Local control of human papillomavirus infection after anal condylomata acuminata eradication

Manzione, Thiago da Silveira; Nadal, Sidney Roberto; Calore, Edenilson Eduardo; Nadal, Luís Roberto Manzione; Manzione, Carmen Ruth

doi:10.1590/s0100-69912014000200003

Cited by 6 publications

(8 citation statements)

References 28 publications

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“…Based on the result of these studies, it is noted that the histopathology may be a very important tool in the diagnostic of cases of viral injuries by HPV even before their clinical manifestation, from a careful assessment in optic microscopy of surgical pieces and tissues fragments removed from the anal region 5 , 7 , 8 , 9 , 10 , 11 .…”

Section: Discussionmentioning

confidence: 99%

“…The main goal of this paper was to draw attention to the quantity of subclinical cases of HPV, that may no longer be early diagnosed due to the simple lack of more specialized histopathology that differentiates other anal injuries 5 , 7 , 8 . Attesting the casual relation between HPV and hemorrhoids was not the aim of this study.…”

Section: Discussionmentioning

confidence: 99%

“…The anal HPV predominates in some groups, such as in patients carrying idiopathic anal itching, with antecedents of clinical form of anal HPV treatment, with antecedents of genital HPV treatment, who look for the ambulatories of sexually transmitted diseases, HIV positives, prostitutes and with risky behavior for sexually transmitted diseases. However, this disease also affects people who do not belong to these groups, and may be acquired by other forms beyond the sexual relationship 2 , 6 , 7 , 8 , 10 .…”

Section: Introductionmentioning

confidence: 99%

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Association Among Histological Findings Suggestive of Papilloma Virus on Hemorrhoidectomy Specimens

Silva

Nakajima

Guimarães

et al. 2015

ABCD, arq. bras. cir. dig.

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Background:Many researchers studied human Papillomavirus infection in the anal area supposing it represents a risk factor for precursor lesions of anal cancer.Aim: To study the association between histological findings suggestive of injury by the virus in hemorrhoidectomy specimens. Method: Prevalence study was carried out based on histopathological analysis of hemorrhoidectomy specimens to find viral cytopathic effects. These findings were compared with anal condyloma acuminata that had no relationship with hemorrhoidectomy for microscopic comparison. Results: Of the 91 hemorroidectomies analyzed, eight had findings suggestive of viral cytopathic effects, with the presence of irregular acanthosis in 63%, koilocytes in 50% and other indirect viral cytopathic effects, such as hyperkeratosis (38%), parakeratosis (25% ) and papillomatosis (13%). Conclusion: This study was unable to conclude that there is an association between these two pathologic entities.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Association Among Histological Findings Suggestive of Papilloma Virus on Hemorrhoidectomy Specimens

Silva

Nakajima

Guimarães

et al. 2015

ABCD, arq. bras. cir. dig.

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“…Treatment methods for CA are potentially expensive, time-consuming and not without complications. Recurrence rates are up to 88%, depending on the used therapeutic method 2,3 . HPV 6 and 11 are low-risk types associated to most of the CA cases, and they are linked to coinfection with other HPV types in about 50% of the lesions 4 , including high-risk types associated to anogenital SCC [4][5][6] .…”

Section: Introductionmentioning

confidence: 99%

Comparison between anal cytology, high-resolution anoscopy and HPV DNA genotyping by polymerase chain reaction in the post-treatment follow-up of condylomata acuminata

Nadal

Saad

Filho

et al. 2020

Rev. Col. Bras. Cir.

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Aim: to evaluate the presence of subclinical HPV-induced anal lesions with anal cytology, High-Resolution Anoscopy (HRA) and HPV genotyping by polymerase chain reaction (PCR) in the follow-up of treated condylomata acuminata (CA). Methods: seventy-nine male patients were included. One month after anal CA eradication, the patients underwent brush samples collection for anal cytology and PCR, and HRA with biopsy of acetowhite lesions. These methods were compared within all patients and between groups, according to Human Immunodeficiency Virus (HIV) infection status: HIV-negative; HIV-positive with TCD4 count above and below 350 cells/mm3. Results: the most frequent HPV types were 6 and 16. HPV DNA was isolated in 92%. HIV infection was associated with a higher number of oncogenic HPV types (p=0.038). All patients with negative PCR had negative HRA and cytology. There were no differences in cytological, HRA or histopathological findings between groups. Conclusion: the association of the findings of cytopathology, HRA and genotyping of HPV refined the diagnosis of HPV-induced lesions. The degree of immunodeficiency was not associated with increase in remnant HPV-induced anal lesions.

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“…Moreover, there is no consensus on the best treatment to manage these lesions. In clinical practice, there are various treatment modalities including physical ablation [electrosurgery excision, cryotherapy, infrared coagulation (IRC), laser ablation], and pharmacological treatments (imiquimod, podophyllotoxin, tricloracetic acid, sinecatechins) [ 7 – 9 ]. Generally, the election of the treatment depends on localization, size, number of the CAs and on the doctor’s experience.…”

Section: Introductionmentioning

confidence: 99%

Effectiveness of physically ablative and pharmacological treatments for anal condyloma in HIV-infected men

et al. 2018

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BackgroundThere is limited information on the effectiveness of available treatments for anal condyloma acuminata in HIV-1-infected men.AimTo provide data on the effectiveness of electrosurgical excision, infrared coagulation and pharmacological (imiquimod) treatments for anal condyloma acuminata (peri-anal and/or intra-anal) in HIV-1-infected men based on authors’ practice.MethodsSingle-center, retrospective descriptive analysis of HIV-1-infected men, 18 years or older treated for anal condyloma acuminata. Standard treatments were offered: electrosurgery excision, infrared coagulation and topical imiquimod. Effectiveness was evaluated by the recurrence rate at 1 year after treatment. Recurrence was defined as any anal condyloma acuminata diagnosed after 3 months of condyloma-free survival post-treatment. Anal cytology and human-papillomavirus-infection (HPV) was assessed.ResultsBetween January 2005 and May 2009, 101 men were treated for anal condyloma acuminata: 65 (64%) with electrosurgery, 27 (27%) with infrared coagulation and 9 (9%) with imiquimod. At 1 year after treatment, the cumulative recurrence rate was 8% (4/65, 95%CI: 2–15%) with electrosurgery excision, 11% (3/27, 95%CI: 4–28%) with infrared coagulation and 11% (1/9, 95%CI: 2–44%) with imiquimod treatment. No predictive factors were associated with recurrence.Anal HPV-6 or HPV-11 was detectable in 98 (97%) patients and all had high-risk HPV genotypes, and 89 (88%) patients had abnormal anal canal cytology. Limitations: this was a retrospective descriptive analysis; limited to a single center; it cannot know if the recurrence is related to new infection.ConclusionRecurrence of anal condyloma after any treatment was common. Abnormal anal cytology and high-risk HPV-infection were highly prevalent in this population, therefore at high-risk of anal cancer, and warrants careful follow-up.

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Local control of human papillomavirus infection after anal condylomata acuminata eradication

Abstract: the eradication of clinical lesions failed to locally control HPV infection.

Cited by 6 publications

References 28 publications

Association Among Histological Findings Suggestive of Papilloma Virus on Hemorrhoidectomy Specimens

Association Among Histological Findings Suggestive of Papilloma Virus on Hemorrhoidectomy Specimens

Comparison between anal cytology, high-resolution anoscopy and HPV DNA genotyping by polymerase chain reaction in the post-treatment follow-up of condylomata acuminata

Effectiveness of physically ablative and pharmacological treatments for anal condyloma in HIV-infected men

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