Uso da ciclofosfamida em modelo de imunodepressão experimental em ovinos

Abstract

Ovine Ovine experimental immunosuppression using cyclophosphamide. experimental immunosuppression using cyclophosphamide. experimental immunosuppression using cyclophosphamide. experimental immunosuppression using cyclophosphamide. experimental immunosuppression using cyclophosphamide.] Uso da ciclofosfamida em modelo experimental de imunodepressão experimental em ovinos. Pesquisa Veterinária Brasileira 24(3): 115-119. Curso de Medicina Veterinária, Universidade Paulista, Rua Enjolras Vampré 146, São Paulo, SP 04290-070, Brazil. E-mail: mgar@mgar.vet.br Cyclophosphamide (CY) was used to evaluate the effect on the immune system of sheep. Castred adult rams were divided into 3 groups, with 6 animals each one. Group I (day 0) and Group II (day 1) were treated with CY (40 mg/kg, single dose, IV), and Group III was not treated and remained as control. All groups were immunized on day 0 with B19 brucellosis vaccine. On day 6, all animals were bled and serum agglutination test for brucellosis antibodies detection was performed. During 7 days blood lymphocyte counts and electrophoresis gammaglobulin dosage were daily performed. The results showed statistical decrease of immune response. Low serum titers of brucellosis antibodies were found in Groups I and II, and lymphopenia and hypogammaglobulinemia were also found in these groups. A high mortality rate (40%) occurred in the treated animals.

Adjuvant effect of LPS and killedPropionibacterium acneson the development of experimental gastrointestinal nematode infestation in sheep

“…The immune response role in helminthiasis was also demonstrated by Garcia et al. (12), that demonstrated more severe helminthiasis development when previously induced immunossupression in sheep using cyclophosphamide.…”

“…There was also demonstrated that T lymphocytes from T. colbriforms infected sheep (46) and Ostertagia ostertagi infected cattle (47) showed in vitro decrease of the proliferative response to mitogen. Severe helminthiasis was also observed when sheep was submitted to immunosuppression by cyclophosphamide treatment (12).…”

Effect of ultra-diluted nux vomica and cyclophosphamide solutions on the genotoxicity of allopathic cyclophosphamid

“…However, in the global blood count, it was observed that the groups not treated and treated with vehicle had WBC values significantly higher than the CF group. This is in line with what was described by Garcia et al (2004), who stated that this effect is due to CF, which is a potent immunosuppressant that acts on cells with high mitotic activity, inhibiting the humoral and cellular immune response. Despite treating malignant and non-malignant diseases (Hosseinimehr & Karami, 2005), the side effectsmost commonly observed with CF use refers to the effect on the hematopoietic tissue, causing myelodepression (leukopenia, thrombocytopenia, anemia) (Schuurman et al, 2005), a fact confirmed by the World Health Organization (WHO), which points it out as the most commonly reported adverse reactions in patients undergoing chemotherapy.…”

Extrato De Echinodorus Grandiflorus Apresenta Efeito Renoprotetor Em Ratos Com Nefrotoxicidade Aguda Induzida Pela Ciclofosfamida

“…A leucopenia encontrada no presente estudo, foi também descrita por Garcia et al (2004) em ovinos no modelo de imunossupressão experimental. Segundo demonstrado por Hellman e Grate (1976) a ciclofosfamida mata grande parte das células precursoras na medula, além de diminuir o potencial eritropoiético das células restantes.…”