing gastric ulcers induced by indomethacin.…”

Section: Discussionmentioning

confidence: 58%

Effect of Moxibustion at Acupoints Ren-12 (Zhongwan), St-25 (Tianshu), and St-36 (Zuzanli) in the Prevention of Gastric Lesions Induced by Indomethacin in Wistar Rats

et al. 2005

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This study was aimed at assessing the physical characteristics underlying the action of moxibustion at acupoints Ren-12 (Zhongwan), St-25 (Tianshu), and St-36 (Zuzanli) in preventing acute injuries of the gastric mucous membrane induced by indomethacin in Wistar rats. Induction of gastric lesions, by means of intragastric administration of indomethacin (100 mg/kg), in adult male Wistar rats was followed by treatment with moxibustion using Artemisia vulgaris dried leaves at 60 or 45 degrees C, heating with Artemisia vulgaris charcoal at 50 degrees C, heating with a regular tobacco cigar at 50 degrees C, and heating with a regular water pad at 50 degrees C, The effects of the different heating protocols over the gastric lesions were then compared. In addition, another group of animals was pretreated with capsaicin (100 mg/kg, s.c.), in order to lesion C fibers and, 15 days later, subjected to indomethacin administration and moxibustion treatment. Moxibustion was significantly more efficient at 60 degrees C than at 45 degrees C in preventing gastric lesions triggered by indomethacin. Moxibustion applied in acupoints provided a significant reduction of the lesion area, which was two times less than that of animals stimulated in a nonacupoint (sham group). Comparing the therapeutic effects provided by different forms of heating over the gastric lesions, the burning of dry leaves of Artemisia vulgaris was significantly more efficient in preventing gastric lesions than moxibustion made with Artemisia charcoal or tobacco (cigar) or by heating the animal with a water pad. Desensitization of the afferent sensory C fibers by capsaicin significantly diminished the ability of moxibustion to block the lesions in the gastric mucous membrane. Moxibustion can efficiently prevent indomethacin-induced gastric lesions in rats and this effect is dependent on the temperature, the material used for moxibustion, the use of acupuncture points, and the integrity of C fibers.

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“…epinephrine, norepinephrine, corticosterone, etc.) (30–32). For example, acupuncture stimulation of ST‐36 may increase adrenocortical hormone production in awake rabbits and may, in turn, inhibit adrenocortical hormone production which is induced by immobilization, heat, or cold exposure (30,31).…”

Section: Discussionmentioning

confidence: 99%