Oxidative state of ewes with different number of parity during gestation and lactation

Abstract

This study was conducted to assess the changes in some indicators of oxidative status during pregnancy and lactation in sheep of different parity. Dorset x Suffolk ewes were classified by number of parity: 1, 2 and ≥4. They were sampled before pregnancy and on the first, second, third, and fourth months, then on day 143 of pregnancy, as well as on day 5 after birth and after one month of lactation. Antioxidant capacity was found to have two reductions, the first during the second month of pregnancy and the second on day 5 of lactation. Susceptibility to lipid oxidation decreased with an increased number of parturitions. A reduction in lipid oxidation was observed on day 143 of gestation relative to the other samplings during gestation and lactation. Total glutathione peroxidase activity increased when the two reductions in antioxidant capacity took place. Ascorbic acid decreased during lactation and gestation; the lowest values were recorded in the third month of gestation. It is concluded that susceptibility to lipid oxidation decreases with the number of parturitions and that in ewes, during gestation and lactation, there is a mechanism that prevents lipid oxidation involving changes in antioxidant capacity, glutathione peroxidase and ascorbic acid.

Evaluation of enzymatic antioxidant activity and reproductive hormones near and after lambing in pregnant ewes

“…In addition to enzymatic antioxidants, the current results showed a significant decrease in the level of GSH in ewes after two weeks from lambing, which came in agreement with another study conducted on ewes (Rios et al, 2017) and cows (Khudhair et al, 2021). Many cells produce GSH as a primary antioxidant for neutralizing ROS through its associated enzymes, like peroxidase, reductase, and transferase (Ghosh et al, 2015;Cruz et al, 2014).…”

“…The current study ob-served an apparent decline in the activity of antioxidant enzymes, especially catalase, and SOD, which agrees with many researchers that involved animal parturition (Khudhair et al, 2021). Catalase and SOD are regarded as essential antioxidant enzymes that neutralize the oxidation processes that occur during stress factors (Rios et al, 2017;Al-Hassan et al, 2016;Nawito et al, 2016). A stress factor occurred during parturition, which started with the fetus completing the delivery process (Erişir et al, 2009).…”

“…Garrel et al (2010) reported a positive correlation between the GSH-px activity with normal pregnancy. A high positive correlation was discovered between normal postpartum and lactation period in animals with the activity of enzymatic antioxidants, especially GSHpx, which improves the performance of the reproductive system during this stage (Rios et al, 2017;Al-Hassan et al, 2016).…”

“…The reproductive organs consisting of ovaries and uterus are very active metabolically and are exposed to environmental agents such as oxidants (free radicals) likely to damage the DNA and proteins of the affected tissues (Fridovich, 1999;Rios et al, 2017). It has been shown that ewes enzymatic antioxidants play an important role in the female reproductive processes, and they affect reproductive performance in many ways (Rios et al, 2017).…”

Ethnoveterinary study of medicinal plants used for cattle treatment in Bojonegoro District, East Java, Indonesia

“…Research shows that curcumin added to dairy products provides increased antioxidant potential with a consequent improvement in storage stability. The antiinflammatory and antioxidant actions of curcumin already benefit the health of the sheep in this initial period of lactation and reduce somatic cell count (SCC) in the milk when the lactating sheep may experience metabolic disturbances and oxidative stress (Salinas-Rios et al 2017;Jaguezeski et al 2018).…”