Infecção por pox vírus e Aspergillus fumigatus em Bubo virginianus (Coruja jacurutu)

Echenique, Joanna V.Z.; Bandarra, Paulo Mota; Brauner, Rodrigo Kegles; Soares, Mauro Pereira; Coimbra, Marco Antônio Afonso; Schild, Ana Lúcia

doi:10.1590/s0100-736x2016000700012

Cited by 3 publications

(1 citation statement)

References 11 publications

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“…Aspergillus is found worldwide causing infections in humans and animals and is considered as one of the major respiratory pathogens in birds (Arné et al 2011), being frequently reported in the recent Brazilian veterinary literature (Spanamberg et al 2012, Silva Filho et al 2015, Echenique et al 2016. All isolates in this study were A. fumigatus obtained from healthy birds and ones with aspergillosis (without previous antifungal therapy).…”

Section: Discussionmentioning

confidence: 76%

Antifungal susceptibility profile of Aspergillus fumigatus isolates from avian lungs

et al. 2020

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ISSN 0100-736X (Print) ISSN 1678-5150 (Online) RESUMO.-[Perfil de suscetibilidade antifúngica de isolados de Aspergillus fumigatus provenientes de pulmões de aves.] Os testes de suscetibilidade são essenciais para informar o correto manejo das infecções por Aspergillus. Neste estudo apresentamos o perfil antifúngico de isolados de A. fumigatus provenientes de pulmões de aves com e sem aspergilose. Cinqüenta e três isolados foram testados quanto à susceptibilidade antifúngica ao voriconazol (VRC), itraconazol (ITZ), anfotericina B (AMB) e caspofungina (CSP) pelo método de referência de microdiluição do caldo M38-A2. Cinco isolados foram resistentes a mais de um antifúngico (CSP + AMB, VRC + ITZ e AMB + ITZ). Quinze (28%) isolados suscetíveis -com exposição aumentada (I) ao ITZ foram sensíveis ao VRC. A resistência ao AMB (>2μg/mL) foi observada em apenas quatro isolados. Onze (21%) A. fumigatus apresentaram resistência a ITZ (13%) e VRC (8%). O isolamento de fungos de amostras respiratórias tem sido considerado de utilidade limitada no diagnóstico ante mortem de aspergilose em aves. No entanto, os resultados sugerem que a detecção e o perfil de suscetibilidade a antifúngicos podem ser úteis para o monitoramento da terapia de espécies aviárias, assim como a emergência da resistência antifúngica e quais condições podem estar associadas ao evento. ABSTRACT.-Spanamberg A., Ravazzolo A.P., Denardi L.B., Hartz S.A., Santurio J.M., Driemeier D. & Ferreiro L. 2020. Antifungal susceptibility profile of Aspergillus fumigatus isolates from avian lungs. Pesquisa Veterinária Brasileira 40(2):102-106. Susceptibility testing is essential to inform the correct management of Aspergillus infections.In this study we present antifungal susceptibility profile of A. fumigatus isolates recovered from lungs of birds with and without aspergillosis. Fifty three isolates were tested for their antifungal susceptibility to voriconazole (VRC), itraconazole (ITZ), amphotericin (AMB) and caspofungin (CSP) using the M38-A2 broth microdilution reference method. Five isolates were resistant to more than one antifungal drug (CSP + AMB, VRC + ITZ and AMB + ITZ). Fifteen (28%) isolates with susceptible increased exposure (I) to ITZ were sensible to VRC. Resistance to AMB (>2μg/mL) was observed in only four isolates. Eleven (21%) A. fumigatus present resistance to ITZ (13%) and VRC (8%). Fungal isolation from respiratory samples has been regarded as being of limited usefulness in the ante mortem diagnosis of aspergillosis in birds. However, the results suggest that the detection and antifungal susceptibility profile may be helpful for monitoring of therapy for avian species and where antifungal resistance might be emerging and what conditions are associated to the event.

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Section: Discussionmentioning

confidence: 76%

Antifungal susceptibility profile of Aspergillus fumigatus isolates from avian lungs

et al. 2020

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The Owls of Brazil

2017

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Cutaneous fungal infections secondary to avian pox in Northeast Brazil

Silva,

Olinda,

Pimentel

et al. 2023

Pesq. Vet. Bras.

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This study describes the epidemiological and clinical-pathological aspects of outbreaks of avian pox diagnosed in poultry associated with fungal co-infections. A retrospective study was carried out, and cases of avian pox with suspected associated fungal infection were selected. The slides were subjected to routine and special histochemical staining in cases of suspected fungal infection, in addition to performing the immunohistochemical technique. Macroscopically, there were nodular lesions with crust formation, and histologically, the lesions were characterized by hyperplasia of the spinous layer associated with multiple eosinophilic intracytoplasmic inclusions. In seven cases, morphologically compatible structures with fungi were verified through black impregnation with GMS and strongly stained in pink with PAS. The morphotintorial aspects were suggestive of fungi belonging to the genus Aspergillus sp. and Candida sp. The diagnosis of fungal co-infections was confirmed through immunohistochemistry, with positive immunostaining for fungi of the genus Aspergillus sp. (five cases) and Candida sp. (two cases). It is concluded that the occurrence of fungal co-infections secondary to the cutaneous lesions of avian pox represents a complicating factor of the disease, favoring the weakness of these animals and death. Therefore, the investigation of associated secondary agents is necessary.

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Infecção por pox vírus e Aspergillus fumigatus em Bubo virginianus (Coruja jacurutu)

Cited by 3 publications

References 11 publications

Antifungal susceptibility profile of Aspergillus fumigatus isolates from avian lungs

Antifungal susceptibility profile of Aspergillus fumigatus isolates from avian lungs

The Owls of Brazil

Cutaneous fungal infections secondary to avian pox in Northeast Brazil

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