Stress amelioration potential of vitamin C in ruminants: a review

Akinmoladun, O.F.

doi:10.1007/s11250-021-03026-1

Cited by 10 publications

(4 citation statements)

References 94 publications

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“…Minton [ 5 ] reported that cortisol inhibits reproductive, immune, and digestive functions. Dietary supplementation with ascorbic acid reduces cortisol release and controls the body temperature by acting as an inhibitory neurotransmitter in the hypothalamus [ 24 ]. In the present study, the plasma cortisol concentrations were lower in the TRT 1 and TRT 2 groups than in the CON group, which may be due to the stress-reducing effects of the rumen-protected L-tryptophan or L-ascorbic acid.…”

Section: Discussionmentioning

confidence: 99%

Effect of Rumen-Protected L-Tryptophan or L-Ascorbic Acid on Plasma Metabolites and Milk Production Characteristics of Lactating Holstein Cows during Summer Conditions

Kim,

Lee,

Son

et al. 2024

Animals

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This study investigated the effects of rumen-protected L-tryptophan or L-ascorbic acid supplementation on the productivity of lactating Holstein cows during a high-temperature period. Thirty cows were assigned to three dietary groups: control (CON), treatment 1 (TRT 1; rumen-protected L-tryptophan, 20 g/cow/d), and treatment 2 (TRT 2; rumen-protected L-ascorbic acid, 20 g/cow/d). As the high-temperature period progressed, the decrease in milk yield and dry matter intake (DMI) in the TRT 1 and TRT 2 groups was lower than that in the CON group. The total protein level in the plasma of the TRT 1 group was higher than that in the CON group (p < 0.05). Milk melatonin concentration was higher in the TRT 1 group than in the CON and TRT 2 groups (p < 0.05). Thus, the present results indicate that rumen-protected L-tryptophan or L-ascorbic acid has positive effects in preventing declines in DMI and milk yield by reducing heat stress in Holstein cows. In particular, rumen-protected L-tryptophan is considered effective in increasing the melatonin concentration in milk.

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Section: Discussionmentioning

confidence: 99%

Effect of Rumen-Protected L-Tryptophan or L-Ascorbic Acid on Plasma Metabolites and Milk Production Characteristics of Lactating Holstein Cows during Summer Conditions

Kim,

Lee,

Son

et al. 2024

Animals

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“…Vitamin C (VC) is a water-soluble vitamin and an effective source of antioxidants, which are extensively throughout different bodily tissues (Akinmoladun., 2021). Dietary supplementation with VC of laying hen can improve growth performance, enhance immune function, relieve stress metabolic symptoms, and increase the antioxidant capacity of chronic HS (Du et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

Optimizing Growth and Antioxidant Function in Heat-Stressed Broilers with Vitamin C and Betaine Supplementation

Li,

Yuan,

Sun

et al. 2023

Preprint

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For broiler’s health, heat stress (HS) poses a significant challenge. This study investigates the potential of vitamin C (VC) and/or betaine (Bet) to enhance growth performance, regulate serum metabolic parameters, and bolster antioxidant function aiming to mitigate the impact of cyclic HS on broilers. Two hundred Ross 308 broilers at 28 days of age were randomly assigned to five groups. The control group, housed at 24 ± 1℃, was fed a basal diet. High-temperature treatment groups, housed at 32 ± 1℃, received a basal diet with 0 (HS group), 250mg/kg VC (HSVC group), 1000mg/kg Bet (HSBe group), and 250mg/kg VC + 1000mg/kg Bet (HSVCBe group). On day 42, assessments were made on growth performance, muscle quality, serum biochemical parameters, and antioxidant function. Results revealed that HS significantly lowered (P < 0.05) average daily feed intake (ADFI), the degree of redness (a*) in pectoral and leg muscles, and serum total superoxide dismutase (T-SOD) level. It also reduced (P < 0.01) average daily gain (ADG), and serum total antioxidant capacity (T-AOC) level, while increasing (P < 0.05) shear force, serum direct bilirubin (D-BIL), uric acid (UA), and malondialdehyde (MDA) levels compared with the control group. Dietary supplementation of VC and Bet, either alone or in combination, significantly decreased shear force and serum UA level, while increasing ADG and the level of T-AOC, and T-SOD in serum antioxidant compared with the HS group (P < 0.05), with the combination yielding the most pronounced effects. In conclusion, the addition of VC and/or Bet to the diet proves effective in enhancing the growth performance of HS-exposed broilers through the positive regulation of serum chemical metabolism parameters and the alleviation of oxidative damage.

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“…It has been shown that stress worsens the immune response and causes immunosuppressive effects (Chen et al 2018). In this regard, the consequences of stress are decreases in susceptibility to infections (Akinmoladun 2021). The effect of any stress factors is associated with the activation of oxidative stress and depletion of the antioxidant system.…”

Section: Introductionmentioning

confidence: 99%

Effects of lipoperoxidation and mitochondrial state on milk yield of dairy cows under technological stress

et al. 2023

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Evaluation of the physiological state of cattle is crucial in creating healthy, high-performing dairy cattle herds. Technological stress is one of the most critical factors determining the biological potential of higher-yielding cows. This work aimed to assess the effect of technological stress on various oxidative parameters and mitochondrial states in dairy cows' blood, milk yield and milk composition. The study was conducted on the black-and-white breed of healthy herds. Regrouping, changing service personnel, and carrying out veterinary and sanitary manipulations were considered technological stress factors. The concentration of cortisol in the blood serum was studied by the immunological method. The concentrations of malonic dialdehyde (MDA), diene conjugates (D.C.), Schiff bases (S.B.), reduced glutathione and catalase activity were measured spectrophotometrically. The mitochondrial state was estimated by laser interference microscopy. While the milk yield, protein and lipid composition of cow milk were studied using an ultrasound analyzer. The researched indicators were analyzed before and for 30 days after the effect of technological stress. Results of the study suggested that technological stress caused an increase in oxidative processes, along with a reduction of antioxidant activity of blood and milk at the initial stages of registration (1-7 days). The concentration of glutathione remained reduced for 30 days after technological stress. A decrease in mitochondrial refractoriness and disintegration accompanied these processes. The milk yield indicator decreased was not restored to the values of intact animals by 30 days after technological stress. Further, the protein and lipid composition also reduced. Thus, a decrease in the quantity and quality of milk under technological stress may be mediated by the development of oxidative stress, which the refractoriness and disintegration of mitochondria might trigger.

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Stress amelioration potential of vitamin C in ruminants: a review

Cited by 10 publications

References 94 publications

Effect of Rumen-Protected L-Tryptophan or L-Ascorbic Acid on Plasma Metabolites and Milk Production Characteristics of Lactating Holstein Cows during Summer Conditions

Effect of Rumen-Protected L-Tryptophan or L-Ascorbic Acid on Plasma Metabolites and Milk Production Characteristics of Lactating Holstein Cows during Summer Conditions

Optimizing Growth and Antioxidant Function in Heat-Stressed Broilers with Vitamin C and Betaine Supplementation

Effects of lipoperoxidation and mitochondrial state on milk yield of dairy cows under technological stress

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