Intoxicação espontânea por Ipomoea carnea subsp. fistulosa (Convolvulaceae) em bovinos no Pantanal Matogrossense

Antoniassi, Nadia Aline Bobbi; Ferreira, Eduardo V.; Santos, Carlos Henrique dos; Arruda, Laura Peixoto de; Campos, João Losano E.; Nakazato, Luciano; Colodel, Edson Moleta

doi:10.1590/s0100-736x2007001000005

Cited by 30 publications

(15 citation statements)

References 17 publications

(17 reference statements)

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“…fistulosa em bovinos, ovinos e bubalinos, mas não pode ser descartada a ocorrência da doença nessas espécies, como ocorre no Pantanal Matogrossense em bovinos (Antoniassi et al 2007) e no Vale do São Francisco em bovinos e ovinos (Tokarnia et al 1960(Tokarnia et al , 2000. É necessário estar atento para a possível ocorrên-cia da intoxicação nessas espécies para, nesse caso, evitar a difusão do hábito de ingerir a planta, mediante a eliminação dos animais ou rebanhos que a ingerem.…”

Section: Discussionunclassified

“…fistulosa, (Convolvulaceae), conhecida como algodão bravo, canudo, manjorana, capa-bode ou mata-cabra, é uma planta que causa doença de depósito lisossomal em ruminantes, principalmente em caprinos (Tokarnia et al 1960, Armien et al 2007), mas tem sido observada também em bovinos (Tokarnia et al 1960, Antoniassi et al 2007) e ovinos (Tokarnia et al 1960).…”

Section: Introductionunclassified

“…No Mato Grosso, I. carnea subsp. fistulosa ocorre comumente no Pantanal Mato-grossense, e casos de intoxicação em bovinos têm sido descritos (Antoniassi et al 2007). No Estado do Rio de Janeiro I. carnea subsp.…”

Section: Introductionunclassified

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Intoxicação por Ipomoea carnea subsp. fistulosa (Convolvulaceae) em caprinos na Ilha do Marajó, Pará

et al. 2009

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Ipomoea carnea subsp. fistulosa é uma planta que contém swainsonina causando doença de depósito lisossomal em ruminantes, principalmente em caprinos na região Nordeste do Brasil. Para o estudo das plantas tóxicas da Ilha de Marajó, foram visitadas sete propriedades rurais na Ilha de Marajó, seis localizadas no município de Cachoeira do Arari e uma no município de Soure. Em todas as propriedades visitadas as pastagens eram constituídas de campo nativo, tinham pouca disponibilidade de forragem e I. carnea subsp. fistulosa encontrava-se em grande quantidade. Nas três propriedades onde eram criados caprinos foram observados animais com sinais nervosos, incluindo tremores de intenção, aumento da base de sustentação quando em estação, ataxia, hipermetria, nistagmo, paresia espástica ou debilidade, alterações posturais, perda de equilíbrio e quedas. Em duas fazendas a prevalência foi de 32% (23/71) e 100% (32/32) e em outra havia um animal com sinais acentuados e o resto do rebanho, de 19 caprinos, não foi examinado clinicamente. Bovinos, ovinos e bubalinos não foram afetados. Foram eutanasiados e necropsiados seis caprinos que apresentavam sinais clínicos acentuados. Macroscopicamente não foram observadas alterações. Na histologia observou-se vacuolização do pericário de neurônios e do citoplasma de células epiteliais da tireóide, rim, fígado, pâncreas e macrófagos de diversos órgãos. No sistema nervoso central a vacuolização era mais grave nos neurônios de Purkinje do cerebelo e nos neurônios dos núcleos cerebelares e do tronco encefálico. Observaram-se também degeneração walleriana dos axônios e gliose. A alta freqüência da intoxicação nas três fazendas que criavam caprinos sugere que a intoxicação por I. carnea subsp. fistulosa é muito importante para caprinos na Ilha de Marajó, onde há abundante quantidade da planta, que permanece verde durante todo o período seco.

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Section: Discussionunclassified

Section: Introductionunclassified

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Intoxicação por Ipomoea carnea subsp. fistulosa (Convolvulaceae) em caprinos na Ilha do Marajó, Pará

et al. 2009

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“…has been held responsible for severe episodes of intoxication in the tropics and subtropics. There are reports of spontaneous poisoning, especially in goats, in parts of Brazil, Sudan, India, Mozambique and Argentina (Damir et al 1987, De Balogh et al 1999, Rodriguez Armesto et al 2004, Barbosa et al2006, Antoniassi et al 2007, Armien et al 2007, Barbosa et al 2007, Ríos et al 2008). The plant contains as main toxic component swainsonine which inhibits lysosomal enzyme α-mannosidase and mannosidase II Golgi apparatus (Colegate et al 1979, Molyneux & James 1982.…”

Section: Introductionmentioning

confidence: 99%

Experimental poisoning of goats by Ipomoea carnea subsp. fistulosa in Argentina: a clinic and pathological correlation with special consideration on the central nervous system

et al. 2012

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Ipomoea carnea subsp. fistulosa, aguapei or mandiyura, is responsible for lysosomal storage in goats. The shrub contains several alkaloids, mainly swansonine which inhibits lysosomal α-mannosidase and Golgi mannosidase II. Poisoning occurs by inhibition of these hydrolases. There is neuronal vacuolation, endocrine dysfunction, cardiovascular and gastrointestinal injury, and immune disorders. Clinical signs and pathology of the experimental poisoning of goats by Ipomoea carnea in Argentina are here described. Five goats received fresh leaves and stems of Ipomoea. At the beginning, the goats did not consume the plant, but later, it was preferred over any other forage. High dose induced rapid intoxication, whereas with low doses, the course of the toxicosis was more protracted. The goats were euthanized when they were recumbent. Cerebrum, cerebellum, medulla oblongata, pons and colliculi, were routinely processed for histology. In nine days, the following clinical signs developed: abnormal fascies, dilated nostrils and abnormal postures of the head, cephalic tremors and nystagmus, difficulty in standing. Subsequently, the goats had a tendency to fall, always to the left, with spastic convulsions. There was lack in coordination of voluntary movements due to Purkinje and deep nuclei neurons damage. The cochlear reflex originated hyperreflexia, abnormal posture, head movements and tremors. The withdrawal reflex produced flexor muscles hypersensitivity at the four legs, later depression and stupor. Abnormal responses to sounds were related to collicular lesions. Thalamic damage altered the withdrawal reflex, showing incomplete reaction. The observed cervical hair bristling was attributed to a thalamic regulated nociceptive response. Depression may be associated with agonists of lysergic acid contained in Ipomoea. These clinical signs were correlated with lesions in different parts of the CNS.

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“…The clinical and pathological features seen in herbivores poisoned by S. carpinifolia are indistinguishable from those described in livestock poisoned by plants of the genera Swainsona in Australia (Colegate et al 1979), Astragalus and Oxytropis in the United States (Stegelmeier et al 1995, Pϐister et al 2003, Ipomoea spp. (Barbosa et al 2006, Barbosa et al 2007, Armién et al 2007, Antoniassi et al 2007, and Turbina cordata (Dantas et al 2007) in Brazil. This paper describes the pathologic ϐindings observed in fetuses from livestock poisoned by Sida carpinifolia.…”

Section: Introductionmentioning

confidence: 99%

Pathological findings in fetuses of goats and cattle poisoned by Sida carpinifolia (Malvaceae)

et al. 2012

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In Brazil, the consumption of Sida carpinifolia by livestock has been associated with neurological diseases linked to lysosomal storage disorders. This paper describes the pathological ϐindings in two caprine fetuses from dams that were experimentally poisoned with S. carpinifolia. The goats were orally dosed with 10 and 13g/kg of a paste of green chopped S. carpinifolia for 30 days and were observed for an additional 15 days period after the last dosage with the plant; thereafter they were euthanized and necropsied. The dams showed only slight clinical signs. The study also includes the ϐindings in one bovine fetus from a naturally S. carpinifolia poisoned cow which showed mild incoordination, generalized tremors, staggering, and frequent falls. The cow was euthanized and necropsied. While there were no signiϐicant histopathological changes in the goats, in the cow vacuolation of Purkinje neurons of the cerebellum, pancreatic acinar cells, and thyroid follicular cells were observed. The main microscopic changes observed in the caprine and bovine fetuses were vacuolation in the epithelium of renal tubules, thyroid follicular cells, and Purkinje neurons of the cerebellum. Transmission electron microscopy of sections from CNS of the cow and its fetus revealed vacuoles containing ϐine granular material surrounded by membrane. Lectin-histochemistry of CNS sections from goat fetuses marked lightly to sWGA lectins, WGA, and Con-A.INDEX TERMS: Poisonous plants, Swainsonine, Sida carpinifolia, Malvaceae, plant poisoning, lysosomal storage disease, pathological ϐindings, lectin-histochemistry, transmission electron microscopy, caprine and bovine fetuses.

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Intoxicação espontânea por Ipomoea carnea subsp. fistulosa (Convolvulaceae) em bovinos no Pantanal Matogrossense

Cited by 30 publications

References 17 publications

Intoxicação por Ipomoea carnea subsp. fistulosa (Convolvulaceae) em caprinos na Ilha do Marajó, Pará

Intoxicação por Ipomoea carnea subsp. fistulosa (Convolvulaceae) em caprinos na Ilha do Marajó, Pará

Experimental poisoning of goats by Ipomoea carnea subsp. fistulosa in Argentina: a clinic and pathological correlation with special consideration on the central nervous system

Pathological findings in fetuses of goats and cattle poisoned by Sida carpinifolia (Malvaceae)

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