Diagnóstico do controle e perfil de sensibilidade de nematódeos de ovinos ao albendazol e ao levamisol no norte de Minas Gerais

Duarte, Eduardo Robson; Silva, Rayana B.; Vasconcelos, Viviane de Oliveira; Nogueira, Flávia Aparecida; Oliveira, Neide Judith Faria de

doi:10.1590/s0100-736x2012000200010

Cited by 23 publications

(10 citation statements)

References 15 publications

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“…Lima et al (2010) relataram redução de 100% na contagem de ovos nas fezes após tratamento com ivermectina em ovinos nos estados do Ceará e Pernambuco, respectivamente. Em relação ao albendazol, os autores encontraram em alguns municípios de Pernambuco, resistência ao mesmo vermífugo numa das propriedades ovinas avaliadas, a qual apresentou eficácia de 75,72%, assemelhando-se ao resultado do presente trabalho que foi de 82%, Duarte et al (2012) macrocíclicas, e imidotiazoles) em ovinos, causa preocupação (Martínez-Valladares et al, 2015).…”

Section: Resultsunclassified

Resistência anti-helmíntica em nematoides gastrintestinais de ovinos

Batista

Ramos

Brito

et al. 2017

Pubvet

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RESUMO.Objetivou-se verificar a existência de resistência anti-helmíntica a ivermectina e albendazol em nematoides gastrintestinais de ovinos em propriedades dos municípios de Janaúba e Nova Porteirinha. O experimento foi conduzido em 4 propriedades e foram utilizados 88 animais. Nas fazendas (A e B), testou-se o anti-helmíntico ivermectina e nas fazendas (C e D), ivermectina e albendazol. A redução na contagem de ovos por grama de fezes (RCOF) foi determinada utilizando fórmula específica, indicando resistência com índice menor a 95%. Houve resistência dos nematoides gastrintestinais ao albendazol nas duas propriedades em que foi testado e a ivermectina em três das quatro propriedades. Na fazenda C, a ivermectina apresentou-se eficácia de 97%. O nematoide de maior prevalência foi o Haemonchus contortus.Palavras chave: helmintos, ivermectina, albendazol, anti-helmínticos, eficácia Antihelminth resistance in gastrointestinal nematodes of sheep ABSTRACT. The objective was to verify the existence of antihelminthic resistance in gastrointestinal nematodes of sheep in properties of the municipalities of Janaúba and Nova Porteirinha. The experiment was conducted at 4 properties, and was done as coproparasitological analyzes in fecal samples of 88 animals. In the farms (A and B) there was a division of the animals into two groups: control and immersion and in farms (C and D) in three groups: control, ivermectin and albendazole. Each group has 6 animals. The reduction of fecal grain contamination (RCOF) was determined based on the specific formula, indicating a percentage greater than or equal to 95%. There was resistance of the gastrointestinal nematodes to albendazole in the two properties in which it was tested and ivermectin in three of the four properties. In farm C, ivermectin showed efficacy of 97%. The most prevalent nematode was Haemonchus contortus.

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Section: Resultsunclassified

Resistência anti-helmíntica em nematoides gastrintestinais de ovinos

Batista

Ramos

Brito

et al. 2017

Pubvet

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“…Duarte et al (2012), testing this anthelmintic in Northern Minas Gerais State, Southeastern Brazil, achieved efficacy ranging from 90% to 100%. However, Leathwick et al (2012) observed resistance to this anthelmintic (efficacy<70%) in New Zealand sheep and George et al (2011) observed efficacies from 53% to 81% in sheep from Trinidad and Tobago.…”

Section: Discussionmentioning

confidence: 99%

ANTHELMINTIC RESISTANCE IN SMALL RUMINANTS FROM THE SEMIARID OF PARAÍBA STATE, BRAZIL/Resistência anti-helmíntica em pequenos ruminantes do semiárido da Paraíba, Brasil

Melo¹,

Vilela²,

Feitosa³

et al. 2013

Ars Vet

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“…For the albendazole + levamizole + ivermectin combination, only one population of T. colubriformis was considered resistant to this medication, whereas the remaining nematode populations evaluated, T. colubriformis, T. axei, C. curticei, S. papillosus and O. columbianum, were diagnosed as susceptible to this compound. Although albendazole, levamizole and ivermectin were not tested separately, studies conducted worldwide with benzimidazoles reinforce the inefficacy of this antiparasitic class against helminths parasitizing sheep and goats (Cunha Filho et al, 1998;Melo et al, 1998;Sczesny-Moraes et al, 2010;Duarte et al, 2012;Mahineu et al, 2014). However, there are several reports of helminthic resistance against levamizole, the active principle in ruminants (Souza and Thomas-Soccol, 1997;Souza and Thomas-Soccol, 1997), and susceptible populations remain, depending on the region (Lima et al, 2010;Duarte et al, 2012).…”

Section: Studiesmentioning

confidence: 99%

“…Although albendazole, levamizole and ivermectin were not tested separately, studies conducted worldwide with benzimidazoles reinforce the inefficacy of this antiparasitic class against helminths parasitizing sheep and goats (Cunha Filho et al, 1998;Melo et al, 1998;Sczesny-Moraes et al, 2010;Duarte et al, 2012;Mahineu et al, 2014). However, there are several reports of helminthic resistance against levamizole, the active principle in ruminants (Souza and Thomas-Soccol, 1997;Souza and Thomas-Soccol, 1997), and susceptible populations remain, depending on the region (Lima et al, 2010;Duarte et al, 2012). The increased efficacy of the albendazole + levamizole + ivermectin combination was also reported by Buzzulini et al (2007) and Holsback et al (2013) for sheep from the states of São Paulo (Southeast region of Brazil) and Paraná (South region of Brazil), respectively.…”

Section: Studiesmentioning

confidence: 99%

Susceptibility of helminth species parasites of sheep and goats to different chemical compounds in Brazil

Bichuette

Lopes

Gomes

et al. 2015

Small Ruminant Research

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A total of 160 sheep and 160 goats were necropsied to evaluate the degrees of susceptibility or resistance of different helminth species to 0.2 mg/kg ivermectin (subcutaneous route), 0.2 mg/kg moxidectin (subcutaneous route), 100 mg/kg trichlorfon (administered orally) and the combination of 5 mg/kg albendazole + 7.5 mg/kg levamizole + 0.2 mg/kg ivermectin (administered orally). To achieve this objective, eight experiments were performed, four with each animal species. In each experiment, naturally infected sheep or goats were divided into five groups with eight individuals each, as follows: T01, untreated control; T02, trichlorfon; T03, ivermectin; T04, moxidectin; and T05, albendazole + levamizole + ivermectin, based on average counts of eggs per gram of feces (EPG) before treatment (experimental dates −3, −2 and −1). Seven days post-treatment (DPT), all animals were euthanized and necropsied for the recovery of helminth burdens. Based on the obtained results, it is possible to conclude that the resistance of some helminth species parasitizing sheep and goats is different for the tested chemical groups. Ivermectin, at 0.2 mg/kg dosage, presented inferior anthelmintic efficacy against some of these parasites. Of these species, populations of Haemonchus contortus, followed by Trichostrongylus colubriformis, Cooperia curticei and Oesophagostomum columbianum, exhibited the greatest resistance to the aforementioned chemical compound, whereas Trichostrongylus axei displayed higher susceptibility to ivermectin. For moxidectin (0.2 mg/kg), 75% of all H. contortus populations were considered resistant to this drug, whereas all populations of T. colubriformis, T. axei, C. curticei and O. columbianum were susceptible. Trichlorfon and albendazole + levamizole + ivermectin were effective against the analyzed nematode populations, except against one strain of H. contortus and one strain of T. colubriformis. All three Strongyloides papillosus populations evaluated were susceptible to the tested formulations, except for moxidectin, as this compound presented low efficacy indices against all populations of this helminth species.

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Diagnóstico do controle e perfil de sensibilidade de nematódeos de ovinos ao albendazol e ao levamisol no norte de Minas Gerais

Cited by 23 publications

References 15 publications

Resistência anti-helmíntica em nematoides gastrintestinais de ovinos

Resistência anti-helmíntica em nematoides gastrintestinais de ovinos

ANTHELMINTIC RESISTANCE IN SMALL RUMINANTS FROM THE SEMIARID OF PARAÍBA STATE, BRAZIL/Resistência anti-helmíntica em pequenos ruminantes do semiárido da Paraíba, Brasil

Susceptibility of helminth species parasites of sheep and goats to different chemical compounds in Brazil

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