Sucrose ingestion causes opioid analgesia

Segato, F.N.; Castro-Souza, C.; Segato, E.N.; Morato, Sílvio; Coimbra, Norberto Cysne

doi:10.1590/s0100-879x1997000800011

Cited by 60 publications

(45 citation statements)

References 13 publications

(18 reference statements)

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“…Although the mechanisms underlying sucrose-induced analgesia in human infants and children is not fully established (Taddio et al, 2003;Gradin and Schollin, 2005), animal model studies suggest the involvement of the endogenous opioid system (Segato et al, 1997). For example, the effects of sucrose are abolished by the administration of the opiate receptor antagonists naloxone or naltrexone in rat pups (Blass et al, 1987).…”

Section: Discussionmentioning

confidence: 99%

Sucrose-induced analgesia is related to sweet preferences in children but not adults

Pepino

Mennella

2005

Pain

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The present study tested the hypothesis that the efficacy of sucrose in reducing pain during the Cold Pressor Test (CPT) was related to its hedonic value. To this aim, we determined the most preferred level of sucrose and the analgesic properties of 24% w/v sucrose during the CPT in 242, 5-to 10-year-old children and their mothers. Outcome measures included pain thresholds (the time at which discomfort was first indicated) and pain tolerance (the length of time the hand was kept in the cold water bath). Although children, as a group, preferred significantly higher sucrose concentrations than adults, there were individual differences that allowed us to group them on the basis of those who preferred sucrose concentrations below that used in the CPT (24% w/v) and those who preferred levels ≥ 24% w/v sucrose. Regardless of such groupings, sucrose was not an effective analgesic in adult women. Unlike adults, the more children liked sucrose, the better its efficacy as an analgesic. That is, children who preferred ≥24%w/v sucrose exhibited an increased latency to report pain and tolerated pain for significantly longer periods of time when sucrose was held in their mouths relative to water. This effect was more pronounced among normal weight when compared to overweight/at risk for overweight children. The role that dietary habits and individual differences contribute to the preferences for sweet taste and its physiological consequences in children is an important area for future research.

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Section: Discussionmentioning

confidence: 99%

Sucrose-induced analgesia is related to sweet preferences in children but not adults

Pepino

Mennella

2005

Pain

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“…Sucrose-induced analgesia during infancy develops rapidly and persists for several minutes [57]. In addition, sucrose ingestion for a relatively long period of time produces analgesia [58,59]. Acute sucrose-induced analgesia is age-dependent that means it occurs mainly during the preweaning period in rats [57].…”

Section: Sweet Solution Analgesia In Animal Studiesmentioning

confidence: 99%

Sweet Solution Analgesia

Nuseir¹,

Kassab²,

Al-Azzani³

2017

Pain Relief - From Analgesics to Alternative Therapies

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“…57,73,74 Results from a systematic review of the literature support using sucrose to provide pain relief to infants undergoing venous access. 75 As for the mechanism, some have suggested that sucrose works via the activation of endogenous opioids, 76 although others have not found support for this hypothesis. 77,78 Sucrose administration is typically done by dipping a pacifier into a solution or instilling it directly into the mouth with a syringe.…”

Section: Interventions For Young Infantsmentioning

confidence: 99%

Behavioral Approaches to Anxiety and Pain Management for Pediatric Venous Access

2008

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Pediatric venous access causes unnecessary anxiety and pain in children and, in turn, can have detrimental consequences. Behavioral approaches to pediatric venous access distress management can be organized temporally. Specifically, preparation before the procedure includes providing children with sensory and procedural information in an age-appropriate manner and providing training in coping skills. It is important to consider the timing, format, and content of the approach to provide optimal preparation for the unique circumstances of the individual patient. In addition to the child patient, preparing parents and teaching them which specific behaviors might be most helpful to their child should prove valuable to both patient and parents. During the procedure, there are benefits to providing secure and comfortable positioning. In addition, researchers recommend that adults encourage children to cope and actively engage children in distracting activities. For infants, there is support for the distress-mitigation properties of swaddling, skin-to-skin contact, breastfeeding, and sucrose. After venous access, distraction and encouragement of coping should speed recovery. In sum, research in behavioral approaches to pediatric pain management has provided recommendations for minimizing children's anxiety and pain associated with venous access. Pediatrics 2008;122:S134-S139 P EDIATRIC PAIN FROM medical procedures results in short-term suffering, but there are recent data to indicate that there are also long-term detrimental effects. Specifically, early painful insults might have lasting negative effects on neuronal development, pain threshold and sensitivity, coping strategies, emotionality, and pain perceptions. 1,2 As an example, Bijttebier and Vertommen 3 showed that children with a history of negative medical experiences showed high anxiety before venipuncture and were distressed and uncooperative during the procedure. Childhood medical pain has also been linked to later adulthood fear, pain, and avoidance of medical care. 4 In addition, high pain at medical visits predicts missed future medical appointments and poor health care follow-up. [5][6][7] Fortunately, there is a rich body of data supporting behavioral strategies that mitigate the anxiety and pain associated with pediatric medical procedures generally, 8 and children's needle-related pain in particular. 9 Nonpharmacologic or behavioral approaches to acute pediatric pain are rooted in the gate-control theory. 10,11 The theory suggests that descending nerve impulses from the brain, such as thoughts, beliefs, emotions, and attention, can influence the ascending pain signal from the tissue damage. For example, anxiety might heighten pain experience, whereas attention focused on a pleasant activity might decrease pain. Thus, behavioral interventions typically involve teaching coping, inducing relaxation, or providing distraction. Although literature documenting the efficacy of behavioral interventions for children's acute medical pain exists, the data...

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Sucrose ingestion causes opioid analgesia

Cited by 60 publications

References 13 publications

Sucrose-induced analgesia is related to sweet preferences in children but not adults

Sucrose-induced analgesia is related to sweet preferences in children but not adults

Sweet Solution Analgesia

Behavioral Approaches to Anxiety and Pain Management for Pediatric Venous Access

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