Ocorrência e fatores de risco associados à infecção por Corynebacterium pseudotuberculosis em caprinos e ovinos do semiárido paraibano

Andrade, José Sóstenes Leite de; Azevêdo, Sérgio Santos de; Teles, José Andreey Almeida; Higino, Severino Silvano dos Santos; Azevedo, Edisio Oliveira de

doi:10.1590/s0100-736x2012000200004

Cited by 10 publications

(17 citation statements)

References 7 publications

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“…In field conditions, disease control is impaired due to an inability to detect subclinical cases that maintain and disseminate C. pseudotuberculosis without having an impact SOUZA et al, 2011). A serological test (ELISA) would probably result in a higher CL prevalence in the herds analyzed by Andrade et al (2012). No.…”

Section: Discussionmentioning

confidence: 99%

“…It is considered a significant obstacle for goat breeding around the world, with some countries having a prevalence rate of up to 80% (VESCHI, 2011). In Brazil, it is estimated that most herds are infected, the clinical prevalence of which can vary from 5% to 50% (ANDRADE et al, 2012;PEREIRA et al, 2017;RIZZO et al, 2017;SOUZA et al, 2011;SOUZA et al, 2014). In addition to economic concerns, disease control is important for preserving human health.…”

Section: Introductionmentioning

confidence: 99%

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Characterization of caseous lymphadenitis in caprine animals slaughtered in a semi-arid region of Brazil

Barnabé

Silva

Viana

et al. 2019

SCA

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In the Northeast of Brazil, goat breeding plays an important socioeconomic and strategic role in coexistence within the semi-arid region. The rural nature of the species and adaptations that are appropriate for the climate are some of the characteristics that favor the Northeast as the largest national producer of goats (93% of the national herd). In spite of this, sanitary deficiencies facilitate the appearance and diffusion of pathogenic agents that compromise the productivity, e.g., Corynebacterium pseudotuberculosis, which are widespread in the national herd and cause damages in the industry. The objective of this study was to characterize caseous lymphadenitis (CL) in lamb cuttings at semi-arid abattoirs. The research was carried out between March and August 2017 at the Municipal Abattoir of Patos, State of Paraíba, Brazil, where the caprines from this region are slaughtered. We studied 304 animals with no defined racial pattern, of both the sexes, characterized according to their age group as evidenced by their teeth, submitted to ante-and post-mortem examinations with microbiological confirmation. Cheek material was processed for diagnostic confirmation, using the techniques of isolation and microbiological identification (gold standard). The bacteriological examination confirmed the presence of the agent in 21.38% of the animals, in which 13.16% were females and 8.22% were males. Of those affected, 11.51% had the clinical form of the disease, while 9.87% had the subclinical form and 1.31% had both the clinical form as well as the internal impairment. The precrural (25.71%), mammary (11.43%), and prescapular (11.43%) lymph nodes were the most affected. Internally, the most affected were the liver (63.33%), lung (13.33%), and medium mediastinal lymph nodes (10%). The presence of skin lesion/scars (Odds ratio = 2.394, 95% CI = 1.371 -4.182, p = 0.003) and sex (females) (Odds ratio = 1.845, 95% CI = 1.053 -3.232, p = 0.044) were found to be risk factors. CL is present in goats from the intermediate geographical region of Patos, reinforcing the need for control measures, with attention to the inspection of animals in the slaughter line. ResumoNo Nordeste do Brasil a caprinocultura desempenha importante função socioeconômica e estratégica na convivência em região semiárida. A boa adaptação ao clima somado a rusticidade da espécie são algumas das caraterísticas que favorecem o Nordeste como maior produtor nacional (93% do efetivo). Apesar dessa condição, deficiências sanitárias proporcionam surgimento e difusão de agentes patogênicos que comprometem a produtividade, destacando-se o Corynebacterium pseudotuberculosis, difundido no rebanho nacional e que gera prejuízos à atividade. O objetivo deste estudo foi caracterizar a Linfadenite Caseosa (LC) na caprinocultura de corte em abatedouro do semiárido. Desenvolveu-se a pesquisa entre março e agosto 2017 no Abatedouro Municipal de Patos, Estado da Paraíba, Brasil, onde ocorre abate de caprídeos provenientes desta região geográfica intermediária. Foram estudados 304...

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Characterization of caseous lymphadenitis in caprine animals slaughtered in a semi-arid region of Brazil

Barnabé

Silva

Viana

et al. 2019

SCA

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“…The isolation and identification of the agent in caseous material drained from the abscesses or organs is considered as the gold standard for the diagnosis of CL FONTAINE, 2007). Nevertheless, some infected animals may not show the clinical signs such as abscess formation, which may be a limiting factor in performing the technique.…”

Section: Discussionmentioning

confidence: 99%

“…Studies using the isolation agent were performed in Paraíba by Andrade et al (2012), which evaluated goats and sheep in the semi-arid region of Brazil, where they observed 7.7% of the animals with clinical signs of CL and isolated the agent in 68.2% of the samples. Souza et al (2011) evaluated sheep slaughtered in a municipality in the Cariri region of Paraíba, originated in Bahia, Pernambuco, and Paraíba; the macroscopic lesions like CL were identified in 15.9% of the inspected animals and C. pseudotuberculosis was isolated in 74.5% of the cultured samples.…”

Section: Discussionmentioning

confidence: 99%

Seroprevalence of caseous lymphadenitis in goats sold in an animal fair in the northeastern semi-arid region of Brazil

Alves

Farias

Lima³

et al. 2018

SCA

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Goat farming in the northeastern regions of Brazil plays an important role in the socio-economic functions of the country. However, high rates of morbidity and mortality occur in the animals, caused primarily by infectious diseases like caseous lymphadenitis, which is widespread in goat herds; this causes serious economic losses to the farming business. Although events such as animal fairs are common in the region, wherein most of the goats and sheep are sold, the risk of disease transmission remains, since the health condition of the animal is unknown. The aim of this study was to determine the frequency of anti-Corynebacterium pseudotuberculosis antibodies present in the goats sold at the animal fair of Tabira -PE, Northeastern semi-arid. Serum samples from 233 goats were collected from the period of November 2014 to June 2015. The diagnosis of infection by C. pseudotuberculosis was made using the indirect ELISA technique. The number of goats seropositive for C. pseudotuberculosis was identified as 87 (37.34%; 95% CI = 31.38 -43.71%). Of the nine flocks evaluated, five (55.55%) were positive. Thus, it is suggested that infection by C. pseudotuberculosis is widespread in the goats sold at the animal fairs in the semi-arid Northeastern, reinforcing the need for disease diagnosis in goat herds in the region for the possible implementation of disease control programs. Key words: Agglomerations. Caseous lymphadenitis. Goats. Serology. ResumoA caprinocultura se destaca na região Nordeste do Brasil por desempenhar importante função socioeconômica. Contudo altas taxas de morbidade e mortalidade ocorrem nas propriedades causadas principalmente por doenças infecciosas, destacando-se a linfadenite caseosa, que se encontra amplamente difundida nos rebanhos caprinos, acarretando sérios prejuízos econômicos à atividade. Eventos do tipo

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“…Afecções como a artrite encefalite caprina (AEC) e a linfadenitecaseosa (LC) são mundialmente disseminadas, inclusive no Brasil, e apesar de não causarem sintomatologia expressiva na maioria das vezes, estão implicadas na baixa produtividade dos animais (Ribeiro et al 2011, Andrade et al 2012. O vírus da AEC (VAEC) e Corynebacterium pseudotuberculosis, agente etiológico da LC, apresentam em comum o tropismo pelas células da série monócito-macrófago, que disseminam os agentes no hospedeiro (Lara et al 2005, Blacklaws 2012.…”

Section: Introductionunclassified

Fagocitose intensificada de Corynebacterium pseudotuberculosis por células da série monócito-macrófago de caprinos naturalmente infectados pelo vírus da artrite encefalite

et al. 2012

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Pesq. Vet. Bras. 32(12):1225-1229, dezembro 2012 1225 RESUMO.-A Artrite Encefalite Caprina (AEC) e a Linfadenite Caseosa (LC) possuem alta incidência e transmissibilidade em pequenos ruminantes. Como ambas possuem tropismo por monócitos-macrófagos e afetam mecanismos da resposta inata do hospedeiro, acredita-se que a AEC predispõe o animal a infecções por Corynebacteruim pseudo- Caprine arthritis encephalitis (CAE) and caseous lymphadenitis (CL) have high incidence and transmissibility in small ruminants. Since both virus have tropism for macrophages and monocytes and affect the innate immune response, it is believed that CAE can predispose the animal to infection by Corynebacteruim pseudotuberculosis, the etiological agent of CL. To conϐirm this hypothesis, we evaluated phagocytosis from the monocyte-macrophage cells from 30 Saanen goats. Goats were uniformly divided in two groups according to results of agar gel immunodiffusion test for CAE virus (CAEV). Peripheral blood mononuclear cells were isolated by density gradient centrifugation and the monocyte-macrophage cells were isolated from the mononuclear cells by their adhesion properties in plaques. Afterwards, phagocytosis of C. psudotuberculosis was performed for two hours at 37°C, 5% of CO 2 , and assessed by microscopic visualization. There was no difference in the percentage of monocyte-macrophage cells that phagocytozed C. bovis between groups (P=0.41). However, when phagocytosis rates were classiϐied according to the number of C. pseudotuberculosis phagocyted, the percentage of monocyte-macrophage cells that internalized more than 12 bacteria were higher in serologically CAEV positive animals compared to the serologically negative ones (P<0.001). Furthermore, a positive and signiϐicant correlation (r = 0.488; P = 0.006) between the percentage of monocyte-macrophage cells that internalized more than 12 bacteria and the percentage of monocyte that were carrying out phagocytosis was also encountered in serologically CAEV positive goats, however the same were not observed in serologically negative ones. These results demonstrated an alteration in the intensity of C. pseudotuberculosis phagocytosis by monocytes-macrophages from goats infected by CAEV. Thus, these results indicated that goats infected with CAEV may be more susceptible to CL. Fagocitose intensiϐicada de

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Ocorrência e fatores de risco associados à infecção por Corynebacterium pseudotuberculosis em caprinos e ovinos do semiárido paraibano

Cited by 10 publications

References 7 publications

Characterization of caseous lymphadenitis in caprine animals slaughtered in a semi-arid region of Brazil

Characterization of caseous lymphadenitis in caprine animals slaughtered in a semi-arid region of Brazil

Seroprevalence of caseous lymphadenitis in goats sold in an animal fair in the northeastern semi-arid region of Brazil

Fagocitose intensificada de Corynebacterium pseudotuberculosis por células da série monócito-macrófago de caprinos naturalmente infectados pelo vírus da artrite encefalite

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