Intoxicação experimental por Metternichia princeps (Solanaceae) em ovinos e bovinos

Caldas, Saulo Andrade; Brito, Marilene de Farias; Prado, Juliana da Silva; Yamasaki, Elise M.; Veronezi, L. O.; Jönck, Fernanda; Maia, Diogo dos Santos; Tokarnia, Carlos Hubinger

doi:10.1590/s0100-736x2012001000014

Cited by 2 publications

(1 citation statement)

References 2 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Veriϐicou-se a ocorrência de doença renal em caprinos causada por Metternichia princeps ( Fig.1-3), uma Solanaceae, conhecida pelos nomes populares de "café-do-mato", "trombeteira" e "jasmin-do-morro" (Caldas et al 2011, Caldas 2012, Prado 2012. Embora M. princeps esteja amplamente distribuída na Mata Atlântica, desde o estado do Rio de Janeiro até a Bahia, nunca fora associada a surtos de intoxicação em animais de fazenda até o ocorrido em caprinos no município de Itaguaí.…”

Section: Methodsunclassified

Intoxicação experimental por Metternichia princeps (Solanaceae) em coelhos

et al. 2012

Self Cite

View full text Add to dashboard Cite

Metternichia princeps, a tree that belongs to the Solanaceae family, occurs in the Atlantic Forest of Brazil, from the state of Rio de Janeiro to Bahia. In the county of Itaguaí, state of Rio de Janeiro, M. princeps was suspected to cause a lethal kidney disease in goats. The poisoning was experimentally reproduced in goats conϐirming the suspicion. Experiments were then performed in rabbits. Leaves of M. princeps were collected in the county of Itaguaí, where the poisoning in goats occurred. Eleven rabbits received the dried plant material, ten received the fresh plant and one rabbit served as control. The dehydrated leaves were ground and mixed with water. Initially the suspension was administered by stomach tube to nine rabbits and caused death of seven of them at doses from 0.125g/kg on. Two rabbits that got sick, but survived at doses of 0.0625g/kg and 0.125g/kg, received doses of 0.5 and 0.25g/kg respectively, two months later and died, indicating that no tolerance to the plant poisoning effects developed. Additionally the dried leaves administered six months after collection to two rabbits at doses of 0.5 and 1g/kg respectively, caused death only of the rabbit that received the dose of 1g/kg, indicating that the stored leaves lost toxicity. Fresh sprouts caused death in three of six rabbits at doses of 1.55g/kg to 3g/kg. Fresh mature leaves caused death in one of four rabbits at the dose of 2g/kg, what suggests that there is no difference in toxicity between mature leaves and sprouts. The dried leaves caused death of rabbits at smaller doses than fresh leaves, what can be explained by the way of administration of the plant; dried leaves were given within a few minutes, whilst fresh leaves were ingested during one or two days, a fact that may inϐluence absorption of the toxic principle. In all experiments with the dried and fresh leaves (sprouts and mature leaves) of M. princeps, liver and heart lesions predominated. The course of the poisoning was peracute to acute. The rabbits became apathetic with pale and cyanotic mucosae and cold ears; they fell down with struggling movements, vocalization and spaced breathing and died. At postmortem examination, the liver was pale with marked hepatic lobules; the other organs were congested and blood vessels were ingurgitated. The histopathological examination revealed as the more important changes in the liver, intense, especially centrilobular congestion, severe swelling of the hepatocytes, and foci of incipient necrosis of hepatocytes. In the heart, beside congestion, small groups of eosiophilic cardiac ϐibers, with nuclear picnosis and vacuolation were found. In the kidney, congestion and swelling of epithelial cells

show abstract

Section: Methodsunclassified

Intoxicação experimental por Metternichia princeps (Solanaceae) em coelhos

et al. 2012

Self Cite

View full text Add to dashboard Cite

show abstract

Intoxicação por Metternichia princeps (Solanaceae) em caprinos no Estado da Bahia

et al. 2015

View full text Add to dashboard Cite

RESUMO.-Descreve-se um surto de intoxicação por Metternichia princeps em caprinos no Estado da Bahia. De oito caprinos, três morreram, dos quais dois foram necropsiados; cinco não adoeceram. Os principais sinais clínicos caracterizaram-se por secreção nasal mucosa, emagrecimento, diarreia, apatia, debilidade leve, andar cambaleante, flexão dos membros torácicos e pélvicos, decúbito esterno-abdominal e decúbito lateral, seguidos de morte após aproximadamente dois dias de evolução clínica. Na necropsia foi observado edema pulmonar, hidrotórax, hidropericárdio, ascite, rins pálidos, edema perirrenal e hemorragias no tecido subcutâneo. Microscopicamente nos rins havia acentuada necrose de coagulação do epitélio tubular e túbulos com regeneração do epitélio. No pulmão havia acentuada congestão associada a edema interalveolar e interseptal. Na bioquímica sanguínea observou-se aumento na ureia, creatinina e creatinina fosfoquinase.TERMOS DE INDEXAÇÃO: Plantas tóxicas, Metternichia princep, Solanaceae, nefrose, edema pulmonar, ruminante, intoxicação por plantas. INTRODUÇÃOMetternichia princeps, árvore da família Solanaceae, é popularmente conhecida como "trombeteira", "café-do-mato" e "jasmim-do-morro" (Lorenzi 2009. Casos de intoxicação espontânea só foram registrados em caprinos no Estado do Rio de Janeiro (Caldas et al. 2011). Experimentalmente a intoxicação foi reproduzida em caprinos, bovinos, ovinos e coelhos , Maran et al. 2012 Out of eight goats three showed symptoms of poisoning and died; on two of them post-mortem examinations were performed. The main clinical signs were nasal mucous secretion, weight loss, diarrhea, lethargy, mild weakness, staggering gait, flexion of the fore and hind limbs, sternal recumbence, and lateral recumbence followed by death after approximately two days of clinical manifestations. The serum concentration of urea and creatinine and the serum activities of creatine phosphokinase were increased. At necropsy pulmonary edema, hydrothorax, hydropericardium, ascites, pale kidneys, perirenal edema and hemorrhages in the subcutaneous tissue were observed. Microscopically the kidneys showed accentuated coagulation necrosis of the tubular epithelium and tubules and epithelial regeneration. In the lungs there was accentuated congestion associated with interalveolar and interseptal edema.

show abstract

Intoxicação experimental por Metternichia princeps (Solanaceae) em ovinos e bovinos

Cited by 2 publications

References 2 publications

Intoxicação experimental por Metternichia princeps (Solanaceae) em coelhos

Intoxicação experimental por Metternichia princeps (Solanaceae) em coelhos

Intoxicação por Metternichia princeps (Solanaceae) em caprinos no Estado da Bahia

Contact Info

Product

Resources

About