Intoxicação por Ateleia glazioviana (Leg. Papilionoideae) em bovinos

Abstract

A disease affecting cattle from western Santa Catarina and northwestern Rio Grande do Sul, characterized by nervous and caradiovascular manifestations, is described. The animals succumbed by "sudden death" or showed subcutaneous pendant edema and engorged pulsating jugular veins, preceded or not by apathy, lethargy and blindness. The disease affects cattle over 1 year of age and occurs mainly during fall and winter. Morbidity rates are 10-60% and mortality may be up to 95%. Gross lesions include pale and firm areas in the myocardium, mainly along the coronary vessels and extending into the septum. In part of the animals, the liver is enlarged and has a nutmeg appearance. Histopathological changes include swelling and necrosis of cardiac myofibers, and interstitial fibrosis and macrophagic infiltrate in the cardiac muscle, as well as severe centrolobular congestion and slight fibrosis in the liver. In the white matter of the brain of animals that showed clinical signs of lethargy, spongy degeneration (status spongiosus) is seen. The disease with lethargic manifestations was reproduced experimentally in cattle by feeding the leaves of Ateleia glaziovana in single doses of 40 and 50 g/kg and subdivided daily doses of 2.5, 5.0, 7.5 and 10 g/kg over long periods, with the initial dose of 1g/kg, additioned by 1g/kg/day till reaching 15g/kg, totaling 120 g/kg.INDEX TERMS: Poisonous plants, Ateleia glaziovana, degenerative cardiopathy, "sudden death", brain edema (status spongiosus), cattle, pathology.

Chronic cardiomyopathy and encephalic spongy changes in sheep experimentally fed Ateleia glazioviana

“…Pathological lesions consisted of chronic degenerative cardiomyopathy and spongy degeneration of the white matter of the brain. These lesions are remarkably similar to those found in cattle (GAVA & BARROS, 2001) and sheep (GAVA et al, 2003) with naturally occurring intoxication with A. glazioviana.…”

“…These included depression, loss of appetite, weakness, staggering gait and prolonged periods of recumbency. Similar signs have been described in spontaneous and experimental poisoning by A. glazioviana in cattle (GAVA & BARROS, 2001) and in sheep (STIGGER et al, 2001;GAVA et al, 2003) and have been atributted to spongy degeneration (status spongiosus) of the white matter of the brain and it has been suggested that this lesion is potentially reversible (GAVA & BARROS, 2001). Histological lesions of spongy degeneration were observed in the brains of 10 of 15 sheep fed A. glazioviana.…”

“…The spontaneous intoxication by A. glazioviana has now been reported in sheep (GAVA et al, 2003) and the pathogenesis of abortion and other forms of reproductive failure associated with the ingestion of A. glazioviana in sheep were recently determined (RAFFI et al, 2004).…”

Fibrose cardíaca associada à intoxicação por Amorimia septentrionalis em bovinos

“…e Ateleia glazio- viana (Gava et al 2001, Peixoto et al 1995, Tokarnia et al 1989. Porém essas plantas não ocorrem na região estudada.…”

Pathological aspects of experimental poisoning of goats by Stryphnodendron fissuratum pods (Fabaceae)

“…The brainstem spongiosis described in this work can be ascribed to the direct action of S. fissuratum toxic principles (Haraguchi et al 2006;Yokosuka et al 2008), given that triterpene saponins can open calcium and potassium dependent channels in neuron cell membranes (McManus et al 1993), with a consequent cytotoxic oedema (McGavin and Zachary 2007). Central nervous system spongiosis also occurs in poisonings by plants such as Tetrapterys multiglandulosa in bovines and goats (Tokarnia et al 2000;Riet-Correa et al 2005), Ateleia glazioviana in bovines and sheep (Gava et al 2001;Raffi et al 2006), Helichrysum argyrosphaerum in sheep and goats (Van der Lugt et al 1996), beside Ornithogalum saundersiae and O. prasinum in bovines (Van der Lugt 2002). In these intoxications, electronic microscopic studies have shown that the lesion is a consequence of intramyelinic oedema of the white substance (Van der Lugt 2002;Riet-Correa et al 2005;Raffi et al 2006).…”