Síndrome hiperandrogênica em mulher na pós-menopausa: relato de caso

Abstract

Hyperandrogenic syndromes include diseases that manifest through an increased biological activity of androgens and that can originate from neoplastic or functional diseases. Androgen-secreting ovarian tumors represent about 1% of ovarian neoplasias. Steroid cell tumors are among the more rare types which account for less than 0.1% of all ovarian tumors. They are usually benign, of small dimensions and unilateral. We report here a rare case of a unilateral steroid cell tumor. A 60-year-old woman was seen after four months of evolution of hirsutism, clitoris hypertrophy and elevation of serum estradiol levels. Her total testosterone and 17-OH-progesterone levels were also increased.

Ovarian Hemangioma With Stromal Luteinization

“…Hyperandrogenism is associated with an increased incidence of dyslipidemia, insulin resistance, arterial hypertension, and cardiovascular disease, with significant implications for the psychological well-being of the patient [1,5,7]. However, there is not always a correlation between the levels of androgens and the intensity of clinical manifestations [7].…”

“…The reappearance of vasomotor disorders after surgery seems to mimic what happens when menopause begins, which is explained by the resolution of hyperandrogenism and consequently the drop in estrogens by the aromatization process. The definitive diagnosis is given by histopathological evaluation and immunohistochemical analysis [7,8]. A correct diagnosis is essential to avoid radical surgical procedures and…”