Atividade antimicrobiana do oleorresina de copaíba (Copaifera reticulata) frente a Staphylococcus coagulase positiva isolados de casos de otite em cães

Ziech, Rosângela Estel; Farias, Luana D’Avila; Balzan, Cláudia; Ziech, Magnos Fernando; Heinzmann, Berta Maria; Lameira, O. A.; Vargas, Agueda Castagna de

doi:10.1590/s0100-736x2013000700011

Cited by 14 publications

(13 citation statements)

References 26 publications

(29 reference statements)

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“…This disease is usually treated through topical therapy with antimicrobial agents (Rougier et al 2005). Concerns regarding antibiotic resistance press the search for alternatives (Lozina et al 2010, Ziech et al 2013, especially considering otitis, were both the causative agents and drugs used are the same in veterinary and human medicine (Lyskova et al 2007, Malayeri et al 2010. Wheat has been used for some time in wound healing and skin ointments (Tillmann et al 2014), and immune-modulatory (Hyung et al 2010), antioxidant (Souza et al 2006), and antibiotic (Ribas et al 2005, Godeiro et al 2010 properties have been described.…”

Section: Discussionmentioning

confidence: 99%

“…It is one of the most common diseases in small animal practice, characterized by clinical signs such as: itchiness, erythema, pain, and a large amount of cerumen (Plischke & Pereira 2012). The disease has a multifactorial etiology, and treatment is often hampered by growing antibiotic resistance (Lozina et al 2010, Malayeri et al 2010, Ziech et al 2013. Wheat, Triticum aestivum (sin.…”

Section: Introductionmentioning

confidence: 99%

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A randomized, double-blind, placebo-controlled study to assess the effect of an aqueous extract of Triticum aestivum on canine outer ear inflammation

et al. 2017

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ABSTRACT.-Fernandes C.P.M., Hijano A., Lima C.S., Fontoura E.G., Schramm R.C., Félix S.R. & Nobre M.O. 2017. A randomized, double-blind, placebo-controlled study to evaluate the effect of an aqueous extract of Triticum aestivum on canine outer ear inflammation. Pesquisa Veterinária Brasileira 37 (11) Outer ear otitis is a multifactorial acute or chronic inflammation of the ear canal, and treatment is often hampered by growing antibiotic resistance. Pre-clinical assessments have shown that an aqueous extract of Triticum aestiveum (wheat) can effectively reduce the symptoms associated with the disease. The purpose of this study was to assess, through a randomized, double-blind, placebo-controlled trial, the use of T. aestivum extract on canine external otitis. Thirty dogs (60 ears) met the criteria to be included in this study, and were randomly assigned a treatment group: placebo, extract, or positive control (C+). Ears were treated every day for seven days, and assessed before treatment (day zero), after treatment (day 7), and again on reassessment (day 14). Clinical assessment included: type of otitis; pinna conformation; presence or absence of itchiness, foul odor, and pain; presence of stenosis, erythema and cerumen. Furthermore, the evaluators assessed the temperature in each ear and the pH of the cerumen, and swabs were collected for bacterial and fungal isolation. All veterinarians treating and assessing the animals were blinded regarding the treatment groups. Results showed little difference in the treatment groups regarding clinical parameters. By day 7 ears treated with the C+ had elevated temperatures, when compared to the others (P<0.05), this was still true on day 14. Bacterial isolation had completely died out by day 7, however, on day fourteen the placebo group had six ears with bacterial infections, unlike the other two groups (P<0.05). The results generated herein show that a 25% wheat extract solution is effective in the reduction of clinical and microbiological parameters of external otitis, with better results when compared to a placebo, and similar results to the traditional, antibiotic/anti-inflammatory treatment.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A randomized, double-blind, placebo-controlled study to assess the effect of an aqueous extract of Triticum aestivum on canine outer ear inflammation

et al. 2017

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“…Diseases such as otitis, pharyngitis, and skin wounds have been treated empirically for millennia using this herbal component, mainly by the inhabitants of the Amazon Region (Souza‐Júnior, Damous, & Lamarão, ; Veiga Júnior, Zunino, Calixto, Patitucci, & Pinto, ). Studies have shown that copaiba oil has potential against several bacteria (Pacheco, Barata, & Duarte, ; Santos et al, ; Ziech et al, ).…”

Section: Introductionmentioning

confidence: 99%

“…that copaiba oil has potential against several bacteria (Pacheco, Barata, & Duarte, 2006;Santos et al, 2008a;Ziech et al, 2013).…”

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confidence: 99%

Antimicrobial activity of copaiba oil (Copaifera ssp.) on oral pathogens: Systematic review

Diefenbach

Muniz

Oballe

et al. 2017

Phytotherapy Research

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Copaifera ssp. produces an oil-resin that presents antiinflammatory, antitumor, antiseptic, germicidal, antifungal, and antibacterial activity. This systematic review aimed to analyze the antimicrobial action of Copaiba oil against oral pathogens, when compared to that of control substances. A search on Medline/PubMed, LILACS, SciELO, EMBASE, and SCOPUS databases were performed up to March 2017. To be included, the studies needed to perform any antimicrobial activity essay, using copaiba oil and a control substance. The antimicrobial effect of each substance, in each study, was extracted. Eleven studies were included, and several copaiba species were used. All studies showed that copaiba oil, regardless of its species, presented a bactericidal and/or bacteriostatic effect in in vitro analyzes. Only one study showed that the antimicrobial effect of the Copaifera officinalis was similar to the one found in chlorhexidine. A higher risk of bias was detected in most of the included studies. The studies demonstrated that the antimicrobial activity of copaiba oil, in most cases, is lower than chlorhexidine, which is considered the gold standard. However, there is great potential against oral bacteria. Further high quality studies are warranted in order to assess the efficacy of copaiba oil on oral pathogens.

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“…Destacando-se que muitos de seus efeitos, como o efeito antimicrobiano, antinflamatório e cicatrizante já possuem diversos estudos realizados com comprovações científicas (Vieira et al 2008, Ziech et al 2013, Melo et al 2015.…”

Section: Introductionunclassified

Avaliação da transmissibilidade ultrassônica do gel fitoterápico de Copaifera duckei Dwyer

et al. 2017

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RESUMO.-Esse estudo teve por objetivo avaliar o potencial de transmissibilidade ultrassônica de um gel fitoterápico de copaíba da espécie Copaifera duckei Dwyer na concentração de 10%. A pesquisa foi registrada junto ao Sistema Brasileiro de Biodiversidade. O gel fitoterápico de Copaifera duckei 10% foi manipulado de acordo diretrizes da Farmacopéia Brasileira e testado em um aparelho de Ultrassom (US) operado na faixa de 1 MHz. Como grupos controle foram selecionados a água destilada e o gel hidroalcoólico. A análise ocorreu de forma qualitativa e quantitativa através do modelo proposto na literatura. O US foi programado para modos de corrente pulsado/contínuo e testados nas intensidades (0,2/0,4/0,6/0 This study aimed to evaluate the potential of transmissibility of an herbal gel of Copaifera duckei Dwyer at a concentration of 10%. The research was registered with the Brazilian Biodiversity System. The gel of Copaifera duckei 10% was guidelined by the Brazilian Pharmacopoeia and tested on an Ultrasound device (US) operated in the range of 1 MHz. The control groups were selected distilled water and hydro alcoholic gel. The analysis was qualitatively and quantitatively using the model proposed in the literature. The US was scheduled to current modes pulsed/continuous and tested in the intensities (0.2/0.4/0.6/0.8/1.0W/cm2) in 1mim/cm2. The data received statistical treatment by BioEstat software 5.3 and was admitted to a significance level of ≥0.05. In continuous mode and intensity of 0.2W/cm2 gel was considered "good transmitter" at the intensity of 0.4W/ cm2 and 0.6W/cm2 a "moderate Transmitter" and the intensity of 0.8W/cm2 and 1.0W/ cm2 a "poor transmitter". It was concluded that the 10% gel C. duckei US did not attenuate US waves in any form or intensity tested; it can thus be used for this treatment being considered a good or moderate transmitter according to the intensity of US.

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Atividade antimicrobiana do oleorresina de copaíba (Copaifera reticulata) frente a Staphylococcus coagulase positiva isolados de casos de otite em cães

Cited by 14 publications

References 26 publications

A randomized, double-blind, placebo-controlled study to assess the effect of an aqueous extract of Triticum aestivum on canine outer ear inflammation

A randomized, double-blind, placebo-controlled study to assess the effect of an aqueous extract of Triticum aestivum on canine outer ear inflammation

Antimicrobial activity of copaiba oil (Copaifera ssp.) on oral pathogens: Systematic review

Avaliação da transmissibilidade ultrassônica do gel fitoterápico de Copaifera duckei Dwyer

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