Hepatite infecciosa canina: 62 casos

Inkelmann, Maria Andréia; Rozza, Daniela Bernadete; Fighera, Rafael A.; Kommers, Gláucia D.; Graça, Dominguita Lühers; Irigoyen, Luiz Francisco; Barros, Claudio S.L.

doi:10.1590/s0100-736x2007000800002

Cited by 11 publications

(13 citation statements)

References 10 publications

(26 reference statements)

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“…Esses achados também foram descritos por Inkelmann et al (2007). Hemorragias em diferentes locais anatômicos se apresentaram comumente durante a necropsia.…”

Section: Discussionunclassified

“…A idade jovem encontrada na maior parte dos cães também é apresentada em outras publicações, indicando uma maior sensibilidade de jovens em adquirir HIC (Studdert & Studdert 1972, Decaro et al 2007, Inkelmann et al 2007). Entretanto, o acometimento de caninos maiores de um ano também é descrita, podendo ocorrer pela não vacinação ou por um estado imunológico menos eficiente (Greene 2006, Inkelmann et al 2007.…”

Section: Achados Microscópicosunclassified

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Hepatite infecciosa canina em cães naturalmente infectados: achados patológicos e diagnóstico imuno-histoquímico

et al. 2011

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Vinte e três cães com hepatite infecciosa canina (HIC) foram analisados com base nos seus dados gerais, achados clínicos, patológicos e imuno-histoquímicos. As principais lesões macroscópicas encontradas foram palidez do fígado (17/23), hepatomegalia (10/23) e hemorragia (21/23). Observou-se também edema da parede da vesícula biliar (11/23), malhas de fibrina cobrindo a superfície capsular hepática (8/23) e icterícia (6/23). Acentuada necrose hepatocelular foi encontrada associada à identificação de corpúsculos intranucleares anfofílicos e basofílicos em hepatócitos e células endoteliais (22/23) característicos de adenovírus. Identificou-se no baço e linfonodos necrose linfoide, hemorragia e menor ocorrência de corpúsculos intranucleares em células reticuloendoteliais. A imuno-histoquímica (IHQ) foi positiva para adenovírus canino tipo 1 em todos os animais analisados. Os principais órgãos positivos na IHQ foram fígado (23/23), telencéfalo (22/22), cerebelo (16/20) e rim (16/21). Maior marcação de antígenos viral foi observada em hepatócitos e no endotélio vascular do encéfalo e dos tufos glomerulares renais.

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“…Esses achados também foram descritos por Inkelmann et al (2007). Hemorragias em diferentes locais anatômicos se apresentaram comumente durante a necropsia.…”

Section: Discussionunclassified

Section: Achados Microscópicosunclassified

Hepatite infecciosa canina em cães naturalmente infectados: achados patológicos e diagnóstico imuno-histoquímico

et al. 2011

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“…Occasional reports in domestic dogs have been published suggesting a recrudescence of the disease (Decaro et al 2007a). However, surveys conducted in domestic dogs between 1964-2006 in Brazil (Inkelmann et al 2007) detected 2.1% of ICH cases, while in UK 80 cases of ICH were reported in dogs submitted to one centre in the UK from 1986 to 2007 (Thompson et al 2010), providing evidence of ongoing exposure of susceptible dogs to CAdV-1 and suggesting that the occurrence of ICH has probably been underestimated due to underreporting in the last decades. The importance of considering CAdV-1 as a putative aetiological agent when clinical signs are consistent with ICH (Muller et al 2010), as well as persisting with vaccination against CAdV-1/ICH at a worldwide level is necessary in order to increase the immunity of dog populations and to reduce the risk of CAdV-1 transfer from wildlife reservoirs to susceptible dogs.…”

Section: Discussionmentioning

confidence: 99%

Fatal canine adenovirus type 1 acute infection in a Yorkshire Terrier puppy in Portugal: a case report

Duarte¹,

Henriques²,

Lima³

et al. 2014

Vet. Med. - Czech

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This study reports the diagnostic algorithm followed for the identification of a fatal canine adenovirus type 1 (CAdV-1) infection in an unvaccinated 56 day-old puppy to overcome the limitations imposed by inconclusive histopathology hampered by body freezing. The animal was submitted to necropsy after a clinical history of lethargy, dehydration, vomiting and haemorrhagic diarrhoea. Pathological features, suggestive of infectious illness, included generalised gelatinous subcutaneous oedema, petechial, ecchymotic haemorrhages of the subcutaneous tissues and a friable uniformly yellow mottled liver. Differential diagnosis based on PCR ruled out the presence of most common gastrointestinal canine viruses and bacteriology and coprology confirmed that pathogenic bacteria and intestinal parasites did not account for the puppy's death. Strong amplification of CAdV-1 DNA was obtained from liver samples. Isolation of CAdV-1 in MDCK cells was subsequently demonstrated and sequencing analysis showed high similarity with CAdV-1 isolates from Europe. In the absence of serum, antibodies against CAdV-1 were investigated in lung tissue extracts. The presence of CAdV-1 infectious particles and absence of immune response was consistent with rapid progression of the infection and death of the animal two days after the onset of clinical signals, allowing a final diagnosis of the acute form of ICH. Antibodies against CAdV-1 were detected in sera collected from clinically healthy dogs from the same premises, 14-months after the index case, suggesting that the virus had circulated in the breeding kennel. We believe this to be the first report of CAdV-1 in Portugal where canine infectious hepatitis is considered a rare infection.Keywords: canine adenovirus type 1; CAdV-1; infectious canine hepatitis; Mastadenovirus List of abbreviations BID = twice a day, CAdV-1 = canine adenovirus type 1; CAdV-2 = canine adenovírus type 2, CCoV = canine coronavirus; CDV = canine distemper virus, CHV = canine herpesvirus, CPIV = canine parainfluenza virus, CPV = canine parvovirus, CPE = cytopathic effect, ELISA = enzyme linked immunosorbent assay, FCS = foetal calf serum, FITC = fluoresceine isothiocyanate, ICH = infectious canine hepatitis, IgG = immunoglobulin G, IIF = indirect immunofluorescence, LTE = lung tissue extract, MDCK = Madin-Darby canine kidney, PBS = phosphate-buffered saline, PCR = polymerase chain reaction, RV = rotavirus, SID = once a day

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“…Estas doenças são pouco frequentes em cães idosos (Inkelmann et al 2007, Silva et al 2007) e no período estudado nenhum cão idoso apresentou inclusões de HIC ou de cinomose no rim.…”

Section: Discussionunclassified

Lesões do sistema urinário em 1.063 cães

et al. 2012

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Pesq. Vet. Bras. 32(8) The aim of this study was to determine the prevalence, epidemiology, clinical signiϐi-cance, and possible associated causes of the urinary system lesions in dogs necropsied between January 1999 and December 2010 at the Laboratório de Patologia Veterinária of the Universidade Federal de Santa Maria (LPV-UFSM). To accomplish this, the necropsy reports were analyzed retrospectively. In this time frame, 3,189 dogs were necropsied and about 30% had lesions in the urinary system. In most of the dogs (79.1%), lesions were single and in about 21% they were multiple, totalizing 1,373 lesions. Out of them, 1,014 (73.8%) were observed in the kidney and 359 (26.2%) were in the lower urinary tract (LUT). One third of the lesions in the urinary system were causes of spontaneous death or reason for euthanasia (SD/EUTH) of the affected dogs. The other two third of the lesions were considered incidental ϐindings. The main renal lesions diagnosed, in descending order of prevalence, were: tubulointerstitial nephritis, infarct, granulomatous nephritis (parasitary), glomerulonephritis, metastatic/multicentric neoplasms, pyelonephritis/pyelitis, and hydronephrosis. The main LUT lesions, in descending order of prevalence, were: cystitis, presence of viral inclusions bodies (morbillivirus), urolithiasis, urinary bladder dilatation, urinary bladder rupture (with uroperitoneum), and metastatic/multicentric neoplasms. Epidemiological aspects such as gender, breed, and age of affected dogs had expressive variations according to the type of lesion diagnosed. Uremia was observed in a signiϐicant number of cases of SD/EUTH and was mostly due to renal lesions.INDEX TERMS: Lesions of the urinary tract, diseases of dogs, pathology.

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Hepatite infecciosa canina: 62 casos

Cited by 11 publications

References 10 publications

Hepatite infecciosa canina em cães naturalmente infectados: achados patológicos e diagnóstico imuno-histoquímico

Hepatite infecciosa canina em cães naturalmente infectados: achados patológicos e diagnóstico imuno-histoquímico

Fatal canine adenovirus type 1 acute infection in a Yorkshire Terrier puppy in Portugal: a case report

Lesões do sistema urinário em 1.063 cães

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