“…Maternal hypothyroidism is one of the most common gestational metabolic disorders and affects around 2–3% of the population [ 1 ]. Women with maternal hypothyroidism have an increased risk of miscarriage, premature birth, placental abruption, preeclampsia, gestational diabetes, and intrauterine growth restriction [ 2 , 3 , 4 , 5 , 6 , 7 , 8 ], while in hypothyroid female rats the placental development is compromised, with alteration of immunology and trophoblastic endocrine function [ 7 , 9 , 10 , 11 , 12 , 13 , 14 ]. In addition, a recent study demonstrated that maternal hypothyroidism also causes oxidative stress and endoplasmic reticulum stress at the maternal-fetal interface of rats [ 15 ], suggesting that this cellular stress may result from the failure of intrauterine trophoblastic migration observed in these animals [ 12 ].…”