Serotonergic neurons in the caudal raphe nuclei discharge in association with activity of masticatory muscles

Le, Ribeiro-do-Valle

doi:10.1590/s0100-879x1997000100013

Cited by 17 publications

(15 citation statements)

References 17 publications

(20 reference statements)

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“…However, while some aspects require more detailed study, the present data are sufficient to conclude that the three raphe nuclei are involved differentially in the phases of feeding behavior. This conclusion derives support from electrophysiological studies in freely moving cats with implanted electrodes, which exhibit serotonergic neuron discharge related to masticatory muscle activity (13,21). Two subsets of serotonergic neurons are activated during spontaneous feeding, one by the onset of feeding that is deactivated by satiety, and another that is gradually activated by onset and gradually deactivated by satiety (21).…”

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confidence: 67%

“…Both the ROb and the RPa nuclei constitute the main serotonergic afferent sources to the trigeminal motor nucleus (11). Some RPa neurons, probably serotonergic, tend to increase their discharge pattern during licking or grooming activities (12,13). Thyrotropin hormone releasing factor administered in this nucleus promotes gastrointestinal activity in fed rats through the dorsal vagal complex (6).…”

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confidence: 99%

“…The more intense labeling of the RPa seems to emphasize its reported role as a pre-motor nucleus in somatic and autonomic motor events, particularly regarding mastication, swallowing and gastrointestinal contractility as well as gastric secretion through the vagal complex (6,10,13). The pattern of labeled cells in the ROb agrees with a role in gastrointestinal activity (6) in IF and perhaps with a hemodynamic control (22) in SF or AF, due to a greater amount of water drunk by the SF or AF, probably to compensate for food deprivation.…”

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Involvement of the caudal raphe nuclei in the feeding behavior of rats

Takase

Barone

Nogueira

2000

Braz J Med Biol Res

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Involvement of the caudal raphe nuclei (raphe pallidus, RPa; raphe magnus, RMg, and raphe obscurus, ROb) in feeding behavior of adult rats was studied by measuring c-Fos protein expression, in animals submitted to the meal-feeding model of food restriction in which the rats were fed ad libitum only from 7:00 to 9:00 h, for 15 days. The experimental groups submitted to chronic fasting, named search for food (SF), ingestion of food (IF) and satiety of food (SaF) were scheduled after a previous study in which the body weight and the general and feeding behaviors were evaluated by daily monitoring. Acute, 48-h fasting (AF) was used as control. In the chronic group, the animals presented a 16% reduction in body weight in the first week, followed by a continuous, slow rise in weight over the subsequent days. Entrainment of the sleep-wake cycle to the schedule of food presentation was also observed. The RPa was the most Fos immunopositive nucleus in the chronic fasting group, followed by the RMg. The ANOVA and Tukey test (P<0.05) confirmed these results. The IF group was significantly different from the other three groups, as also was the number of labeled cells in the RPa in SF and IF groups. Nevertheless, no significant difference was observed between RMg and RPa, or RMg and ROb in the SaF and AF. However, it is interesting to observe that the groups in which the animals were more active, searching for or ingesting food, presented a larger number of labeled cells. These results suggest a different involvement of the caudal raphe nuclei in the somatic and autonomic events of feeding behavior, corroborating the functions reported for them earlier. Feeding behavior is a complex group of functions that comprise the search, capture and ingestion of the organic and inorganic matter necessary for the sustenance of life. This behavior consists of many different components, and different brain systems are involved in the regulation of its specific aspects. As a biological rhythm, feeding behavior is organized mainly in the diencephalon by the lateral and medial hypothalamus subdivisions and the paraventricular nucleus (1-3). The lateral hypothalamus seems to control blood glucose homeostasis through glucoreceptors (also present in the nucleus tractus solitarius and the liver). Once stimulated, these receptors trigger reflexes that restore glycemia through metabolic activity of the liver, which in turn, initiates feeding behavior, particularly the searching and ingestion phases (4). Satiety, however, seems to be driven by the ventromedial hypothalamic subdivision through the release of gut hormones and cholecystokinin, and also by the distension of the gastrointestinal tract

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Involvement of the caudal raphe nuclei in the feeding behavior of rats

Takase

Barone

Nogueira

2000

Braz J Med Biol Res

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“…Third, the NRP and NRO contain neurons that discharge in association with respiration (27)(28)(29)(30), mastication and other orofacial behaviors (30,31), locomotion (30), the cardiac cycle (32,33), and blood pressure (14,34).…”

Section: Introductionmentioning

confidence: 99%

“…Artificial activation of the NRO was shown to increase the release of serotonin in target structures (37) and blockade of serotonin receptors with antagonists considerably reduces the effects of artificial activation of NRP and NRO on target neurons (18)(19)(20)(21)(22). Furthermore, the discharge of some serotonergic neurons in the NRP and NRO is associated with mastication and other orofacial behaviors and locomotion (30,31).…”

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confidence: 99%

Behavioral correlates of the activity of serotonergic and non-serotonergic neurons in caudal raphe nuclei

Ribeiro-do-Valle

Lucena

2001

Braz J Med Biol Res

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We investigated the behavioral correlates of the activity of serotonergic and non-serotonergic neurons in the nucleus raphe pallidus (NRP) and nucleus raphe obscurus (NRO) of unanesthetized and unrestrained cats. The animals were implanted with electrodes for recording single unit activity, parietal oscillographic activity, and splenius, digastric and masseter electromyographic activities. They were tested along the waking-sleep cycle, during sensory stimulation and during drinking behavior. The discharge of the serotonergic neurons decreased progressively from quiet waking to slow wave sleep and to fast wave sleep. Ten different patterns of relative discharge across the three states were observed for the non-serotonergic neurons. Several non-serotonergic neurons showed cyclic discharge fluctuations related to respiration during one, two or all three states. While serotonergic neurons were usually unresponsive to the sensory stimuli used, many non-serotonergic neurons responded to these stimuli. Several non-serotonergic neurons showed a phasic relationship with splenius muscle activity during auditory stimulation. One serotonergic neuron showed a tonic relationship with digastric muscle activity during drinking behavior. A few non-serotonergic neurons exhibited a tonic relationship with digastric and/or masseter muscle activity during this behavior. Many non-serotonergic neurons exhibited a phasic relationship with these muscle activities, also during this behavior. These results suggest that the serotonergic neurons in the NRP and NRO constitute a relatively homogeneous population from a functional point of view, while the non-serotonergic neurons form groups with considerable functional specificity. The data support the idea that the NRP and NRO are implicated in the control of somatic motor output.

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Raphe Nuclei

Hornung

2012

The Human Nervous System

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Serotonergic neurons in the caudal raphe nuclei discharge in association with activity of masticatory muscles

Cited by 17 publications

References 17 publications

Involvement of the caudal raphe nuclei in the feeding behavior of rats

Involvement of the caudal raphe nuclei in the feeding behavior of rats

Behavioral correlates of the activity of serotonergic and non-serotonergic neurons in caudal raphe nuclei

Raphe Nuclei

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