Dosagem de folatos maternos e fetais, séricos e eritrocitários em malformações por defeito de fechamento do tubo neural no feto

Bunduki, Victor; Martinelli, Silvio; Cabar, Fábio Roberto; Miyadahira, Seizo; Dommergues, Marc; Zugaib, Marcelo

doi:10.1590/s0100-72031998000600006

Cited by 3 publications

(3 citation statements)

References 17 publications

(26 reference statements)

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“…39 Regarding FA, some works have demonstrated that its deficiency during pregnancy changes cell division, which is more meaning in tissues with a high proliferation rate. 40 Cell multiplications, as well as rapid growth, which are central aspects of fetal development require a suitable folate supply. Meher et al 41 found reduction of liver absolute weight in offspring from dams fed on low quantities of it during gestation and lactation, besides changed hepatic transcription factors expression.…”

Section: Fetal Programmingmentioning

confidence: 99%

Impact of Maternal Folic Acid Supplementation on Descendants' Kidney in Adulthood

Fernandes

Conde

Brasil

et al. 2023

Rev Bras Ginecol Obstet

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Supplementation with folic acid (FA) during gestation has been recommended by medical society all over the world, but some studies have shown that intake of high folic acid diet may unleash damages to the descendants. Objectives: Describing the effects of maternal supplementation with FA during gestation on offspring's kidney at late life stages. Data Source: It is a systematic review by which were consulted the following databases: Medline, through Pubmed, Lilacs, and SciELO. The research was performed using the keywords “Folic acid”, “Gestation” and “Kidney”. Study Selection: Eight studies were regarded for this systematic review. Data Collection: Only studies that evaluated folic acid consumption during gestation and its effects exclusively on descendants' kidney at several phases of life were regarded. Results: Gestational FA intake did not change the renal volume, glomerular filtration rate and the expression of some essential genes in the kidney of puppies whose dams were supplemented with FA. Maternal consumption of double FA plus selenium diet was effective in preserving antioxidant enzymes activity in the kidney of descendants from mothers exposed to alcohol. FA supplementation decreased some gross anomalies in the puppies caused by teratogenic drug despite of had not been effective in preventing some renal architectural damages. Conclusion: FA supplementation did not cause renal toxicity; it exerted an antioxidant protective effect and mitigated some renal disorders caused by severe aggressions.

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Section: Fetal Programmingmentioning

confidence: 99%

Impact of Maternal Folic Acid Supplementation on Descendants' Kidney in Adulthood

Fernandes

Conde

Brasil

et al. 2023

Rev Bras Ginecol Obstet

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“…Low dietary intake of this vitamin may compromise the mother's and child's health, making them more susceptible to preeclampsia, megaloblastic anemia, low birth weight, preterm birth, chromosomal changes, and fetal malformations due to Neural Tube Defects (NTD) [1][2][3][4] .…”

Section: Introductionmentioning

confidence: 99%

Folate inadequacy in the diet of pregnant women

2014

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OBJECTIVE: To estimate food and dietary folate inadequacies in the diets of adult pregnant women. METHODS: A prospective study was conducted with 103 healthy pregnant adult users of the Public Health Care System of Ribeirão Preto, São Paulo, Brazil. The present study included the 82 women with complete food intake data during pregnancy, which were collected by three 24-hour dietary recalls. Food folate (folate naturally present in foods) and dietary folate (food folate plus folate from fortified wheat flour and cornmeal) inadequacies were determined, using the Estimated Average Requirement as cutoff. RESULTS: The diets of 100% and 94% of the pregnant women were inadequate in food folate and dietary folate, respectively. However, fortified foods increased the medium availability of the nutrient by 87%. CONCLUSION: The large number of pregnant women consuming low-folate diets was alarming. Nationwide population studies are needed to confirm the hypothesized high prevalence of low-folate diets among pregnant women.

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“…Um estudo de revisão sobre os micronutrientes na gestação identificou que a deficiência de ferro resulta em anemia materna; a deficiência de zinco tem sido associada com complicações na gravidez e com anomalias congênitas; e a deficiência de iodo pode ocasionar perda fetal e parto prematuro (BLACK, 2001). SCHOOL et al, 1996;MOLLY et al, 2009;BUNDUKI et al;1998 A primeira indicação da suplementação com ácido fólico foi para a prevenção e tratamento da anemia megaloblástica e anemia materna (WHO, 1968;SMAIL, 1981). No…”

Section: Introductionunclassified

Estimativa de folato na dieta de gestantes: o papel da fortificação de farinhas e do suplemento dietético

Crivellenti¹

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À minha orientadora Prof a Dr a Daniela Saes Sartorelli, pela sabedoria em ensinar, confiança, apoio, dedicação e imensa contribuição na minha formação profissional. Aos funcionários da Secretaria de Pós-Graduação do Departamento de Medicina Social da FMRP-USP, Paula Maria Pereira e Sérgio Carlos Nascimento, por estarem sempre dispostos a nos ajudar. Aos membros titulares da banca de mestrado, Prof. Dr. Eliseu Verly Junior e Prof a Dr a Fabiana Vilela Mamede, pelas sugestões à dissertação, que muito contribuíram para o meu aprendizado. Aos meus pais, Renato e Adriana, que sempre apoiaram e respeitaram as minhas escolhas, pelas oportunidades proporcionadas, amor, amizade e paciência. Ao meu irmão, Rafael, pelo companheirismo, carinho e por sempre incentivar minhas decisões pessoais e profissionais. Ao meu namorado Rodolpho, por acreditar nas minhas realizações, pelo carinho, paciência, pelos momentos de reflexão e por estar sempre presente na minha vida. Às amigas: Daniela, Patrícia e Renata, pela parceria, companheirismo nos trabalhos, pelos momentos de descontração e pelas boas risadas. Às minhas avós Aparecida e Maria, pelas orações, gestos de carinho e por torcerem pela minha carreira profissional.

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Dosagem de folatos maternos e fetais, séricos e eritrocitários em malformações por defeito de fechamento do tubo neural no feto

Cited by 3 publications

References 17 publications

Impact of Maternal Folic Acid Supplementation on Descendants' Kidney in Adulthood

Impact of Maternal Folic Acid Supplementation on Descendants' Kidney in Adulthood

Folate inadequacy in the diet of pregnant women

Estimativa de folato na dieta de gestantes: o papel da fortificação de farinhas e do suplemento dietético

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